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Research Article

A Kinetic and Mechanistic Study of Ir (III)-Catalyzed Oxidation of Methionine by HCF (III) in an Aqueous Alkaline Medium

Author(s): Savita Garg* and Shakunj Rajput

Volume 14, Issue 3, 2024

Published on: 27 May, 2024

Page: [194 - 204] Pages: 11

DOI: 10.2174/0118779468300293240506112752

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Abstract

Introduction: The kinetic study of Ir (III) chloride-catalyzed oxidation of methionine by hexacyanoferrate (abbreviated as HCF) III ions in aqueous alkaline medium was performed spectrophotometrically at constant ionic strength of 0.5 moldm-3 and temperature of 35±0.1°C.

Methods: The progress of the reaction was found to be first-order rate dependence kinetics with respect to [HCF (III)], [OH-], and [IrCl3]. The rate of reaction was found to decrease with an increased concentration of methionine. The ionic strength of the reaction mixture showed a positive salt effect on the reaction rate. Different activation parameters were also evaluated by studying the reaction at four different temperatures. The stoichiometry of the reaction showed Methionine: HCF (III) = 1:4.

Result: The oxidation product of the reaction was found to be methionine sulphone, which was identified by an organic solvent method and IR Spectroscopy. Further, a suitable mechanism was proposed to explain all the experimental results.

Conclusion: It is assumed that the reaction proceeded through complex formation between substrate (oxidant) and iridium trichloride. A rate law was derived, which verified the results.

CH3-S-(CH2)2-CH (NH2)-COO- + 4HCF (III) Ir (III), H2O→ CH3-SO2-(CH2)2-CH-(NH2)-COO- + 4HCF (II)

Keywords: Iridium (III), hexacyanoferrate (III), methionine, oxidation, kinetics, mechanism.

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Graphical Abstract

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