Title:Mild and Efficient Preparation of N-Heterocyclic Organic Molecules by Catalyst-free and Solvent-free Methods
Volume: 22
Issue: 2
Author(s): Zhiqiang Wu*, Xuesong Li, Yueyi Li, Lin-an Cao, Zhenliang Li, Xuming Wang, Wanyi Liu and Enke Feng*
Affiliation:
- School of Chemistry and Chemical Engineering; Key Laboratory of Green Catalytic Materials and Technology of Ningxia Province, Ningxia Normal University, Guyuan, 756000, P. R. China
- School of Civil and Hydraulic Engineering, Ningxia University, Yinchuan, 750021, P. R. China
- School of Chemistry and Chemical Engineering; Key Laboratory of Green Catalytic Materials and Technology of Ningxia Province, Ningxia Normal University, Guyuan, 756000, P. R. China
Keywords:
Catalyst-free, solvent-free, organic small molecules, synthetic preparation, N-heterocyclic derivatives, hydrothermal.
Abstract:
Aims: The small organic molecular compounds with biological activity containing
C-C and C-N or C-O bonding were efficiently prepared without catalyst and solvent in the
hydrothermal synthesis reactor.
Objectives: Our goal was to explore new applications for the more environmentally friendly
and efficient synthesis of bis(indolyl)methyl, xanthene, quinazolinone, and N-heterocyclic
derivatives in hydrothermal synthesis reactors under solvent-free and catalyst-free conditions.
Methods: A greener and more efficient method was successfully developed for the synthesis of
bis(indolyl)methyl, heteroanthracene, quinazolinone, and N-heterocyclic derivatives using a
hydrothermal synthesis reactor in a solvent- and catalyst-free manner.
Results: In a hydrothermal synthesis reactor, bis(indoyl)methyl, xanthene, quinazolinone, and
N-heterocyclic derivatives were synthesized without catalysts and solvents.
Conclusion: Overall, it is proved once again that the catalyst-free and solvent-free synthesis
method has universal value and is a more ideal and environmentally friendly new method,
especially the hydrothermal reactor for synthesis.
