Title:Promising Phytoconstituents in Diabetes-related Wounds: Mechanistic Insights and Implications
Volume: 21
Issue: 2
Author(s): Arjina Sultana, Ranadeep Borgohain, Ashwini Rayaji, Dipankar Saha and Bhrigu Kumar Das*
Affiliation:
- Department of Pharmacology, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Azara,
Guwahati 781017, Assam, India
Keywords:
Diabetes, wound healing, phytoconstituents, neovascularization, natural products, diabetic foot ulcer.
Abstract:
Background: The onset of diabetes mellitus (DM), a metabolic disorder characterized
by high blood glucose levels and disrupted glucose metabolism, results in 20% of people with
diabetes suffering from diabetes-related wounds worldwide. A minor wound, such as a cut or
abrasion, can lead to infections and complications in diabetic patients. We must understand the
mechanism/s contributing to this delayed wound healing to develop effective prevention strategies.
The potential benefits of bioactive phytochemicals for diabetic wound healing have been
reported in numerous studies.
Method: A bioactive compound may have multiple actions, including antioxidants, antiinflammatory,
antimicrobial, and angiogenesis. Compounds derived from these plants have
shown promising results in wound healing, inflammation reduction, collagen synthesis, and neovascularization
improvement.
Results: Consequently, this review provides an update to our understanding of how phytoconstituents
promote wound healing in diabetics. A thorough literature review was conducted on diabetes,
wound healing, and phytoconstituents for this study. Only English publications until June
2023 were included in the search, which used multiple search engines and the main keywords.
Summing up, phytochemical-based interventions might improve the quality of life for diabetics
by improving wound healing.
Conclusion: However, to fully understand the efficacy and safety of these phytochemicals in
managing diabetic wounds, more research and clinical trials are needed.
