Title:Comprehensive Overview of Innovative Strategies in Preventing Renal
Ischemia-reperfusion Injury: Insights from Bibliometric and In silico Analyses
Volume: 30
Issue: 20
Author(s): Myltykbay S. Rysmakhanov*, Afshin Zare, Aibolat S. Smagulov, Nurgul A. Abenova, Nadiar M. Mussin, Yerlan B. Sultangereyev, Bazylbek S. Zhakiyev, Gani K. Kuttymuratov, Mehmet Haberal, Nazanin Jafari, Hanieh Baneshi, Shabnam Bakhshalizadeh, Mahdi Mahdipour, Farhad Rahmanifar and Amin Tamadon
Affiliation:
- Department of Surgery and Urology No. 2, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
- Department
of Surgery and Transplantation, Aktobe Medical Center, Aktobe, Kazakhstan
Keywords:
Ischemia-reperfusion injury, molecular docking, bibliometric analysis, kidney reperfusion, kidney transplantation, renal resection.
Abstract:
Background: Ischemia-reperfusion Injury (IRI) is a complex pathophysiological process with severe
consequences, including irreversible loss of renal function. Various intraoperative prevention methods
have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion.
Aim: This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods
for preventing and treating renal IRI.
Methods: Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including
Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor
(MR), and Toll-like Receptor 4 (TLR4). This finding indicates eplerenone's potential as a potent preventive
agent against IRI, surpassing other available therapeutics like Benzodioxole, Hydrocortisone, Indoles, Nicotinamide
adenine dinucleotide, and Niacinamide. In preventing kidney IRI, our comprehensive analysis emphasizes
the significance of eplerenone due to its strong binding affinity to key targets involved in the pathogenesis
of IRI.
Results: This finding positions eplerenone as a promising candidate for further clinical investigation and consideration
for future clinical practice.
Conclusion: The insights provided in this analysis will assist clinicians and researchers in selecting effective
preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.