Title:The Correlation between Region-specific Epicardial Adipose Tissue and
Myocardial Ischemia Defined by CT-FFR in Type 2 Diabetes Mellitus Patients
Volume: 20
Author(s): Zheng Wang, Zengfa Huang and Xiang Wang*
Affiliation:
- Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China
Keywords:
Coronary computed tomography, Type 2 diabetes mellitus, Patients, Epicardial adipose tissue, Myocardial ischemia, Fractional flow reserve.
Abstract:
Background:
Epicardial Adipose Tissue (EAT) accumulation is closely associated with the presence and severity of coronary artery disease (CAD), myocardial
ischemia, plaque vulnerability, and major adverse cardiovascular events.
Objective:
The aim of this study was to investigate the correlation between myocardial ischemia defined by computed tomography-derived fractional flow
reserve (CT-FFR) and region-specific EAT in patients with type 2 diabetes mellitus (T2DM).
Methods:
Between January 2022 and May 2023, 200 T2DM patients were randomly selected from the Department of Endocrinology in The Central Hospital
of Wuhan. These patients were divided into two groups based on myocardial ischemia defined by CT-FFR: myocardial ischemia group (152 cases)
and control group (48 cases). Both groups of patients used a post-treatment workstation to measure the thickness of region-specific EAT. Receiver
operating characteristic (ROC) curve analysis and binary logistic regression were used to evaluate the correlation between various parameters and
myocardial ischemia.
Results:
Patients in the myocardial ischemia group had significantly higher values of age, male gender, systolic blood pressure, total cholesterol,
triglycerides, LDL, HDL, fasting blood glucose, fasting insulin, HOMA-IR, EAT thickness in right ventricular wall, left atrioventricular groove,
and superior and inferior interventricular groove. ROC curve analysis results showed that EAT thickness in the left atrioventricular groove had the
largest area under the ROC curve for diagnosing myocardial ischemia (0.837 [95% CI 0.766-0.865]; P < 0.001). Binary logistic regression analysis
showed that EAT thickness in the left atrioventricular groove was an independent risk factor for myocardial ischemia in patients with T2DM (P <
0.05).
Conclusion:
The EAT thickness in the left atrioventricular groove is an independent risk factor for myocardial ischemia in patients with T2DM. Adipose tissue
in the left atrioventricular groove region plays a major role in EAT-mediated CAD.
