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Endocrine, Metabolic & Immune Disorders - Drug Targets

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Systematic Review Article

A Systematic Narrative Review on ADIPOQ Gene Variants and its Association with T2DM in the Indian Population

Author(s): Mohammad Danish Khan, Rohit Kumar Srivastava, Tarun Kumar Upadhyay and Mohammad Mustufa Khan*

Volume 24, Issue 10, 2024

Published on: 07 February, 2024

Page: [1161 - 1168] Pages: 8

DOI: 10.2174/0118715303257835231117062928

Price: $65

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Abstract

Background: The prevalence of diabetes is rapidly increasing in India, even among young adult individuals. Rare adiponectin gene (ADIPOQ) variants may be predominantly present in Indians and decrease the circulatory levels of APN (Adiponectin). Studies reported that ADIPOQ gene variants were associated with type 2 diabetes mellitus (T2DM) and its complications in the Indian population.

Objectives: To review the association of specific ADIPOQ gene variants with T2DM and its associated complications.

Materials & Methods: A search of Pubmed, Chinhal, Medline, Scopus, Web of Science databases, and Google Scholar search engine was performed to retrieve articles by using the following keywords; “ADIPOQ and T2DM”, “ADIPOQ and India,” “ADIPOQ gene variants and T2DM”, “ADIPOQ gene variants and T2DM and India”, “SNPs of ADIPOQ gene and T2DM”, “SNPs of ADIPOQ gene and India,” SNPs of ADIPOQ gene and T2DM and India”. Eligibility criteria for the inclusion of articles: Original, Case-Control Study, and Full-Text articles were published in the English language till the end of April 2023.

Results: A total of 540 articles were retrieved. Out of this, only 18 articles were found suitable to include in this systematic narrative review. The most studied ADIPOQ gene variants were found to be +10211T/G (rs17846866), +45T/G (rs2241766), and +276G/T (rs1501299) in different Indian populations.

Conclusion: It was reviewed that ADIPOQ gene variants +10211T/G (rs17846866), +45T/G (rs2241766), and +276G/T (rs1501299) were predominantly present in the Indian population, and decreasing the circulatory levels of APN and significantly associated with T2DM and its complications.<

Keywords: ADIPOQ gene, ADIPOQ gene variants, adiponectin, SNPs, type 2 diabetes mellitus, the Indian population.

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Graphical Abstract

[1]
Mohan, V.; Pradeepa, R. Epidemiology of type 2 diabetes in India. Indian J. Ophthalmol., 2021, 69(11), 2932-2938.
[http://dx.doi.org/10.4103/ijo.IJO_1627_21] [PMID: 34708726]
[2]
Mathur, P.; Leburu, S.; Kulothungan, V. Prevalence, awareness, treatment and control of diabetes in India from the countrywide National NCD Monitoring Survey. Front. Public Health, 2022, 10, 748157.
[http://dx.doi.org/10.3389/fpubh.2022.748157] [PMID: 35359772]
[3]
Siddiqui, M.K.; Anjana, R.M.; Dawed, A.Y.; Martoeau, C.; Srinivasan, S.; Saravanan, J.; Madanagopal, S.K.; Taylor, A.; Bell, S.; Veluchamy, A.; Pradeepa, R.; Sattar, N.; Venkatesan, R.; Palmer, C.N.A.; Pearson, E.R.; Mohan, V. Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function. Diabetologia, 2022, 65(6), 973-983.
[http://dx.doi.org/10.1007/s00125-022-05671-z] [PMID: 35247066]
[4]
Mohan, V.; Sandeep, S.; Deepa, R.; Shah, B.; Varghese, C. Epidemiology of type 2 diabetes: Indian scenario. Indian J. Med. Res., 2007, 125(3), 217-230.
[PMID: 17496352]
[5]
Unnikrishnan, R.; Anjana, R.M.; Mohan, V. Diabetes in South Asians: Is the phenotype different? Diabetes, 2014, 63(1), 53-55.
[http://dx.doi.org/10.2337/db13-1592] [PMID: 24357697]
[6]
Anjana, R.M.; Baskar, V.; Nair, A.T.N.; Jebarani, S.; Siddiqui, M.K.; Pradeepa, R.; Unnikrishnan, R.; Palmer, C.; Pearson, E.; Mohan, V. Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: A data-driven cluster analysis: The INSPIRED study. BMJ Open Diabetes Res. Care, 2020, 8(1), e001506.
[http://dx.doi.org/10.1136/bmjdrc-2020-001506] [PMID: 32816869]
[7]
Abate, N.; Chandalia, M.; Snell, P.G.; Grundy, S.M. Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men. J. Clin. Endocrinol. Metab., 2004, 89(6), 2750-2755.
[http://dx.doi.org/10.1210/jc.2003-031843] [PMID: 15181053]
[8]
Snehalatha, C.; Yamuna, A.; Ramachandran, A. Plasma adiponectin does not correlate with insulin resistance and cardiometabolic variables in nondiabetic Asian Indian teenagers. Diabetes Care, 2008, 31(12), 2374-2379.
[http://dx.doi.org/10.2337/dc08-1083] [PMID: 18809626]
[9]
Kadowaki, T.; Yamauchi, T. Adiponectin and adiponectin receptors. Endocr. Rev., 2005, 26(3), 439-451.
[http://dx.doi.org/10.1210/er.2005-0005] [PMID: 15897298]
[10]
Lara-Castro, C.; Luo, N.; Wallace, P.; Klein, R.L.; Garvey, W.T. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes, 2006, 55(1), 249-259.
[http://dx.doi.org/10.2337/diabetes.55.01.06.db05-1105] [PMID: 16380500]
[11]
Hara, K.; Horikoshi, M.; Yamauchi, T.; Yago, H.; Miyazaki, O.; Ebinuma, H.; Imai, Y.; Nagai, R.; Kadowaki, T. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care, 2006, 29(6), 1357-1362.
[http://dx.doi.org/10.2337/dc05-1801] [PMID: 16732021]
[12]
Kottyan, L.C.; Woo, J.G.; Keddache, M.; Banach, W.; Crimmins, N.A.; Dolan, L.M.; Martin, L.J. Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes. Springerplus, 2012, 1(1), 66.
[http://dx.doi.org/10.1186/2193-1801-1-66] [PMID: 23396303]
[13]
Torres-Castillo, N.; Campos-Perez, W.; Rodriguez-Echevarria, R.; Rodriguez-Reyes, S.C.; Martinez-Lopez, E. A metabolically unhealthy phenotype is associated with ADIPOQ genetic variants and lower serum adiponectin levels. Lifestyle Genomics, 2020, 13(6), 172-179.
[http://dx.doi.org/10.1159/000510021] [PMID: 33137807]
[14]
Kondo, H.; Shimomura, I.; Matsukawa, Y.; Kumada, M.; Takahashi, M.; Matsuda, M.; Ouchi, N.; Kihara, S.; Kawamoto, T.; Sumitsuji, S.; Funahashi, T.; Matsuzawa, Y. Association of adiponectin mutation with type 2 diabetes: A candidate gene for the insulin resistance syndrome. Diabetes, 2002, 51(7), 2325-2328.
[http://dx.doi.org/10.2337/diabetes.51.7.2325] [PMID: 12086969]
[15]
Simeone, C.A.; Wilkerson, J.L.; Poss, A.M.; Banks, J.A.; Varre, J.V.; Guevara, J.L.; Hernandez, E.J.; Gorsi, B.; Atkinson, D.L.; Turapov, T.; Frodsham, S.G.; Morales, J.C.F.; O’Neil, K.; Moore, B.; Yandell, M.; Summers, S.A.; Krolewski, A.S.; Holland, W.L.; Pezzolesi, M.G. A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia. NPJ Genom. Med., 2022, 7(1), 43.
[http://dx.doi.org/10.1038/s41525-022-00314-z] [PMID: 35869090]
[16]
Vimaleswaran, K.S.; Radha, V.; Ramya, K.; Babu, H.N.S.; Savitha, N.; Roopa, V.; Monalisa, D.; Deepa, R.; Ghosh, S.; Majumder, P.P.; Rao, M.R.S.; Mohan, V. A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians. Hum. Genet., 2008, 123(6), 599-605.
[http://dx.doi.org/10.1007/s00439-008-0506-8] [PMID: 18465144]
[17]
Saxena, M.; Srivastava, N.; Banerjee, M. Genetic association of adiponectin gene polymorphisms (+45T/G and +10211T/G) with type 2 diabetes in North Indians. Diabetes Metab. Syndr., 2012, 6(2), 65-69.
[http://dx.doi.org/10.1016/j.dsx.2012.08.008] [PMID: 23153972]
[18]
Gupta, A.C.; Misra, R.; Sakhuja, P.; Singh, Y.; Basir, S.F.; Sarin, S.K. Association of adiponectin gene functional polymorphisms (− 11377C/G and + 45T/G) with nonalcoholic fatty liver disease. Gene, 2012, 496(1), 63-67.
[http://dx.doi.org/10.1016/j.gene.2011.12.023] [PMID: 22269154]
[19]
Ramya, K.; Ayyappa, K.A.; Ghosh, S.; Mohan, V.; Radha, V. Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population. Gene, 2013, 532(2), 253-262.
[http://dx.doi.org/10.1016/j.gene.2013.09.012] [PMID: 24055485]
[20]
Khan, M.M.; Sonkar, G.K.; Alam, R.; Singh, S.; Mehrotra, S.; Sonkar, S.K. Association of ADIPOQ gene variant rs266729 with circulatory adiponectin levels in patients with Type 2 diabetes in north indian population: A case-control study. Biomed. Pharmacol. J., 2017, 10(1), 407-417.
[http://dx.doi.org/10.13005/bpj/1123]
[21]
Khan, M.M.; Alam, R. Association of +10211T/G (Rs17846866) variant of adiponectin gene with type 2 diabetes mellitus. Biosci. Biotechnol. Res. Asia, 2019, 16(3), 569-576.
[http://dx.doi.org/10.13005/bbra/2772]
[22]
Biswas, D.; Vettriselvi, V.; Choudhury, J.; Jothimalar, R. Adiponectin gene polymorphism and its association with type 2 diabetes mellitus. Indian J. Clin. Biochem., 2011, 26(2), 172-177.
[http://dx.doi.org/10.1007/s12291-011-0123-5] [PMID: 22468045]
[23]
Matharoo, K.; Arora, P.; Bhanwer, A.J.S. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab. Gene, 2013, 527(1), 228-234.
[http://dx.doi.org/10.1016/j.gene.2013.05.075] [PMID: 23764562]
[24]
Irgam, K.; Reddy, B.S.; Hari, S.G.; Banapuram, S.; Reddy, B.M. The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad. BMC Med. Genomics, 2021, 14(1), 272.
[http://dx.doi.org/10.1186/s12920-021-01129-0] [PMID: 34784930]
[25]
Palit, S.P.; Patel, R.; Jadeja, S.D.; Rathwa, N.; Mahajan, A.; Ramachandran, A.V.; Dhar, M.K.; Sharma, S.; Begum, R. A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes. Sci. Rep., 2020, 10(1), 2904.
[http://dx.doi.org/10.1038/s41598-020-59845-z] [PMID: 32076038]
[26]
Vasseur, F.; Helbecque, N.; Dina, C.; Lobbens, S.; Delannoy, V.; Gaget, S.; Boutin, P.; Vaxillaire, M.; Leprêtre, F.; Dupont, S.; Hara, K.; Clément, K.; Bihain, B.; Kadowaki, T.; Froguel, P. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum. Mol. Genet., 2002, 11(21), 2607-2614.
[http://dx.doi.org/10.1093/hmg/11.21.2607] [PMID: 12354786]
[27]
Cortelazzi, D.; Corbetta, S.; Ronzoni, S.; Pelle, F.; Marconi, A.; Cozzi, V.; Cetin, I.; Cortelazzi, R.; Beck-Peccoz, P.; Spada, A. Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clin. Endocrinol. (Oxf.), 2007, 66(3), 447-453.
[http://dx.doi.org/10.1111/j.1365-2265.2007.02761.x] [PMID: 17302882]
[28]
Jungtrakoon, P.; Plengvidhya, N.; Tangjittipokin, W.; Chimnaronk, S.; Salaemae, W.; Chongjaroen, N.; Chanprasert, K.; Sujjitjoon, J.; Srisawat, C.; Yenchitsomanus, P. Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects. PLoS One, 2011, 6(10), e26792.
[http://dx.doi.org/10.1371/journal.pone.0026792] [PMID: 22046359]
[29]
Comuzzie, A.G.; Funahashi, T.; Sonnenberg, G.; Martin, L.J.; Jacob, H.J.; Black, A.E.K.; Maas, D.; Takahashi, M.; Kihara, S.; Tanaka, S.; Matsuzawa, Y.; Blangero, J.; Cohen, D.; Kissebah, A. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J. Clin. Endocrinol. Metab., 2001, 86(9), 4321-4325.
[http://dx.doi.org/10.1210/jcem.86.9.7878] [PMID: 11549668]
[30]
Khan, M.; Khan, M.D.; Ahmad, M.K.; Alam, R.; Khan, S.; Jaiswal, G. Association of circulatory adiponectin with the parameters of Madras Diabetes Research Foundation-Indian Diabetes Risk Score. J. Diabetol., 2022, 13(4), 331.
[http://dx.doi.org/10.4103/jod.jod_86_22]
[31]
Mohan, V.; Gokulakrishnan, K.; Deepa, R.; Shanthirani, C.S.; Datta, M. Association of physical inactivity with components of metabolic syndrome and coronary artery disease-the Chennai Urban Population Study (CUPS no. 15). Diabet. Med., 2005, 22(9), 1206-1211.
[http://dx.doi.org/10.1111/j.1464-5491.2005.01616.x] [PMID: 16108850]
[32]
Mohan, V.; Shanthi Rani, C.S.; Amutha, A.; Dhulipala, S.; Anjana, R.M.; Parathasarathy, B.; Unnikrishnan, R. Clinical profile of long-term survivors and nonsurvivors with type 2 diabetes. Diabetes Care, 2013, 36(8), 2190-2197.
[http://dx.doi.org/10.2337/dc12-1193] [PMID: 23564913]
[33]
Sonkar, S.K.; Khan, M.M.; Sonkar, G.K.; Alam, R.; Mehrotra, S.; Khan, M.S.; Kumar, A. Validity of Indian Diabetes Risk Score and its association with body mass index and glycosylated hemoglobin for screening of diabetes in and around areas of Lucknow. J. Family Med. Prim. Care, 2017, 6(2), 366-373.
[http://dx.doi.org/10.4103/2249-4863.220010] [PMID: 29302549]
[34]
Khan, M.M.; Sonkar, G.K.; Singh, S.; Sonkar, S.K. Importance of the Madras Diabetes Research Foundation-Indian Diabetes Risk Score (MDRF-IDRS) for mass screening of type 2 diabetes and its complications at primary health care centers of North India. Int. J. Diabetes Dev. Ctries., 2019, 39(3), 419-425.
[http://dx.doi.org/10.1007/s13410-018-0710-6]
[35]
Sanghera, D.K.; Demirci, F.Y.; Been, L.; Ortega, L.; Ralhan, S.; Wander, G.S.; Mehra, N.K.; Singh, J.; Aston, C.E.; Mulvihill, J.J.; Kamboh, I.M. PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor. Metabolism, 2010, 59(4), 492-501.
[http://dx.doi.org/10.1016/j.metabol.2009.07.043] [PMID: 19846176]
[36]
Sikka, R.; Raina, P.; Matharoo, K.; Bandesh, K.; Bhatia, R.; Chakrabarti, S.; Bhanwer, A.J.S. TNF-α (g.-308 G > A) and ADIPOQ (g. + 45 T > G) gene polymorphisms in type 2 diabetes and microvascular complications in the region of Punjab (North-West India). Curr. Eye Res., 2014, 39(10), 1042-1051.
[http://dx.doi.org/10.3109/02713683.2014.892998] [PMID: 24655058]
[37]
Phani, N.M.; Vohra, M.; Rajesh, S.; Adhikari, P.; Nagri, S.K.; D’Souza, S.C.; Satyamoorthy, K.; Rai, P.S. Implications of critical PPARγ2, ADIPOQ and FTO gene polymorphisms in type 2 diabetes and obesity-mediated susceptibility to type 2 diabetes in an Indian population. Mol. Genet. Genomics, 2016, 291(1), 193-204.
[http://dx.doi.org/10.1007/s00438-015-1097-4] [PMID: 26243686]
[38]
Momin, A.A.; Bankar, M.P.; Bhoite, G.M. Association of single nucleotide polymorphisms of adiponectin gene with type 2 diabetes mellitus, and their influence on cardiovascular risk markers. Indian J. Clin. Biochem., 2017, 32(1), 53-60.
[http://dx.doi.org/10.1007/s12291-016-0573-x] [PMID: 28149013]
[39]
Srivastava, N.; Prakash, J.; Mittal, B.; Awasthi, S. Association of adiponectin gene polymorphism with adiponectin levels and risk for insulin resistance syndrome. Int. J. Prev. Med., 2015, 6(1), 31.
[http://dx.doi.org/10.4103/2008-7802.154773] [PMID: 25949781]
[40]
Kaur, H.; Badaruddoza, B.; Bains, V.; Kaur, A. Genetic association of ADIPOQ gene variants (-3971A>G and +276G>T) with obesity and metabolic syndrome in North Indian Punjabi population. PLoS One, 2018, 13(9), e0204502.
[http://dx.doi.org/10.1371/journal.pone.0204502] [PMID: 30265726]
[41]
Bains, V.; Kaur, H. Badaruddoza, Association study of the single‐nucleotide polymorphisms −3971G/A and +276G/T in the adiponectin gene with type 2 diabetes in a North Indian Punjabi population. Ann. Hum. Genet., 2020, 84(3), 235-248.
[http://dx.doi.org/10.1111/ahg.12366] [PMID: 31755094]
[42]
Amrita, J.; Mahajan, M.; Bhanwer, A.J.S.; Matharoo, K. Association of AdipoQ gene variation (rs1501299) and oxidative stress with cardiovascular disease in North West Indian population of Punjabi women. J. Med. Biochem., 2021, 40(1), 49-59.
[http://dx.doi.org/10.5937/jomb0-24704] [PMID: 33584140]
[43]
Tu, Y.; Yu, Q.; Fan, G.; Yang, P.; Lai, Q.; Yang, F.; Zhang, S.; Wang, W.; Wang, D.; Yu, X.; Wang, C.Y. Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses. Mol. Cell. Endocrinol., 2014, 396(1-2), 1-9.
[http://dx.doi.org/10.1016/j.mce.2014.08.006] [PMID: 25135112]
[44]
Alimi, M.; Goodarzi, M.T.; Nekoei, M. Association of ADIPOQ rs266729 and rs1501299 gene polymorphisms and circulating adiponectin level with the risk of type 2 diabetes in a population of Iran: A case-control study. J. Diabetes Metab. Disord., 2021, 20(1), 87-93.
[http://dx.doi.org/10.1007/s40200-020-00715-w] [PMID: 34222061]
[45]
Zhou, J.M.; Zhang, M.; Wang, S.; Wang, B.Y.; Han, C.Y.; Ren, Y.C.; Zhang, L.; Zhang, H.Y.; Yang, X.Y.; Zhao, Y.; Hu, D.S. Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese Population: A Meta-analysis. Biomed. Environ. Sci., 2016, 29(7), 505-515.
[http://dx.doi.org/10.3967/bes2016.066] [PMID: 27554120]
[46]
Ukkola, O.; Santaniemi, M.; Rankinen, T.; Leon, A.S.; Skinner, J.S.; Wilmore, J.H.; Rao, D.C.; Bergman, R.; Antero Kesäniemi, Y.; Bouchard, C. Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study. Ann. Med., 2005, 37(2), 141-150.
[http://dx.doi.org/10.1080/07853890510007241] [PMID: 16028335]

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