Title:Nanotechnological Advances in the Diagnosis of Gynecological Cancers and Nanotheranostics
Volume: 30
Issue: 33
Author(s): Vahideh Keyvani, Samaneh Mollazadeh, Espanta Riahi, Reihaneh Alsadat Mahmoudian, Kazem Anvari and Amir Avan*
Affiliation:
- Metabolic Syndrome Research
Center, Mashhad University of Medical Sciences, Mashhad, Iran
- Faculty of Health, School of
Biomedical Sciences, Queensland University of Technology (QUT), Brisbane 4059, Australia
Keywords:
NP-based diagnostics, gynecological cancer diagnosis, ovarian cancer, cervical cancer, nanotechnological platforms, cancer cells.
Abstract: Gynecological cancers are one of the main causes of female mortality worldwide. Despite the various
strategies to reduce mortality and improve quality of life, there are still many deficiencies in the diagnosis
and treatment of gynecological cancers. One of the important steps to ensure optimal cancer treatment is the
early detection of cancer cells and the use of drugs to reduce toxicity. Due to the increase in systemic toxicity
and resistance to traditional and conventional diagnostic methods, new strategies, including nanotechnology,
are being used to improve diagnosis and reduce the severity of the disease. Nanoparticles (NPs) provide exciting
opportunities to improve Gynecological Cancers (GCs) diagnosis, particularly in the initial stages. In
biomedical investigations and clinical settings, NPs can be used to increase the sensitivity and specificity of
recognition and/or imaging of GCs with the help of their molecular and cellular processes. To design more efficient
diagnostic NPs for gynecological cancer cells or tissues, determining the specific biomarkers is of great
importance. NP-based imaging agents are another solution to trace cancer cells. This review highlights the potential
of some NP-based diagnostic techniques in GC detection, which could be translated to clinical settings
to improve patient care.
