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Current Molecular Pharmacology

Editor-in-Chief

ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Review Article

Advancements in the Research of GEF-H1: Biological Functions and Tumor Associations

Author(s): Liqi Li, Yunyun Li* and Xiaoshu Zhou*

Volume 17, 2024

Published on: 30 January, 2024

Article ID: e18761429274883 Pages: 12

DOI: 10.2174/0118761429274883231129103220

open_access

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Abstract

Guanine nucleotide exchange factor H1 (GEF-H1) is a unique protein modulated by the GDP/GTP exchange. As a regulator of the Rho-GTPase family, GEF-H1 can be activated through a microtubule-depended mechanism and phosphorylation regulation, enabling it to perform various pivotal biological functions across multiple cellular activities. These include the regulation of Rho-GTPase, cytoskeleton formation, cellular barrier, cell cycle, mitosis, cell differentiation, and vesicle trafficking. Recent studies have revealed its crucial effect on the tumor microenvironment (TME) components, promoting tumor initiation and progress. Consequently, an in-depth exploration of GEF-H1’s biological roles and association with tumors holds promise for its potential as a valuable molecular target in tumor treatment.

Keywords: GEF-H1, Rho GTPase, Guanine nucleotide exchange factor, ARHGEF2, Cancer, RhoA.


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