Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Research Article

Effect of Liver Segments and Hepatic Fibrosis Grade on Repeatability, Reliability, and Diagnostic Efficiency of Intravoxel Incoherent Motion

Author(s): Lesheng Huang, Jun Chen, Weiyin Vivian Liu, Guangjun Tian, Qian Wei, Hui Peng, Wanchun Zhang, Hongyi Li, Se Peng and Tianzhu Liu*

Volume 20, 2024

Published on: 15 March, 2024

Article ID: e15734056288517 Pages: 11

DOI: 10.2174/0115734056288517240221113847

open_access

Open Access Journals Promotions 2
Abstract

Background: Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) is considered a potential marker of hepatic fibrosis (HF).

Objective: To explore the influencing factors of repeatability and reliability in IVIM-DWI parameters of ROI-based liver segments in participants with HF and healthy volunteers (HV) and to assess the diagnostic efficiency of these parameters in HF.

Methods: Participants with early HF (EHF, n=59) or advanced HF (AHF, n=38) and HV (n=48) were recruited. Two examiners measured IVIM data using mono-, bi-exponential and stretched exponential models. The results and influencing factors of repeatability and reliability of IVIM-DWI, and the diagnostic efficiency were analyzed.

Results: The repeatability of D* (CV: 26.62–41.47%) and DDC (CV: 18.01–34.40%) was poor, the repeatability of ADC (CV: 4.95–9.76%), D (CV: 7.09–15.52%), f (CV: 9.35–17.15%), and α (CV: 7.48–13.81%) was better; ordered logistic regression showed statistically significant results of IVIM-derived parameters; the reliability showed no obvious trend, and ordered logistic regression showed statistically significant results of IVIMderived parameters, groups, and partial hepatic segments (all p<0.001). IVIM-derived parameters with relatively good repeatability (CV<20%) and reliability (ICC>0.4) were used to establish regression models for differential diagnosis. The AUC of regression models was 0.744–0.783 (EHF vs. AHF), but no statistically significant parameters were found in the HV vs EHF comparison.

Conclusion: IVIM-derived parameters were the most important factors affecting the repeatability and reliability, while staging of HF and hepatic segments may be the influencing factors of reliability. IVIM-derived parameters showed medium diagnostic efficiency in distinguishing between EHF and AHF.

Keywords: : Liver segment, Diffusion weighted imaging, Hepatic fibrosis, Repeatability, Reliability, IVIM-DWI.


© 2024 Bentham Science Publishers | Privacy Policy