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Review Article

Genetic Factors and MicroRNAs in the Development of Gallbladder Cancer: The Prospective Clinical Targets

Author(s): Roshni Quraishi, Somali Sanyal, Medha Dwivedi, Monika Moitra and Manish Dwivedi*

Volume 25, Issue 6, 2024

Published on: 27 March, 2024

Page: [375 - 387] Pages: 13

DOI: 10.2174/0113894501182288240319074330

Price: $65

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Abstract

Gallbladder cancer (GBC) is an uncommon condition in which malignant (cancer) cells are detected in gallbladder tissue. Cancer is often triggered when normal cells turn malignant and begin to spread. Cancer can also be caused by genetic anomalies that result in uncontrolled cell proliferation and tumor development. MicroRNAs (also known as miRNAs or miRs) are a group of small, endogenous, non-coding RNAs of 19-23 nucleotides in length, which play a key role in post-transcriptional gene regulation. These miRNAs serve as negative gene regulators by supervising target genes and regulating biological processes, including cell proliferation, migration, invasion, and apoptosis. Cancer development and progression relate to aberrant miRNA expression. This review demonstrated the implication of various genetic factors and microRNAs in developing and regulating GBC. This suggests the potential of genes and RNAs as the diagnostic, prognostic, and therapeutic targets in gallbladder cancer.

Keywords: Gallbladder cancer, epidemiology, risk factors, microRNA, RNAs, genetic factors.

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