Title:Review of Phytosomes and Ethosomes: Groundbreaking Approaches for
Delivering the Phytochemical Components of Plants
Volume: 21
Author(s): Asha Raghav, Meenakshi Attri*Hema Chaudhary
Affiliation:
- School of Medical and Allied Science, K. R. Mangalam University, Gurugram-122103, Haryana, India
Keywords:
Phytoconstituents, Phytosomes, Ethosomes, Rotary Evaporation Method, Solvent Evaporation Method, Antisolvent precipitation method, Cold method, Hot Method, Characterization
Abstract: Phytoconstituents have been widely used since ancient times to form a complex with
phospholipids due to their various therapeutic actions. Despite having strong pharmacodynamic efficiency,
numerous phytoconstituents have shown lower in vivo bioavailability and few adverse effects.
Phytochemicals soluble in water exhibit poor absorption, leading to a limited therapeutic impact.
Phytosome nanotechnology overcomes this limitation by creating a bound of phytochemicals
with phospholipids. This method exhibits improved absorption because phytosomes inhibit significant
herbal extract components from being degraded by gastric juices and gut flora. This improves
bioavailability, increases clinical benefit, and ensures delivery to tissues without compromising nutritional
stability. This review also aims to highlight those vesicular systems that could be used in
phytosome technology. Additionally, this review highlights the preparation, advantage, characterization,
applications, and recent development of phytosome and ethosome with a list of recent patents
and marketed formulations and their uses.
