Title:Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic
Insights
Volume: 30
Issue: 18
Author(s): Atena Soleimani, Nikoo Saeedi, Abdulridha Mohammed Al-Asady, Elnaz Nazari, Reyhane Hanaie, Majid Khazaei, Elnaz Ghorbani, Hamed Akbarzade, Mikhail Ryzhikov, Amir Avan and Seyed Mahdi Hasanian Mehr*
Affiliation:
- Department of Biochemistry, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran
Keywords:
LGR5, ALDH, CD166, CD133, CD44, cancer stem cell, colon cancer.
Abstract: Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells
(CSCs) increase the probability of tumor development. These cells are identified by using CSC markers,
which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs
as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present
review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133,
and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these
markers cancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and
clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate
understanding and stimulate further research for developing effective diagnostic and therapeutic strategies
in CRC.