Title:Anti-cancer Potential of Phytoflavonoidal Drugs against Gynecological
Cancer
Volume: 20
Author(s): Kavita Sangwan*Parveen Kumar Goyal
Affiliation:
- Department of Pharmacy, Panipat Institute of Engineering and Technology (PIET), Samalkha, Panipat-132102,
Haryana, India
Keywords:
Phytoflavonoids, Gyenocological cancer, Drug delivery system, Cervical cancer, Ovarian cancer, Endometrial cancer.
Abstract: Background: Flavonoids, one of the major bioactive constituents of herbal drugs, have
been scientifically reported to possess diverse therapeutic potentials such as anticancer, immunomodulatory, neuroprotective, cardioprotective, antioxidant, etc. This manuscript enlightens the anticancer
potential of traditional herbal flavonoids in gynecological cancer i.e., is one of the major life-threats
in women.
Objective: This manuscript is aimed at an insightful compilation of scientific substantiations of herbal
flavonoids in gynecological cancer along with targeted drug delivery systems for the same.
Materials and Methods: The contents and data represented in the article have been reviewed using
institutional libraries and online database resources (available in the public domain) such as PubMed,
Science-Direct, Web of Science, American Association of Pharmaceutical Scientists, Google Scholar,
Hinari, SciFinder, Research Gate, etc.
Results: Flavonoids are natural compounds and have potential against cervical, ovarian, and endometrial cancer. In-vitro and in-vivo experiments have demonstrated the significant potential of flavonoids in gynecological cancer, especially cervical, ovarian, and endometrial cancer. It was reported
from in-vitro experimentations that targeted drug delivery system improves the anticancer effect of
flavonoids.
Conclusion: Phytoflavonoids have the potential to prevent gynecological cancer by induction of
apoptosis cell cycle arrest and reactive oxygen species generation. Further studies on the drug delivery system of flavonoids are warranted.
