Title:Cerebral Small Vessel Disease Burden in Patients with Transient Global Amnesia and its Relationship with Recurrence
Volume: 21
Issue: 3
Author(s): Zhi-li Wang, Simeng Wang, Dongtao Liu, Yuelei Lyu, Wei Qin*Wenli Hu*
Affiliation:
- Department of Neurology, Beijing ChaoYang Hospital, Capital Medical University, Beijing, China
- Department of Neurology, Beijing ChaoYang Hospital, Capital Medical University, Beijing, China
Keywords:
Transient global amnesia, cerebral small vessel disease, enlarged perivascular spaces, hippocampus, TGA recurrence, H-EPVS.
Abstract:
Objective: Cerebral Small Vessel Disease (CSVD) has not been systematically studied
in patients with Transient Global Amnesia (TGA). We aimed to investigate the CSVD burden
in patients with TGA and its relationship with TGA recurrence.
Methods: We retrospectively examined 69 patients diagnosed with TGA in a single center between
January 2015 and November 2023. The overall CSVD burden and single CSVD imaging
markers, including enlarged perivascular spaces in the hippocampus (H-EPVS), were measured
in each patient and compared with those in 69 age- and sex-matched healthy controls. Multivariate
logistic regression was performed to determine independent predictors of recurrence.
Results: Of the 69 included patients, 40 (58%) were female, and the median age was 67 years
(range 42-83 years). Twenty-one patients (30.4%) showed dot-like hippocampal hyperintensities
on diffusion-weighted imaging (DWI). The mean follow-up was 51 months. Sixteen patients
(23.2%) experienced TGA recurrence. The burden of overall CSVD, lacunes, WMH, EPVS, and
extensive H-EPVS was higher in TGA patients than in controls. TGA patients who experienced
recurrence had a heavier overall CSVD burden, lower frequency of hippocampal DWI hyperintensities,
and longer follow-up duration than those who had with single episode. In the multivariate
analysis, only follow-up duration was an independent predictor of TGA recurrence.
Conclusion: The overall CSVD burden and extensive H-EPVS burden were higher in patients
with TGA than healthy controls. Follow-up duration but not overall CSVD burden may predict
TGA recurrence.
