Title:Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in
Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets
Volume: 23
Issue: 10
Author(s): Seyed Hossein Shahcheraghi, Elmira Roshani Asl, Malihe Lotfi, Jamshid Ayatollahi, Seyed Hossein Khaleghinejad, Alaa A.A. Aljabali, Hamid A. Bakshi, Mohamed El-Tanani, Nitin B. Charbe, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Rohit Goyal, Altijana Hromić-Jahjefendić, Vladimir N. Uversky*, Marzieh Lotfi*Murtaza M. Tambuwala*
Affiliation:
- Department of Molecular Medicine and USF Health Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
- Abortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Lincoln Medical School, University of Lincoln, Brayford Pool Campus, Lincoln LN6 7TS, UK
Keywords:
Glioblastoma, Notch signaling, lncRNAs, miRNAs, central nervous system, brain malignancy.
Abstract: Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from
astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements
in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical
drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates
the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation.
The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes
deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1,
and Hey1, thereby promoting cellular proliferation and differentiation. Recent research has highlighted
the regulatory role of non-coding RNAs (ncRNAs) in modulating Notch signaling by targeting
critical mRNA expression at the post-transcriptional or transcriptional levels. Specifically, various
types of ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs),
have been shown to control multiple target genes and significantly contribute to the carcinogenesis
of GBM. Furthermore, these ncRNAs hold promise as prognostic and predictive markers for GBM.
This review aims to summarize the latest studies investigating the regulatory effects of ncRNAs on
the Notch signaling pathway in GBM.
