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Drug Delivery Letters

Editor-in-Chief

ISSN (Print): 2210-3031
ISSN (Online): 2210-304X

Review Article

Current Drug Delivery Strategies to Design Orally Dissolving Formulations to Target Tuberculosis: A Futuristic Review

Author(s): Pinky Chowrasia, Mohini Singh, Bani Kumar Jana, Pankaj Lochan Bora, Ranjit Kumar Mahato, Rikynjai Kharbithai, Niva Rani Gogoi, Tumpa Sarkar, Paulami Pal and Bhaskar Mazumder*

Volume 14, Issue 2, 2024

Published on: 01 February, 2024

Page: [109 - 134] Pages: 26

DOI: 10.2174/0122103031267044231031044456

Price: $65

Abstract

All the standard anti-tubercular drugs, well established as standard therapy, are preferentially available in formulations compliant with the young adult population. However, their use in the paediatric and geriatric populations is confronted with issues, such as a high likelihood of incorrect dose administration due to practices like dosage form fracture and splitting. This may lead to drug resistance due to misuse and in-accurate dosage administration, the most dreaded and difficult-to-treat stage of tuberculosis.

Poor patient compliance and adherence are major issues with the conventional line of therapy. This burden may be more significant in resource-constrained settings, necessitating the creation of simple formulations that are both geriatric and child-friendly. An extensive literature survey has been conducted in this study using databases of Google Scholar, PubMed, and Research Gate, with a focus on specific research works on oro-dispersible films, tablets, and wafer technology loaded with anti-tuberculosis drugs from 2022 to 2010.

Mouth dissolving formulation technology is a very novel approach in the arena of tuberculosis therapy. This may pave the way for future researchers to develop different mouth dissolving formulations to treat both pulmonary and extra-tuberculosis. This review paper has summarized all the formulation approaches alongside the present state of the art in tuberculosis therapy using mouth dissolving formulations.

Keywords: Tuberculosis, extrapulmonary tuberculosis, mouth dissolving wafer technology, 3D printing, flash dose technology, mass extrusion, current state-of-the-art.

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Graphical Abstract
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