Title:Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells
Volume: 25
Issue: 2
Author(s): Fatemeh Jalali-Zefrei, Seyed Mehdi Mousavi, Kourosh Delpasand, Mohammad Shourmij and Soghra Farzipour*
Affiliation:
- Department of Cardiology, Cardiovascular Diseases Research Center, Heshmat Hospital, School of Medicine, Guilan
University of Medical Sciences, Rasht, Iran
- Department of Pharmaceutical Biotechnology, School of Pharmacy, Guilan University of
Medical Sciences, Rasht, Iran
Keywords:
Non-coding RNA, radioresistance, radiosensivity, radiotherapy, cancer, longer ncRNA, miRNA.
Abstract: Radiotherapy (RT) is an integral part of treatment management in cancer patients. However,
one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy.
These restrictions necessitate the introduction of modalities for the radiosensitization of cancer
cells. It has been shown that Noncoding RNAs (ncRNAs), along with modifiers, can act as radiosensitivity
and radioresistant regulators in a variety of cancers by affecting double strand break
(DSB), wnt signaling, glycolysis, irradiation induced apoptosis, ferroptosis and cell autophagy.
This review will provide an overview of the latest research on the roles and regulatory mechanisms
of ncRNA after RT in in vitro and preclinical researches.