Title:4D Flow MRI of Portal Vein Hemodynamics in Healthy Volunteers and Patients
with Chronic Liver Disease
Volume: 20
Author(s): Mengmeng Zhang*, Hailong Yu, Di Zhao, Wen Shen, Xu Bai, Meng Zheng, Jiachen Ji, Rui Li, Jianming Cai, Jinghui Dong*Changchun Liu*
Affiliation:
- Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
- Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
- Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Keywords:
: Chronic liver disease, Cirrhosis, Portal vein, 4D flow MRI, Hemodynamics, Patients
Abstract:
Aim:
To identify age-matched healthy volunteers, non-cirrhotic chronic liver disease (CLD) and cirrhotic patients based on portal hemodynamic
parameters using 4D flow MRI.
Methods:
A total of 10 age-matched healthy volunteers and 69 CLD patients were enrolled and underwent 4D flow MRI prospectively. 4D flow MR images
were processed by an MD in biomedical engineering working on the GTFlow platform. Portal hemodynamic parameters include net flow
(mL/cycle), flow volume per second through the lumen (mL/sec), average flow velocity (cm/sec), and maximum flow velocity (cm/sec). The
difference in portal hemodynamic parameters of 4D flow MRI was compared among healthy volunteers, non-cirrhotic CLD patients and patients
with cirrhosis by one-way ANOVA or Kruskal-Wallis nonparametric test and post hoc tests.
Results:
10 CLD patients without cirrhosis and 56 patients with cirrhosis were eventually included, along with 10 healthy volunteers who were divided into
three groups. 3 patients with cirrhosis whose image quality did not meet the requirements were excluded. There were no significant differences in
portal hemodynamic parameters among the three groups except portal average velocity (P > 0.05). There was no statistical difference in all portal
hemodynamic parameters of 4D flow MRI between healthy volunteers and patients with cirrhosis (P > 0.05). There were significant differences in
portal average velocity between non-cirrhotic CLD patients, healthy volunteers and patients with cirrhosis, respectively (11.44±3.93 vs 8.10±2.66,
P=0.013; 11.44±3.93 vs 8.60±2.22, P=0.007).
Conclusion:
Portal average velocity obtained by 4D flow MRI can be an auxiliary means to identify cirrhosis in patients with CLD.
