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Current Gene Therapy

Editor-in-Chief

ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Review Article

Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells

Author(s): Fatemeh Jalali-Zefrei, Seyed Mehdi Mousavi, Kourosh Delpasand, Mohammad Shourmij and Soghra Farzipour*

Volume 25, Issue 2, 2025

Published on: 26 April, 2024

Page: [113 - 135] Pages: 23

DOI: 10.2174/0115665232301727240422092311

Price: $65

Open Access Journals Promotions 2
Abstract

Radiotherapy (RT) is an integral part of treatment management in cancer patients. However, one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy. These restrictions necessitate the introduction of modalities for the radiosensitization of cancer cells. It has been shown that Noncoding RNAs (ncRNAs), along with modifiers, can act as radiosensitivity and radioresistant regulators in a variety of cancers by affecting double strand break (DSB), wnt signaling, glycolysis, irradiation induced apoptosis, ferroptosis and cell autophagy. This review will provide an overview of the latest research on the roles and regulatory mechanisms of ncRNA after RT in in vitro and preclinical researches.

Keywords: Non-coding RNA, radioresistance, radiosensivity, radiotherapy, cancer, longer ncRNA, miRNA.

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