Evaluation of Urinary Interleukin-18 Changes in Patients Treated with Vancomycin

Title:Evaluation of Urinary Interleukin-18 Changes in Patients Treated with Vancomycin

Volume: 5

Author(s): Anoush Azarfar, Yalda Ravanshad, Alireza Ataei Nakhaei, Kimia Mirfendereski and Toktam Kheirabadi*

Affiliation:

• Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Keywords: Acute tubular necrosis, Kidney interleukin-18, Urinary, Vancomycin, Acute kidney injury, Acute tubular necrosis.

Abstract:

Background: Vancomycin, used to treat severe gram-positive infections, can induce acute kidney injury. Some evidence introduced Interleukin-18 (IL-18) as an inflammatory mediator of ischemic damage to many organs and urinary IL-18 as a diagnostic biomarker of acute tubular necrosis.

Objective: The current study aimed to evaluate the urinary level of IL-18 after vancomycin therapy.

Methods: This cross-sectional study was conducted on patients under treatment with vancomycin selected from those referred to Dr. Sheikh Hospital, Mashhad, Iran, from 2018-2019. Urinary IL-18 was measured based on nanograms per milliliter using a human IL-18 enzyme-linked immunosorbent assay kit about this cytokine before vancomycin administration and then two days later. All the analyses were performed in SPSS software (version 25), and a P-value less than 0.05 was considered statistically significant.

Results: A total of 36 patients with a mean age of 40.06±36.67 months were included in the study. The mean scores of IL-18 before and after taking vancomycin were 1453.00±555.01 and 1713.00±660.98, respectively. The IL-18 was significantly lower before vancomycin consumption than the level reported after 48 h (P<0.05).

Conclusions: The present study highlighted a higher level of urinary IL-18 after vancomycin treatment, which may indicate kidney injuries. Therefore, it may be considered a potential biomarker of acute tubular necrosis in patients under vancomycin therapy.

Cite this article as:

Azarfar Anoush, Ravanshad Yalda, Ataei Nakhaei Alireza, Mirfendereski Kimia and Kheirabadi Toktam*, Evaluation of Urinary Interleukin-18 Changes in Patients Treated with Vancomycin, New Emirates Medical Journal 2024; 5 : e02506882278713 . https://dx.doi.org/10.2174/0102506882278713240303174153