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Current Cancer Therapy Reviews

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ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

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Review Article

Anti-cancer Potential of Phytoflavonoidal Drugs against Gynecological Cancer

Author(s): Kavita Sangwan* and Parveen Kumar Goyal

Volume 21, Issue 2, 2025

Published on: 07 February, 2024

Page: [213 - 228] Pages: 16

DOI: 10.2174/0115733947289878240126111236

Price: $65

Abstract

Background: Flavonoids, one of the major bioactive constituents of herbal drugs, have been scientifically reported to possess diverse therapeutic potentials such as anticancer, immunomodulatory, neuroprotective, cardioprotective, antioxidant, etc. This manuscript enlightens the anticancer potential of traditional herbal flavonoids in gynecological cancer i.e., is one of the major life-threats in women.

Objective: This manuscript is aimed at an insightful compilation of scientific substantiations of herbal flavonoids in gynecological cancer along with targeted drug delivery systems for the same.

Materials and Methods: The contents and data represented in the article have been reviewed using institutional libraries and online database resources (available in the public domain) such as PubMed, Science-Direct, Web of Science, American Association of Pharmaceutical Scientists, Google Scholar, Hinari, SciFinder, Research Gate, etc.

Results: Flavonoids are natural compounds and have potential against cervical, ovarian, and endometrial cancer. In-vitro and in-vivo experiments have demonstrated the significant potential of flavonoids in gynecological cancer, especially cervical, ovarian, and endometrial cancer. It was reported from in-vitro experimentations that targeted drug delivery system improves the anticancer effect of flavonoids.

Conclusion: Phytoflavonoids have the potential to prevent gynecological cancer by induction of apoptosis cell cycle arrest and reactive oxygen species generation. Further studies on the drug delivery system of flavonoids are warranted.

Keywords: Phytoflavonoids, gyenocological cancer, drug delivery system, cervical cancer, ovarian cancer, endometrial cancer.

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[1]
Chang K, Gunter MJ, Rauber F, et al. Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank. EClinicalMedicine 2023; 56: 101840.
[http://dx.doi.org/10.1016/j.eclinm.2023.101840] [PMID: 36880051]
[2]
Chang K, Millett C, Rauber F, et al. Ultra-processed food consumption, cancer risk, and cancer mortality: A prospective cohort study of the UK Biobank. Lancet 2022; 400: S31.
[http://dx.doi.org/10.1016/S0140-6736(22)02241-3]
[3]
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61(2): 69-90.
[http://dx.doi.org/10.3322/caac.20107] [PMID: 21296855]
[4]
Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014; 515(7528): 563-7.
[http://dx.doi.org/10.1038/nature14011] [PMID: 25428504]
[5]
Chinnikrishnan P, Aziz Ibrahim IA, Alzahrani AR, Shahzad N, Sivaprakasam P, Pandurangan AK. The role of selective flavonoids on triple-negative breast cancer: An update. Separations 2023; 10(3): 207.
[http://dx.doi.org/10.3390/separations10030207]
[6]
Maheshwari A, Kumar N, Mahantshetty U. Gynecological cancers: A summary of published Indian data. South Asian J Cancer 2016; 5(3): 112-20.
[http://dx.doi.org/10.4103/2278-330X.187575] [PMID: 27606294]
[7]
Block KI, Gyllenhaal C, Lowe L, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol 2015; 35(Suppl)(Suppl.): S276-304.
[http://dx.doi.org/10.1016/j.semcancer.2015.09.007] [PMID: 26590477]
[8]
Goyal PK, Vats S. Polymer-Drug Conjugates. Academic Press 2023; pp. 279-313.
[http://dx.doi.org/10.1016/B978-0-323-91663-9.00002-3]
[9]
Jang SH, Wientjes MG, Lu D, Au JLS. Drug delivery and transport to solid tumors. Pharm Res 2003; 20(9): 1337-50.
[http://dx.doi.org/10.1023/A:1025785505977] [PMID: 14567626]
[10]
Kanarek N, Petrova B, Sabatini DM. Dietary modifications for enhanced cancer therapy. Nature 2020; 579(7800): 507-17.
[http://dx.doi.org/10.1038/s41586-020-2124-0] [PMID: 32214253]
[11]
Nwodo JN, Ibezim A, Simoben CV, Ntie-Kang F. Exploring cancer therapeutics with natural products from African medicinal plants, Part II: Alkaloids, terpenoids and flavonoids. Anticancer Agents Med Chem 2016; 16(1): 108-27.
[http://dx.doi.org/10.2174/1871520615666150520143827] [PMID: 25991425]
[12]
Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J. Flavonoids as anticancer agents. Nutrients 2020; 12(2): 457.
[http://dx.doi.org/10.3390/nu12020457] [PMID: 32059369]
[13]
Bondonno NP, Dalgaard F, Kyrø C, et al. Flavonoid intake is associated with lower mortality in the danish diet cancer and health cohort. Nat Commun 2019; 10(1): 3651.
[http://dx.doi.org/10.1038/s41467-019-11622-x] [PMID: 31409784]
[14]
Efferth T, Saeed MEM, Kadioglu O, et al. Collateral sensitivity of natural products in drug-resistant cancer cells. Biotechnol Adv 2020; 38: 107342.
[http://dx.doi.org/10.1016/j.biotechadv.2019.01.009] [PMID: 30708024]
[15]
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin 2021; 71(1): 7-33.
[http://dx.doi.org/10.3322/caac.21654] [PMID: 33433946]
[16]
Farrand L, Oh SW, Song YS, Tsang BK. Phytochemicals: A multitargeted approach to gynecologic cancer therapy. BioMed Res Int 2014; 2014: 1-10.
[http://dx.doi.org/10.1155/2014/890141] [PMID: 25093186]
[17]
Cibula D, Raspollini MR, Planchamp F, et al. ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer – Update 2023. Virchows Arch 2023; 482(6): 935-66.
[http://dx.doi.org/10.1007/s00428-023-03552-3] [PMID: 37145263]
[18]
Zhu Y, Wang L, Xu L, Ying P. A network pharmacology study on the cervix prescription for treatment of cervical cancer. J Immunol Res 2022; 2022: 1-13.
[http://dx.doi.org/10.1155/2022/8945591] [PMID: 36277473]
[19]
Gaffney DK, Hashibe M, Kepka D, Maurer KA, Werner TL. Too many women are dying from cervix cancer: Problems and solutions. Gynecol Oncol 2018; 151(3): 547-54.
[http://dx.doi.org/10.1016/j.ygyno.2018.10.004] [PMID: 30301561]
[20]
Akinlotan M, Bolin JN, Helduser J, Ojinnaka C, Lichorad A, McClellan D. Cervical cancer screening barriers and risk factor knowledge among uninsured women. J Community Health 2017; 42(4): 770-8.
[http://dx.doi.org/10.1007/s10900-017-0316-9] [PMID: 28155005]
[21]
Damani M, Baxi K, Aranha C, Sawarkar SP. Recent advances in herbal drug nanocarriers against cervical cancer. Crit Rev Ther Drug Carr Syst 2021; 38(1)
[http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.2020034170]
[22]
Veeramuthu D, Raja WR, Al-Dhabi NA, Savarimuthu I. Flavonoids: Anticancer properties. Crit Rev Ther Drug Carr Syst 2017; 287.
[http://dx.doi.org/10.5772/68095]
[23]
Shafabakhsh R, Asemi Z. Quercetin: A natural compound for ovarian cancer treatment. J Ovarian Res 2019; 12(1): 55.
[http://dx.doi.org/10.1186/s13048-019-0530-4] [PMID: 31202269]
[24]
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69(1): 7-34.
[http://dx.doi.org/10.3322/caac.21551] [PMID: 30620402]
[25]
Di Tucci C, Galati G, Mattei G, Chinè A, Fracassi A, Muzii L. Fertility after Cancer: Risks and successes. Cancers 2022; 14(10): 2500.
[http://dx.doi.org/10.3390/cancers14102500] [PMID: 35626104]
[26]
Razi S, Ghoncheh M, Mohammadian-Hafshejani A, Aziznejhad H, Mohammadian M, Salehiniya H. The incidence and mortality of ovarian cancer and their relationship. Ecancermedicalscience 2016; 10: 628.
[http://dx.doi.org/10.3332/ecancer.2016.628] [PMID: 27110284]
[27]
Stewart C, Ralyea C, Lockwood S. Ovarian cancer: An integrated review. Semin Oncol Nurs 2019; 35(2): 151-6.
[http://dx.doi.org/10.1016/j.soncn.2019.02.001] [PMID: 30867104]
[28]
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71(3): 209-49.
[http://dx.doi.org/10.3322/caac.21660] [PMID: 33538338]
[29]
Evrard C, Alexandre J. Predictive and prognostic value of microsatellite instability in gynecologic cancer (endometrial and ovarian). Cancers 2021; 13(10): 2434.
[http://dx.doi.org/10.3390/cancers13102434] [PMID: 34069845]
[30]
Colombo N, Peiretti M, Parma G, et al. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010; 21: v23-30.
[http://dx.doi.org/10.1093/annonc/mdq244] [PMID: 20555088]
[31]
Korbecki J, Bosiacki M, Barczak K, et al. Involvement in tumorigenesis and clinical significance of CXCl1 in reproductive cancers: Breast cancer, cervical cancer, endometrial cancer, ovarian cancer and prostate cancer. Int J Mol Sci 2023; 24(8): 7262.
[http://dx.doi.org/10.3390/ijms24087262] [PMID: 37108425]
[32]
Wang Q, Peng H, Qi X, Wu M, Zhao X. Targeted therapies in gynecological cancers: A comprehensive review of clinical evidence. Signal Transduct Target Ther 2020; 5(1): 137.
[http://dx.doi.org/10.1038/s41392-020-0199-6] [PMID: 32728057]
[33]
Burmeister CA, Khan SF, Schäfer G, et al. Cervical cancer therapies: Current challenges and future perspectives. Tumour Virus Research 2022; 13: 200238.
[http://dx.doi.org/10.1016/j.tvr.2022.200238] [PMID: 35460940]
[34]
Gautam L, Jain A, Shrivastava P, Vyas S, Vyas SP. Emergence of novel targeting systems and conventional therapies for effective cancer treatment. Nano Drug Delivery Strategies for the Treatment of Cancers 2021; p. 35.
[http://dx.doi.org/10.1016/B978-0-12-819793-6.00002-3]
[35]
Anand U, Dey A, Chandel AKS, et al. Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics. Genes Dis 2023; 10(4): 1367-401.
[http://dx.doi.org/10.1016/j.gendis.2022.02.007] [PMID: 37397557]
[36]
Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: Current advances and future directions. Int J Med Sci 2012; 9(3): 193-9.
[http://dx.doi.org/10.7150/ijms.3635] [PMID: 22408567]
[37]
Najafi M, Tavakol S, Zarrabi A, Ashrafizadeh M. Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: A review. Arch Physiol Biochem 2022; 128(6): 1438-52.
[http://dx.doi.org/10.1080/13813455.2020.1773864] [PMID: 32521182]
[38]
Manson MM. Cancer prevention – the potential for diet to modulate molecular signalling. Trends Mol Med 2003; 9(1): 11-8.
[http://dx.doi.org/10.1016/S1471-4914(02)00002-3] [PMID: 12524205]
[39]
Nabavi SM, Šamec D, Tomczyk M, et al. Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering. Biotechnol Adv 2020; 38: 107316.
[http://dx.doi.org/10.1016/j.biotechadv.2018.11.005] [PMID: 30458225]
[40]
Cahyana Y, Adiyanti T. Flavonoids as antidiabetic agents. Indo J Chem 2021; 21(2): 512-26.
[http://dx.doi.org/10.22146/ijc.58439]
[41]
Abotaleb M, Samuel S, Varghese E, et al. Flavonoids in cancer and apoptosis. Cancers 2018; 11(1): 28.
[http://dx.doi.org/10.3390/cancers11010028] [PMID: 30597838]
[42]
Way TD, Kao MC, Lin JK. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 2004; 279(6): 4479-89.
[http://dx.doi.org/10.1074/jbc.M305529200] [PMID: 14602723]
[43]
Zheng PW, Chiang LC, Lin CC. Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. Life Sci 2005; 76(12): 1367-79.
[http://dx.doi.org/10.1016/j.lfs.2004.08.023] [PMID: 15670616]
[44]
Li Z, Hu X, Wang Y, Fang J. Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1. FEBS Lett 2009; 583(12): 1999-2003.
[http://dx.doi.org/10.1016/j.febslet.2009.05.013] [PMID: 19447105]
[45]
Wu DG, Yu P, Li JW, et al. Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. Toxicol Lett 2014; 224(1): 157-64.
[http://dx.doi.org/10.1016/j.toxlet.2013.10.007] [PMID: 24148603]
[46]
Subhasitanont P, Chokchaichamnankit D, Chiablaem K, et al. Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett 2017; 14(4): 4361-71.
[http://dx.doi.org/10.3892/ol.2017.6705] [PMID: 28943950]
[47]
Tong J, Shen Y, Zhang Z, Hu Y, Zhang X, Han L. Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway. Biosci Rep 2019; 39(5): BSR20190452.
[http://dx.doi.org/10.1042/BSR20190452] [PMID: 30967496]
[48]
Liu Q, Chen X, Yang G, Min X, Maoxian Deng A. Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells. Biocell 2011; 35(3): 71-80.
[http://dx.doi.org/10.32604/biocell.2011.35.071] [PMID: 22423483]
[49]
Gao AM, Zhang XY, Hu JN, Ke ZP. Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. Chem Biol Interact 2018; 280: 45-50.
[http://dx.doi.org/10.1016/j.cbi.2017.11.020] [PMID: 29191453]
[50]
Meng S, Zhu Y, Li JF, et al. Apigenin inhibits renal cell carcinoma cell proliferation. Oncotarget 2017; 8(12): 19834-42.
[http://dx.doi.org/10.18632/oncotarget.15771] [PMID: 28423637]
[51]
Zhu H, Jin H, Pi J, et al. Apigenin induced apoptosis in esophageal carcinoma cells by destruction membrane structures. Scanning 2016; 38(4): 322-8.
[http://dx.doi.org/10.1002/sca.21273] [PMID: 26435325]
[52]
Swanson HI, Choi EY, Helton WB, Gairola CG, Valentino J. Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117(2): 214-20.
[http://dx.doi.org/10.1016/j.oooo.2013.10.012] [PMID: 24439916]
[53]
Chen M, Wang X, Zha D, et al. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner. Sci Rep 2016; 6(1): 35468.
[http://dx.doi.org/10.1038/srep35468] [PMID: 27752089]
[54]
Maggioni D, Garavello W, Rigolio R, Pignataro L, Gaini R, Nicolini G. Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis. Int J Oncol 2013; 43(5): 1675-82.
[http://dx.doi.org/10.3892/ijo.2013.2072] [PMID: 23969487]
[55]
Zhao G, Han X, Cheng W, et al. Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. Oncol Rep 2017; 37(4): 2277-85.
[http://dx.doi.org/10.3892/or.2017.5450] [PMID: 28260058]
[56]
Shukla S, Kanwal R, Shankar E, et al. Apigenin blocks IKKα activation and suppresses prostate cancer progression. Oncotarget 2015; 6(31): 31216-32.
[http://dx.doi.org/10.18632/oncotarget.5157] [PMID: 26435478]
[57]
Zhang H, Liu G, Zeng X, et al. Fabrication of genistein-loaded biodegradable TPGS-b-PCL nanoparticles for improved therapeutic effects in cervical cancer cells. Int J Nanomed 2015; 2461-73.
[58]
Huang S, Yu M, Shi N, et al. Apigenin and Abivertinib, a novel BTK inhibitor synergize to inhibit diffuse large B-cell lymphoma in vivo and vitro. J Cancer 2020; 11(8): 2123-32.
[http://dx.doi.org/10.7150/jca.34981] [PMID: 32127939]
[59]
Wan Y, Fei X, Wang Z, et al. Retracted - miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. Tumour Biol 2017; 39(4)
[http://dx.doi.org/10.1177/1010428317695526] [PMID: 28381178]
[60]
Chen J, Xu B, Sun J, Jiang X, Bai W. Anthocyanin supplement as a dietary strategy in cancer prevention and management: A comprehensive review. Crit Rev Food Sci Nutr 2022; 62(26): 7242-54.
[http://dx.doi.org/10.1080/10408398.2021.1913092] [PMID: 33872094]
[61]
Kausar H, Jeyabalan J, Aqil F, et al. Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett 2012; 325(1): 54-62.
[http://dx.doi.org/10.1016/j.canlet.2012.05.029] [PMID: 22659736]
[62]
Lage NN, Layosa MAA, Arbizu S, et al. Dark sweet cherry (Prunus avium) phenolics enriched in anthocyanins exhibit enhanced activity against the most aggressive breast cancer subtypes without toxicity to normal breast cells. J Funct Foods 2020; 64: 103710.
[http://dx.doi.org/10.1016/j.jff.2019.103710]
[63]
Eskra JN, Schlicht MJ, Bosland MC. Effects of black raspberries and their ellagic acid and anthocyanin constituents on taxane chemotherapy of castration-resistant prostate cancer cells. Sci Rep 2019; 9(1): 4367.
[http://dx.doi.org/10.1038/s41598-019-39589-1] [PMID: 30867440]
[64]
Lu JN, Lee WS, Nagappan A, et al. Anthocyanins from the fruit of vitiscoignetiaepulliat potentiate the cisplatin activity by inhibiting PI3K/Akt signaling pathways in human gastric cancer cells. J Cancer Prev 2015; 20(1): 50-6.
[http://dx.doi.org/10.15430/JCP.2015.20.1.50] [PMID: 25853103]
[65]
Vuolo MM, Batista ÂG, Biasoto ACT, Correa LC, Júnior MRM, Liu RH. Red-jambo peel extract shows antiproliferative activity against HepG2 human hepatoma cells. Food Res Int 2019; 124: 93-100.
[http://dx.doi.org/10.1016/j.foodres.2018.08.040] [PMID: 31466655]
[66]
Chen HH, Chen SP, Zheng QL, et al. Genistein promotes proliferation of human cervical cancer cells through estrogen receptor-mediated PI3K/Akt-NF-κB Pathway. J Cancer 2018; 9(2): 288-95.
[http://dx.doi.org/10.7150/jca.20499] [PMID: 29344275]
[67]
López de las Hazas MC, Mosele JI, Macià A, Ludwig IA, Motilva MJ. Exploring the colonic metabolism of grape and strawberry anthocyanins and their in vitro apoptotic effects in HT-29 colon cancer cells. J Agric Food Chem 2017; 65(31): 6477-87.
[http://dx.doi.org/10.1021/acs.jafc.6b04096] [PMID: 27790915]
[68]
Guo J, Wang Q, Zhang Y, et al. Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer. Pharmacol Res 2019; 147: 104387.
[http://dx.doi.org/10.1016/j.phrs.2019.104387] [PMID: 31408695]
[69]
Park HJ, Jeon YK, You DH, Nam MJ. Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. Food Chem Toxicol 2013; 60: 542-9.
[http://dx.doi.org/10.1016/j.fct.2013.08.022] [PMID: 23959101]
[70]
Moradzadeh M, Hosseini A, Erfanian S, Rezaei H. Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase. Pharmacol Rep 2017; 69(5): 924-8.
[http://dx.doi.org/10.1016/j.pharep.2017.04.008] [PMID: 28646740]
[71]
Bao L, Liu F, Guo H, et al. Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway. Tumour Biol 2016; 37(8): 11365-74.
[http://dx.doi.org/10.1007/s13277-016-5013-2] [PMID: 26960693]
[72]
Kwak TW, Park SB, Kim HJ, Jeong YI, Kang DH. Anticancer activities of epigallocatechin-3-gallate against cholangiocarcinoma cells. OncoTargets Ther 2016; 10: 137-44.
[http://dx.doi.org/10.2147/OTT.S112364] [PMID: 28053547]
[73]
Oliveira MR, Nabavi SF, Daglia M, Rastrelli L, Nabavi SM. Epigallocatechin gallate and mitochondria-A story of life and death. Pharmacol Res 2016; 104: 70-85.
[http://dx.doi.org/10.1016/j.phrs.2015.12.027] [PMID: 26731017]
[74]
Abd Razak N, Yeap SK, Alitheen NB, et al. Eupatorin suppressed tumor progression and enhanced immunity in a 4T1 murine breast cancer model. Integr Cancer Ther 2020; 19.
[http://dx.doi.org/10.1177/1534735420935625] [PMID: 32830560]
[75]
Namazi Sarvestani N, Sepehri H, Delphi L, Moridi Farimani M. Eupatorin and salvigenin potentiate doxorubicin-induced apoptosis and cell cycle arrest in HT-29 and SW948 human colon cancer cells. Asian Pac J Cancer Prev 2018; 19(1): 131-9.
[PMID: 29373904]
[76]
Sharma E, Attri DC, Sati P, et al. Recent updates on anticancer mechanisms of polyphenols. Front Cell Dev Biol 2022; 10: 1005910.
[http://dx.doi.org/10.3389/fcell.2022.1005910] [PMID: 36247004]
[77]
Kaushik S, Shyam H, Agarwal S, et al. Genistein potentiates centchroman induced antineoplasticity in breast cancer via PI3K/Akt deactivation and ROS dependent induction of apoptosis. Life Sci 2019; 239: 117073.
[http://dx.doi.org/10.1016/j.lfs.2019.117073] [PMID: 31751581]
[78]
Solomon LA, Ali S, Banerjee S, Munkarah AR, Morris RT, Sarkar FH. Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB. J Ovarian Res 2008; 1(1): 9.
[http://dx.doi.org/10.1186/1757-2215-1-9] [PMID: 19025644]
[79]
Shafiee G, Saidijam M, Tavilani H, Ghasemkhani N, Khodadadi I. Genistein induces apoptosis and inhibits proliferation of ht29 colon cancer cells. Int J Mol Cell Med 2016; 5(3): 178-91.
[PMID: 27942504]
[80]
Qin J, Teng J, Zhu Z, Chen J, Huang WJ. Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells. Pharm Biol 2016; 54(1): 74-9.
[http://dx.doi.org/10.3109/13880209.2015.1014921] [PMID: 25880142]
[81]
Sundaram MK, Unni S, Somvanshi P, et al. Genistein modulates signaling pathways and targets several epigenetic markers in hela cells. Genes 2019; 10(12): 955.
[http://dx.doi.org/10.3390/genes10120955] [PMID: 31766427]
[82]
Palit S, Kar S, Sharma G, Das PK. Hesperetin induces apoptosis in breast carcinoma by triggering accumulation of ROS and activation of ASK1/JNK pathway. J Cell Physiol 2015; 230(8): 1729-39.
[http://dx.doi.org/10.1002/jcp.24818] [PMID: 25204891]
[83]
Pandey P, Sayyed U, Tiwari RK, Siddiqui MH, Pathak N, Bajpai P. Hesperidin induces ROS-mediated apoptosis along with cell cycle arrest at G2/M phase in human gall bladder carcinoma. Nutr Cancer 2019; 71(4): 676-87.
[http://dx.doi.org/10.1080/01635581.2018.1508732] [PMID: 30265812]
[84]
Wu B, Liang Y, Tan Y, et al. Genistein-loaded nanoparticles of star-shaped diblock copolymer mannitol-core PLGA–TPGS for the treatment of liver cancer. Mater Sci Eng C 2016; 59: 792-800.
[http://dx.doi.org/10.1016/j.msec.2015.10.087] [PMID: 26652434]
[85]
Choi JB, Kim JH, Lee H, Pak JN, Shim BS, Kim SH. Reactive oxygen species and p53 mediated activation of p38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells. J Agric Food Chem 2018; 66(38): 9960-7.
[http://dx.doi.org/10.1021/acs.jafc.8b02656] [PMID: 30211553]
[86]
Seydi E, Salimi A, Rasekh HR, Mohsenifar Z, Pourahmad J. Selective cytotoxicity of luteolin and kaempferol on cancerous hepatocytes obtained from rat model of hepatocellular carcinoma: involvement of ROS-mediated mitochondrial targeting. Nutr Cancer 2018; 70(4): 594-604.
[87]
Yao Y, Rao C, Zheng G, Wang S. Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR 384/pleiotrophin axis. Oncol Rep 2019; 42(1): 131-41.
[http://dx.doi.org/10.3892/or.2021.8082] [PMID: 31059061]
[88]
Meng G, Chai K, Li X, Zhu Y, Huang W. Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway. Chem Biol Interact 2016; 257: 26-34.
[http://dx.doi.org/10.1016/j.cbi.2016.07.028] [PMID: 27474067]
[89]
Tsai PH, Cheng CH, Lin CY, et al. Dietary flavonoids luteolin and quercetin suppressed cancer stem cell properties and metastatic potential of isolated prostate cancer cells. Anticancer Res 2016; 36(12): 6367-80.
[http://dx.doi.org/10.21873/anticanres.11234] [PMID: 27919958]
[90]
Pu Y, Zhang T, Wang J, et al. Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs. J Cancer 2018; 9(20): 3669-75.
[http://dx.doi.org/10.7150/jca.27183] [PMID: 30405835]
[91]
Im E, Yeo C, Lee EO. Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells. Life Sci 2018; 209: 259-66.
[http://dx.doi.org/10.1016/j.lfs.2018.08.025] [PMID: 30107166]
[92]
Çetinkaya M, Baran Y. Therapeutic potential of luteolin on cancer. Vaccines 2023; 11(3): 554.
[http://dx.doi.org/10.3390/vaccines11030554] [PMID: 36992138]
[93]
Lee HS, Park BS, Kang HM, Kim JH, Shin SH, Kim IR. Role of luteolin-induced apoptosis and autophagy in human glioblastoma cell lines. Medicina 2021; 57(9): 879.
[http://dx.doi.org/10.3390/medicina57090879] [PMID: 34577802]
[94]
Noori S, Rezaei Tavirani M, Deravi N, Mahboobi Rabbani MI, Zarghi A. Naringenin enhances the anti-cancer effect of cyclophosphamide against MDA-MB-231 breast cancer cells via targeting the stat3 signaling pathway. Iran J Pharm Res 2020; 19(3): 122-33.
[http://dx.doi.org/10.22037/ijpr.2020.113103.14112] [PMID: 33680016]
[95]
Zhang H, Zhong X, Zhang X, Shang D, Zhou Y, Zhang C. Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. Exp Ther Med 2016; 11(2): 669-73.
[http://dx.doi.org/10.3892/etm.2015.2912] [PMID: 26893664]
[96]
Park S, Lim W, Bazer FW, Song G. Naringenin suppresses growth of human placental choriocarcinoma via reactive oxygen species-mediated P38 and JNK MAPK pathways. Phytomedicine 2018; 50: 238-46.
[http://dx.doi.org/10.1016/j.phymed.2017.08.026] [PMID: 30466984]
[97]
Ahamad MS, Siddiqui S, Jafri A, Ahmad S, Afzal M, Arshad M. Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest. PLoS One 2014; 9(10): e110003.
[http://dx.doi.org/10.1371/journal.pone.0110003] [PMID: 25330158]
[98]
Lim W, Park S, Bazer FW, Song G. Naringenin‐induced apoptotic cell death in prostate cancer cells is mediated via the PI3K/AKT and MAPK signaling pathways. J Cell Biochem 2017; 118(5): 1118-31.
[http://dx.doi.org/10.1002/jcb.25729] [PMID: 27606834]
[99]
Jeon JS, Kwon S, Ban K, et al. Regulation of the intracellular ROS level is critical for the antiproliferative effect of quercetin in the hepatocellular carcinoma cell line HepG2. Nutr Cancer 2019; 71(5): 861-9.
[http://dx.doi.org/10.1080/01635581.2018.1559929] [PMID: 30661409]
[100]
Shang HS, Lu HF, Lee CH, et al. Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol 2018; 33(11): 1168-81.
[http://dx.doi.org/10.1002/tox.22623] [PMID: 30152185]
[101]
Sun S, Gong F, Liu P, Miao Q. Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. Gene 2018; 664: 50-7.
[http://dx.doi.org/10.1016/j.gene.2018.04.045] [PMID: 29678660]
[102]
Song Y, Han M, Zhang X. Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating toll-like receptor 4/Nuclear Factor-kappa B pathway. Pharmacogn Mag 2016; 12(46) (Suppl. 2): 237.
[http://dx.doi.org/10.4103/0973-1296.182154] [PMID: 27279714]
[103]
Chen SF, Nieh S, Jao SW, et al. Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells. PLoS One 2012; 7(11): e49275.
[http://dx.doi.org/10.1371/journal.pone.0049275] [PMID: 23152886]
[104]
Zhao S, Jiang Y, Zhao J, et al. Quercetin‐3‐methyl ether inhibits esophageal carcinogenesis by targeting the AKT/mTOR/p70S6K and MAPK pathways. Mol Carcinog 2018; 57(11): 1540-52.
[http://dx.doi.org/10.1002/mc.22876] [PMID: 30035335]
[105]
Liu H, Zhou M. Antitumor effect of quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways. BMC Complement Altern Med 2017; 17(1): 531.
[http://dx.doi.org/10.1186/s12906-017-2023-6] [PMID: 29237430]
[106]
Kim SH, Yoo ES, Woo JS, et al. Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK/P38 MAPK signaling activation. Eur J Pharmacol 2019; 860: 172568.
[http://dx.doi.org/10.1016/j.ejphar.2019.172568] [PMID: 31348906]
[107]
Ryu S, Park S, Lim W, Song G. Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction. J Cell Biochem 2019; 120(10): 17449-58.
[http://dx.doi.org/10.1002/jcb.29009] [PMID: 31131468]
[108]
Yuan Z, Long C, Junming T, Qihuan L, Youshun Z, Chan Z. Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Mol Biol Rep 2012; 39(7): 7785-93.
[http://dx.doi.org/10.1007/s11033-012-1621-0] [PMID: 22555976]
[109]
Liu Y, Tang ZG, Lin Y, et al. Effects of quercetin on proliferation and migration of human glioblastoma U251 cells. Biomed Pharmacother 2017; 92: 33-8.
[http://dx.doi.org/10.1016/j.biopha.2017.05.044] [PMID: 28528183]
[110]
Hasani NA, Amin IM, Kamaludin R, Rosdyd NM, Ibahim MJ, Kadir SH. P53 and cyclin B1 mediate apoptotic effects of apigenin and rutin in ERα+-breast cancer MCF-7 cells. J Teknol 2018; 80: 133-40.
[111]
Park MH, Kim S, Song Y, et al. Rutin induces autophagy in cancer cells. Int J Oral Biol 2016; 41(1): 45-51.
[http://dx.doi.org/10.11620/IJOB.2016.41.1.045]
[112]
Nasri Nasrabadi P, Zareian S, Nayeri Z, et al. A detailed image of rutin underlying intracellular signaling pathways in human SW480 colorectal cancer cells based on miRNAs‐lncRNAs‐mRNAs‐TFs interactions. J Cell Physiol 2019; 234(9): 15570-80.
[http://dx.doi.org/10.1002/jcp.28204] [PMID: 30697726]
[113]
Dedoussis G, Kaliora A, Andrikopoulos N. Effect of phenols on natural killer (NK) cell-mediated death in the K562 human leukemic cell line. Cell Biol Int 2005; 29(11): 884-9.
[http://dx.doi.org/10.1016/j.cellbi.2005.07.006] [PMID: 16198604]
[114]
Ikeda NEA, Novak EM, Maria DA, Velosa AS, Pereira RMS. Synthesis, characterization and biological evaluation of Rutin–zinc(II) flavonoid -metal complex. Chem Biol Interact 2015; 239: 184-91.
[http://dx.doi.org/10.1016/j.cbi.2015.06.011] [PMID: 26091902]
[115]
Labh AK, Priya VV, Gayathri R. Cytotoxic action of rutin isolated from Morindacitrifolia against hepatic carcinoma cell lines. Drug Invent Today 2019; 12(9)
[116]
Li Q, Ren L, Zhang Y, et al. P38 signal transduction pathway has more cofactors on apoptosis of SGC-7901 gastric cancer cells induced by combination of rutin and oxaliplatin. Biomed Res Int 2019; 2019.
[117]
Mohana S, Ganesan M, Rajendra Prasad N, Ananthakrishnan D, Velmurugan D. RETRACTED ARTICLE: Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines. BMC Cancer 2018; 18(1): 1168.
[http://dx.doi.org/10.1186/s12885-018-5103-1] [PMID: 30477461]
[118]
Nouri Z, Fakhri S, Nouri K, Wallace CE, Farzaei MH, Bishayee A. Targeting multiple signaling pathways in cancer: The rutin therapeutic approach. Cancers 2020; 12(8): 2276.
[http://dx.doi.org/10.3390/cancers12082276] [PMID: 32823876]
[119]
Yan X, Hao Y, Chen S, et al. Rutin induces apoptosis via P53 up-regulation in human glioma CHME cells. Transl Cancer Res 2019; 8(5): 2005-13.
[http://dx.doi.org/10.21037/tcr.2019.09.07] [PMID: 35116949]
[120]
Li XH, Liu ZY, Gu Y, Lv Z, Chen Y, Gao HC. Expression of NF-kappaB and p38 under intervention of rutin in lung cancer therapy. Biomed Res 2017; 28(5): 2344-7.
[121]
Nambiar D, Prajapati V, Agarwal R, Singh RP. In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells. Cancer Lett 2013; 334(1): 109-17.
[http://dx.doi.org/10.1016/j.canlet.2012.09.004] [PMID: 23022268]
[122]
Komal R, Sushil K, Deepanshi D, Rajesh A. Silibinin and colorectal cancer chemoprevention: A comprehensive review on mechanisms and efficacy. J Biomed Res 2016; 30(6): 452-65.
[http://dx.doi.org/10.7555/JBR.30.20150111] [PMID: 27476880]
[123]
Koushki M, Khedri A, Aberomand M, Akbari Baghbani K, Mohammadzadeh G. Synergistic anti-cancer effects of silibinin-etoposide combination against human breast carcinoma MCF-7 and MDA-MB-231 cell lines. Iran J Basic Med Sci 2021; 24(9): 1211-9.
[PMID: 35083008]
[124]
Bai ZL, Tay V, Guo SZ, Ren J, Shu MG. Silibinin-induced human glioblastoma cell apoptosis concomitant with autophagy through simultaneous inhibition of mTOR and YAP Biomed Res Int 2018; 2018.
[http://dx.doi.org/10.1155/2018/6165192]
[125]
Koltai T, Fliegel L. Role of silymarin in cancer treatment: Facts, hypotheses, and questions. J Evid Based Integr Med 2022; 27: 2515690X211068826.
[126]
Eo HJ, Park GH, Jeong JB. Inhibition of Wnt signaling by silymarin in human colorectal cancer cells. Biomol Ther 2016; 24(4): 380-6.
[http://dx.doi.org/10.4062/biomolther.2015.154] [PMID: 27068260]
[127]
Shariatzadeh SM, Hamta A, Soleimani M, Fallah Huseini H, Samavat S. The cytotoxic effects of silymarin on the 4T1 cell line derived from BALB/c mice mammary tumors. Faslnamah-i Giyahan-i Daruyi 2014; 13(52): 55-65.
[128]
Yousefi M, Shadnoush M, Sohrabvand S, Khorshidian N, Mortazavian AM. Encapsulation systems for delivery of flavonoids: A. Biointerface Res Appl Chem 2021; 6: 13934-51.
[129]
Gomes D, Silvestre S, Duarte AP, et al. In silico approaches: A way to unveil novel therapeutic drugs for cervical cancer management. Pharmaceuticals 2021; 14(8): 741.
[http://dx.doi.org/10.3390/ph14080741] [PMID: 34451838]
[130]
Liang Y, Zhong Q, Ma R, et al. Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma Ishikawa cells in vitro and in vivo. Food Sci Hum Wellness 2023; 12(6): 2242-51.
[http://dx.doi.org/10.1016/j.fshw.2023.03.044]
[131]
Chen YH, Wu JX, Yang SF, Hsiao YH. Synergistic combination of luteolin and asiatic acid on cervical cancer in vitro and in vivo. Cancers 2023; 15(2): 548.
[http://dx.doi.org/10.3390/cancers15020548] [PMID: 36672499]
[132]
Pan F, Liu Y, Liu J, Wang E. Stability of blueberry anthocyanin, anthocyanidin and pyranoanthocyanidin pigments and their inhibitory effects and mechanisms in human cervical cancer HeLa cells. RSC Advances 2019; 9(19): 10842-53.
[http://dx.doi.org/10.1039/C9RA01772K] [PMID: 35515294]
[133]
Hua F, Li CH, Chen XG, Liu XP. Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest and inhibiting the Raf/MEK/ERK cascade Retraction. Int J Mol Med 2018; 41(6): 3485-92.
[134]
Ollberding NJ, Lim U, Wilkens LR, et al. Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study. J Natl Cancer Inst 2012; 104(1): 67-76.
[http://dx.doi.org/10.1093/jnci/djr475] [PMID: 22158125]
[135]
Wang J, Man GCW, Chan TH, Kwong J, Wang CC. A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer. Cancer Lett 2018; 412: 10-20.
[http://dx.doi.org/10.1016/j.canlet.2017.09.054] [PMID: 29024813]
[136]
Yan C, Yang J, Shen L, Chen X. Inhibitory effect of Epigallocatechin gallate on ovarian cancer cell proliferation associated with aquaporin 5 expression. Arch Gynecol Obstet 2012; 285(2): 459-67.
[http://dx.doi.org/10.1007/s00404-011-1942-6] [PMID: 21698451]
[137]
Lee K, Hyun Lee D, Jung YJ, Shin SY, Lee YH. The natural flavone eupatorin induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells. Applied Biological Chemistry 2016; 59(2): 193-9.
[http://dx.doi.org/10.1007/s13765-016-0160-0]
[138]
Yoriki K, Mori T, Aoyama K, et al. Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients. Sci Rep 2022; 12(1): 10303.
[http://dx.doi.org/10.1038/s41598-022-13842-6] [PMID: 35717540]
[139]
Ning Y, Feng W, Cao X, et al. RETRACTED ARTICLE: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis. J Exp Clin Cancer Res 2019; 38(1): 19.
[http://dx.doi.org/10.1186/s13046-018-1010-1] [PMID: 30646963]
[140]
Ghaemi A, Soleimanjahi H, Razeghi S, et al. Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer. Iran J Immunol 2012; 9(2): 119-27.
[PMID: 22735799]
[141]
Ren F, Zhang G, Li C, Li G, Cao Y, Sun F. Hesperidin induces mitochondria mediated intrinsic apoptosis in hpv-positive cervical cancer cells via regulation of E6/p53 expression. Available from: https://europepmc.org/article/ppr/ppr237899
[142]
Shoorei H, Banimohammad M, Kebria MM, et al. Hesperidin improves the follicular development in 3D culture of isolated preantral ovarian follicles of mice. Exp Biol Med 2019; 244(5): 352-61.
[http://dx.doi.org/10.1177/1535370219831615] [PMID: 30781997]
[143]
Cincin ZB, Kiran B, Baran Y, Cakmakoglu B. Hesperidin promotes programmed cell death by downregulation of nongenomic estrogen receptor signalling pathway in endometrial cancer cells. Biomed Pharmacother 2018; 103: 336-45.
[http://dx.doi.org/10.1016/j.biopha.2018.04.020] [PMID: 29665555]
[144]
Imran M, Rauf A, Abu-Izneid T, et al. Luteolin, a flavonoid, as an anticancer agent: A review. Biomed Pharmacother 2019; 112: 108612.
[http://dx.doi.org/10.1016/j.biopha.2019.108612] [PMID: 30798142]
[145]
Kashafi E, Moradzadeh M, Mohamadkhani A, Erfanian S. Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways. Biomed Pharmacother 2017; 89: 573-7.
[http://dx.doi.org/10.1016/j.biopha.2017.02.061] [PMID: 28258039]
[146]
Woo JH, Jang DS, Choi JH. Luteolin promotes apoptosis of endometriotic cells and inhibits the alternative activation of endometriosis-associated macrophages. Biomol Ther 2021; 29(6): 678-84.
[http://dx.doi.org/10.4062/biomolther.2021.045] [PMID: 34011694]
[147]
Cheng H, Jiang X, Zhang Q, et al. Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway. Exp Ther Med 2020; 19(6): 3798-804.
[http://dx.doi.org/10.3892/etm.2020.8649] [PMID: 32346444]
[148]
Aichinger G, Beisl J, Marko D. The hop polyphenols xanthohumol and 8-prenyl-naringenin antagonize the estrogenic effects of fusarium mycotoxins in human endometrial cancer cells. Front Nutr 2018; 5: 85.
[http://dx.doi.org/10.3389/fnut.2018.00085] [PMID: 30283786]
[149]
Zhu H, Gao J, Wang L, Qian KJ, Cai LP. In vitro study on reversal of ovarian cancer cell resistance to cisplatin by naringin via the nuclear factor-κB signaling pathway. Exp Ther Med 2018; 15(3): 2643-8.
[http://dx.doi.org/10.3892/etm.2018.5695] [PMID: 29456667]
[150]
Farhan M, Rizvi A, Aatif M, Ahmad A. Current understanding of flavonoids in cancer therapy and prevention. Metabolites 2023; 13(4): 481.
[http://dx.doi.org/10.3390/metabo13040481] [PMID: 37110140]
[151]
Murata M, Komatsu S, Miyamoto E, et al. Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer. Biosci Microbiota Food Health 2023; 42(1): 87-93.
[http://dx.doi.org/10.12938/bmfh.2022-056] [PMID: 36660602]
[152]
Lins TLBG, Gouveia BB, Barberino RS, et al. Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model. Reprod Toxicol 2020; 98: 209-17.
[http://dx.doi.org/10.1016/j.reprotox.2020.10.001] [PMID: 33031932]
[153]
Deepika MS, Thangam R, Sheena TS, et al. A novel rutin-fucoidan complex based phytotherapy for cervical cancer through achieving enhanced bioavailability and cancer cell apoptosis. Biomed Pharmacother 2019; 109: 1181-95.
[http://dx.doi.org/10.1016/j.biopha.2018.10.178] [PMID: 30551368]
[154]
Koushki M, Farrokhi Yekta R, Amiri-Dashatan N. Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid. J Funct Foods 2023; 104: 105502.
[http://dx.doi.org/10.1016/j.jff.2023.105502]
[155]
You Y, He Q, Lu H, et al. Silibinin induces G2/M cell cycle arrest by activating Drp1-dependent mitochondrial fission in cervical cancer. Front Pharmacol 2020; 11: 271.
[http://dx.doi.org/10.3389/fphar.2020.00271] [PMID: 32226384]
[156]
Fan L, Ma Y, Liu Y, Zheng D, Huang G. Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells. Eur J Pharmacol 2014; 743: 79-88.
[http://dx.doi.org/10.1016/j.ejphar.2014.09.019] [PMID: 25242120]
[157]
Grosso G, Buscemi S, Galvano F, et al. Mediterranean diet and cancer: Epidemiological evidence and mechanism of selected aspects. BMC Surg 2013; 13(S2): S14.
[http://dx.doi.org/10.1186/1471-2482-13-S2-S14] [PMID: 24267672]
[158]
Cassidy A, Huang T, Rice MS, Rimm EB, Tworoger SS. Intake of dietary flavonoids and risk of epithelial ovarian cancer. Am J Clin Nutr 2014; 100(5): 1344-51.
[http://dx.doi.org/10.3945/ajcn.114.088708] [PMID: 25332332]
[159]
Grosso G, Godos J, Lamuela-Raventos R, et al. A comprehensive meta‐analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations. Mol Nutr Food Res 2017; 61(4): 1600930.
[http://dx.doi.org/10.1002/mnfr.201600930] [PMID: 27943649]
[160]
Tavsan Z, Kayali HA. Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion. Biomed Pharmacother 2019; 116: 109004.
[http://dx.doi.org/10.1016/j.biopha.2019.109004] [PMID: 31128404]
[161]
Nielsen AJ, McNulty J. Polyphenolic natural products and natural product–inspired steroidal mimics as aromatase inhibitors. Med Res Rev 2019; 39(4): 1274-93.
[http://dx.doi.org/10.1002/med.21536] [PMID: 30171625]
[162]
Budhathoki S, Iwasaki M, Sawada N, et al. Soy food and isoflavone intake and endometrial cancer risk: the J apan public health center‐based prospective study. BJOG 2015; 122(3): 304-11.
[http://dx.doi.org/10.1111/1471-0528.12853] [PMID: 24941880]
[163]
Pal MK, Jaiswar SP, Dwivedi A, et al. Synergistic effect of graphene oxide coated nanotised apigenin with paclitaxel (GO-NA/PTX): A ROS dependent mitochondrial-mediated apoptosis in ovarian cancer. Anticancer Agents Med Chem 2017; 17(12): 1721-32.
[PMID: 28443516]
[164]
Tan M, Zhu J, Pan Y, et al. Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. Bioinorg Chem Appl 2009; 2009.
[165]
Talib WH, Abuawad A, Thiab S, Alshweiat A, Mahmod AI. Flavonoid-based nanomedicines to target tumor microenvironment. OpenNano 2022; 8: 100081.
[http://dx.doi.org/10.1016/j.onano.2022.100081]
[166]
Bindhya KP, Uma Maheswari P, Meera Sheriffa Begum KM. Milk protein inspired multifunctional magnetic carrier targeting progesterone receptors: Improved anticancer potential of soybean-derived genistein against breast and ovarian cancers. Mater Chem Phys 2021; 272: 125055.
[http://dx.doi.org/10.1016/j.matchemphys.2021.125055]
[167]
Kelte Filho I, Machado CS, Diedrich C, et al. Optimized chitosan-coated gliadin nanoparticles improved the hesperidin cytotoxicity over tumor cells. Braz Arch Biol Technol 2021; 64(spe): e21200795.
[http://dx.doi.org/10.1590/1678-4324-75years-2021200795]
[168]
K Purushothaman B. P UM, K M MSB. Magnetic casein-CaFe2O4 nanohybrid carrier conjugated with progesterone for enhanced cytotoxicity of citrus peel derived hesperidin drug towards breast and ovarian cancer. Int J Biol Macromol 2020; 151: 293-304.
[http://dx.doi.org/10.1016/j.ijbiomac.2020.02.172] [PMID: 32084471]
[169]
Zhang X, Pan Q, Hao L, et al. Preparation of magnetic fluorescent dual-drug nanocomposites for codelivery of kaempferol and paclitaxel. Journal of Wuhan University of Technology Mater Sci Ed 2018; 33(1): 256-62.
[http://dx.doi.org/10.1007/s11595-018-1814-z]
[170]
Luo H, Jiang B, Li B, Li Z, Jiang BH, Chen YC. Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int J Nanomedicine 2012; 7: 3951-9.
[PMID: 22866004]
[171]
Akal ZÜ, Alpsoy L, Baykal A. Biomedical applications of SPION@APTES@PEG-folic acid@carboxylated quercetin nanodrug on various cancer cells. Appl Surf Sci 2016; 378: 572-81.
[http://dx.doi.org/10.1016/j.apsusc.2016.03.217]
[172]
Alpsoy L, Baykal A, Kurtan U, Ülker Z. Synthesis and characterization of carboxylated luteolin (CL)-functionalized SPION. J Supercond Nov Magn 2017; 30(10): 2797-804.
[http://dx.doi.org/10.1007/s10948-017-4056-y]
[173]
Fuster MG, Carissimi G, Montalbán MG, Víllora G. Improving anticancer therapy with naringenin-loaded silk fibroin nanoparticles. Nanomaterials 2020; 10(4): 718.
[http://dx.doi.org/10.3390/nano10040718] [PMID: 32290154]
[174]
Ferreira M, Gomes D, Neto M, Passarinha LA, Costa D, Sousa Â. Development and characterization of quercetin-loaded delivery systems for increasing its bioavailability in cervical cancer cells. Pharmaceutics 2023; 15(3): 936.
[http://dx.doi.org/10.3390/pharmaceutics15030936] [PMID: 36986797]
[175]
Long Q, Xie Y, Huang Y, et al. Induction of apoptosis and inhibition of angiogenesis by PEGylated liposomal quercetin in both cisplatin-sensitive and cisplatin-resistant ovarian cancers. J Biomed Nanotechnol 2013; 9(6): 965-75.
[http://dx.doi.org/10.1166/jbn.2013.1596] [PMID: 23858960]
[176]
Ferreira M, Costa D, Sousa Â. Flavonoids-based delivery systems towards cancer therapies. Bioengineering 2022; 9(5): 197.
[http://dx.doi.org/10.3390/bioengineering9050197] [PMID: 35621475]
[177]
Gaikwad SS, Morade YY, Kothule AM, Kshirsagar SJ, Laddha UD, Salunkhe KS. Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook. Heliyon 2023; 9(6): e16561.
[http://dx.doi.org/10.1016/j.heliyon.2023.e16561] [PMID: 37260890]
[178]
Katopodi A, Detsi A. Solid lipid nanoparticles and nanostructured lipid carriers of natural products as promising systems for their bioactivity enhancement: The case of essential oils and flavonoids. Colloids Surf A Physicochem Eng Asp 2021; 630: 127529.
[http://dx.doi.org/10.1016/j.colsurfa.2021.127529]
[179]
Mashhadi Malekzadeh A, Ramazani A, Tabatabaei Rezaei SJ, Niknejad H. Design and construction of multifunctional hyperbranched polymers coated magnetite nanoparticles for both targeting magnetic resonance imaging and cancer therapy. J Colloid Interface Sci 2017; 490: 64-73.
[http://dx.doi.org/10.1016/j.jcis.2016.11.014] [PMID: 27870961]
[180]
Yamina AM, Fizir M, Itatahine A, He H, Dramou P. Preparation of multifunctional PEG-graft-halloysite nanotubes for controlled drug release, tumor cell targeting, and bio-imaging. Colloids Surf B Biointerfaces 2018; 170: 322-9.
[http://dx.doi.org/10.1016/j.colsurfb.2018.06.042] [PMID: 29936385]
[181]
Van Thoai D, Nguyen DT, Dang LH, et al. Lipophilic effect of various pluronic-grafted gelatin copolymers on the quercetin delivery efficiency in these self-assembly nanogels. J Polym Res 2020; 27(12): 369.
[http://dx.doi.org/10.1007/s10965-020-02216-z]
[182]
Rajawat S, Koutu V, Saha S, Malik MM. Biopolymers as silver nanoparticle carriers for targeted drug delivery. Mater Today Proc 2023; 6.
[http://dx.doi.org/10.1016/j.matpr.2022.12.226]
[183]
Caballero S, Li YO, McClements DJ, Davidov-Pardo G. Encapsulation and delivery of bioactive citrus pomace polyphenols: A review. Crit Rev Food Sci Nutr 2021; 1-17.
[PMID: 33983085]
[184]
Krauland A, Alonso M. Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system. Int J Pharm 2007; 340(1-2): 134-42.
[http://dx.doi.org/10.1016/j.ijpharm.2007.03.005] [PMID: 17459620]
[185]
Zhu P, Chen L, Zhao Y, et al. A novel host-guest complex based on biotin functionalized polyamine-β-cyclodextrin for tumor targeted delivery of luteolin. J Mol Struct 2021; 1237: 130339.
[http://dx.doi.org/10.1016/j.molstruc.2021.130339]
[186]
Khan H, Ullah H, Martorell M, et al. Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects. Semin Cancer Biol 2019; 57: 72-8.
[PMID: 31374244]
[187]
Wu D, Zhang J, Wang J, Li J, Liao F, Dong W. Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species. Tumour Biol 2016; 37(3): 3451-9.
[http://dx.doi.org/10.1007/s13277-015-4176-6] [PMID: 26449828]
[188]
Tu LY, Bai HH, Cai JY, Deng SP. The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: From macro to nano. Scanning 2016; 38(6): 644-53.
[http://dx.doi.org/10.1002/sca.21312] [PMID: 26890985]

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