Title:Ovothiol-A Mitigates High-Fat Diet-Induced Non-alcoholic Fatty Liver
Disease in Rats
Volume: 20
Issue: 8
Author(s): Nada Hussien Arafa, Mohamed Refaat Shehata and Ayman Saber Mohamed*
Affiliation:
- Department of Zoology, Faculty of Science, Cairo University,
12613, Giza, Egypt
Keywords:
Ovothiol A, obesity, oxidative stress, sea urchin, high fat diet, rat.
Abstract:
Background: Obesity is frequently linked to multiple comorbid and chronic illnesses,
including non-alcoholic fatty liver disease, type 2 diabetes, cancer, and heart disease. Ovothiol-A
is one of the most powerful natural antioxidants found in marine invertebrates like sea urchins.
Objective: The current study aimed to investigate ovothiol-A's hypolipidemic and hypoglycemic
potential in obese rats.
Methods: All groups get a high-fat diet (HFD) for four weeks except for the control group. The
control and HFD groups received distilled water, while the Ovothiol-A groups received two doses
of Ovothiol-A (200 and 400 mg/kg orally) concurrent with HFD.
Results: Weight gain, glucose, insulin, alanine aminotransferase, aspartate aminotransferase,
gamma-glutamyl transferase, alkaline phosphatase, total cholesterol, triglycerides, low-density
lipoprotein, malondialdehyde, and nitric oxide were all decreased after oral administration of Ovo
at either the 200 or 400 mg/kg dose, while levels of high-density lipoprotein (HDL), glutathionereduced,
catalase and glutathione-S-transferase increased. Histopathological alterations were less
noticeable in the liver tissue of Ovothiol-A groups, with only a few vacuolated or pyknotic nuclei
amongst a few dispersed hepatocytes.
Conclusion: The current findings indicate that ovothiol-A protects against high-fat diet-induced
fatty liver in rats. The anti-obesity mechanism of Ovothiol-A is associated with its hypolipidemic,
hypoglycemic, and antioxidant properties.