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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Targeted Cancer Stem Cell Therapeutics: An Update

In Press, (this is not the final "Version of Record"). Available online 26 January, 2024
Author(s): Naurin Fatima, Mohammad Umar, Subiya Ambreen, Mohd Shaququzzaman, Mohammad Mumtaz Alam and Ruhi Ali*
Published on: 26 January, 2024

DOI: 10.2174/0115680266275014240110071351

Price: $95

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Abstract

Cancer stem cells (CSCs) have become a key player in the growth of tumors, the spread of cancer, and the resistance to therapeutic interventions. Targeting these elusive cell populations has the potential to fundamentally alter cancer treatment plans. CSCs, also known as tumor-initiating cells (TICs), are thought to play a role in both medication resistance and cancer recurrence. This is explained by their capacity to regenerate themselves and change into different kinds of cancer cells. Due to their higher expression of ATP-binding cassette (ABC) membrane transporters, enhanced epithelial to mesenchymal (EMT) characteristics, improved immune evasion, activation of survival signaling pathways, and improved DNA repair mechanisms, CSCs exhibit extraordinary resistance to therapies. This comprehensive analysis delves into advancements in the domain of Targeted Cancer Stem Cell Therapeutics, concentrating on unraveling the distinctive traits of CSCs and the therapeutic methods devised to eliminate them.

Keywords: Cancer stem cells, Self renewal, Tumor microenvironment, MicroRNAs, Epithelial-mesenchymal transition, Targeted therapy.


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