Title:Transfersomes: Recent Advances, Mechanisms, Exhaustive Applications,
Clinical Trials, and Patents
Volume: 21
Author(s): Deeksha Manchanda, Manish Makhija, Parijat Pandey and Manu Sharma*
Affiliation:
- Department of Pharmacy, Banasthali Vidyapith, Rajasthan-304022, India
Keywords:
Transfersomes, ultra-deformability, flexibility, phospholipids, edge activator, applications
Abstract: A feasible nano transdermal delivery system generally intends to have specific ideal and distinct characteristics
primarily for safety, clinical efficacy, and boosted therapeutic index. The delivery of drugs, particularly
macromolecules, across the skin is one of the most strenuous obstacles in front of pharmaceutical scientists.
Technology advancement has provided some opportunities to overcome this difficulty by utilising microneedle
arrays, ablation, laser methods etc. However, associated uneasiness, painful sensation, and higher cost of
therapies limit their day-to-day use. Therefore, researchers have focused on developing alternate carriers like
ultra-deformable liposomes, also termed transfersomes. Transfersomes are composed of a lipid bilayer containing
phospholipids and an edge activator to facilitate drug delivery via transdermal route to deeper layers of
skin and for higher systemic bioavailability. The bilayer structure of transfersomes allows ease of encapsulation
of both hydrophilic and lipophilic drugs with higher permeability than typical liposomes. Therefore,
among various vesicular systems, transfersomes have developed much interest in targeted and sustained drug
delivery. The current review primarily emphasizes critical aspects of transfersomes, including their applications,
clinical trial studies, and patents found in various literature sources.
