Title:A New Approach in the Early Electrochemical Diagnosis of Hepatitis B
Virus Infection using Carbon-based Nanomaterials
Volume: 19
Issue: 2
Author(s): Navid Omidifar, Reza Masoumzadeh, Seyyed Amirreza Saghi, Ali Nikmanesh, Mansoureh Shokripour, Seyyed Mojtaba Mousavi, Yousef Nikmanesh*Ahmad Gholami*
Affiliation:
- Gastroenterohepatology Research Center, Shiraz
University of Medical Sciences, Shiraz, Iran
- Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
- Department of Pharmaceutical Biotechnology, School of Pharmacy,
Shiraz University of Medical Sciences, Shiraz, Iran
Keywords:
Viral hepatitis, graphene, carbon nanotubes, quantum dot, early diagnosis, Electrochemical immunosensors.
Abstract: The importance of early diagnosis of hepatitis B virus infection to treat and follow up this
disease has led to many advances in diagnostic techniques and materials. Conventional diagnostic
tests are not very useful, especially in the early stages of infection; it is therefore suggested that nanomaterials
can enhance them by changing and strengthening their performance for a more accurate
and rapid diagnosis. Electrochemical immunosensors with unique features such as miniaturization,
low cost, specificity and simplicity have become a suitable and vital tool in the rapid diagnosis of
hepatitis B since the patent. Different strategies have been presented, such as graphene oxide and
gold nanorods (GO-GNRs), graphene oxide (GO), copper metal–organic framework/ electrochemically
reduced graphene oxide (Cu-MOF/ErGO) composite, Label-free graphene oxide/
Fe3O4/Prussian Blue (GO/Fe3O4/PB) immunosensor, and graphene oxide–ferrocene-CS/Au (GOFc-
CS/Au) nanoparticle layered electrochemical immunosensor. In this review, we discuss a group
of the most widely used nanostructures, such as graphene and carbon nanotubes, which are used to
develop electrochemical immunosensors for the early diagnosis of the hepatitis B virus.
