Title:Recent Developments and Future Perspectives of Purine Derivatives as a
Promising Scaffold in Drug Discovery
Volume: 24
Issue: 6
Author(s): Neha Rana*, Parul Grover and Hridayanand Singh
Affiliation:
- School of Pharmacy (SOP), Noida International University, Yamuna Expressway, Gautam Budh Nagar, 203201, India
Keywords:
Purine derivatives, Drug discovery, Structure-activity relationship, Biological targets, Pharmacological activity, Heterocyclic ring.
Abstract:
Numerous purine-containing compounds have undergone extensive investigation for
their medical efficacy across various diseases. The swift progress in purine-based medicinal chemistry
has brought to light the therapeutic capabilities of purine-derived compounds in addressing
challenging medical conditions. Defined by a heterocyclic ring comprising a pyrimidine ring
linked with an imidazole ring, purine exhibits a diverse array of therapeutic attributes. This review
systematically addresses the multifaceted potential of purine derivatives in combating various diseases,
including their roles as anticancer agents, antiviral compounds (anti-herpes, anti-HIV, and
anti-influenzae), autoimmune and anti-inflammatory agents, antihyperuricemic and anti-gout solutions,
antimicrobial agents, antitubercular compounds, anti-leishmanial agents, and anticonvulsants.
Emphasis is placed on the remarkable progress made in developing purine-based compounds,
elucidating their significant target sites.
The article provides a comprehensive exploration of developments in both natural and synthetic
purines, offering insights into their role in managing a diverse range of illnesses. Additionally, the
discussion delves into the structure-activity relationships and biological activities of the most
promising purine molecules. The intriguing capabilities revealed by these purine-based scaffolds
unequivocally position them at the forefront of drug candidate development. As such, this review
holds potential significance for researchers actively involved in synthesizing purine-based drug
candidates, providing a roadmap for the continued advancement of this promising field.