Title:Thermo-Gravimetric Studies and Specific Heat Capacity Estimations of the Products of Biginelli Reaction using TGA-DSC
Volume: 14
Issue: 3
Author(s): K.C. Sawant, C.H. Sarode, Y.V. Marathe, G.R. Gupta*S.A. Dhanmane*
Affiliation:
- Department of Chemistry, G.T.P. Arts, Commerce and Science College, Nandurbar, 425412, India
- Department of Chemistry, Fergusson College (autonomous), Pune, 411004, India
Keywords:
Pyrimidone, thermal analysis, specific heat capacity, organic chemistry, Biginelli reaction, heterocycles.
Abstract:
Aims: In this work, the thermal behavior and specific heat capacities of nine
derivatives which were obtained via Biginellipyrimidone synthesis reaction have been
experimentally determined using thermal gravimetry analysis and differential scanning
calorimetry, and the obtained results have been thoroughly analyzed and discussed. The
influence of the structural variation on the thermal analysis has been discussed along with
the influence of the structure of the derivatives of pyrimidines on the specific heat capacity.
Background: To date, heterocycles have successfully been switched from synthetic organic
chemistry laboratory to the core of a variety of biomolecules, conducting devices
and so on. Derivatives of 2-hydroxypyrimidine or pyrimidines have a wide window of
pharmaceutical applications. Therefore, attempts have been made to understand the
thermal response of these organic frameworks.
Objectives: The main objective of this study was to explore thermal methods to understand
heat-induced structural interactions as well as the specific heat capacity (Cp) as a
function of temperature for the synthesized derivatives of 2-hydroxy pyrimidine or pyrimidones.
Methods: Room temperature condensation of ethyl acetoacetate, urea, and variety of aldehydes
or ketones has been optimized in ionic liquids for the formation of pyrimidones.
Thereafter, the thermal profiles of the synthesized derivatives of pyrimidines have been
studied thoroughly and the thermal response of the synthesized derivatives of pyrimidones
gives sound information about thermal stability of these heterocycles.
Results: In the present work, the effect of substituents on the thermal behavior of the
synthesized derivatives of pyrimidines has been investigated with the help of TGA-DSC
analysis. Specific heat capacity (Cp) data as a function of temperature for the synthesized
derivatives of pyrimidones have been reported for the first time.
Conclusion: The specific heat capacity data of the molecules of high commercial and biological
relevance such as pyrimidines like organic frameworks play a subtle role in the
development of the computational methods and molecular modelling, to comprehend the
fundamentals of these molecular frameworks and effectively explore the pharmaceutical
as well as materialistic potentials of these heterocyclic frameworks via simulation.
