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Review Article

Abutilon indicum: Bioactive Compounds and Diverse Therapeutic Applications

Author(s): Shobhit Prakash Srivastava, Swati Dikshit, Ankita Moharana, Neha Chaturvedi, Saurabh Sharma and Preeti Verma*

Volume 5, 2024

Published on: 17 January, 2024

Article ID: e170124225755 Pages: 8

DOI: 10.2174/0126659786272937240104222224

Price: $65

TIMBC 2025
Abstract

A large variety of secondary metabolites are found in medicinal plants, and the majority are significant in medicine. One of the well-known plant species used to cure a wide range of human illnesses is Abutilon indicum. The plant Abutilon indicum has a wide range of therapeutic uses, and its varied parts have been employed to cure a wide range of ailments. Numerous bioactive substances, such as polyphenols, flavonoids, alkaloids, saponins, tannins, and glycosides are present in the plant. Potent antioxidant, anti-inflammatory, antibacterial, hepatoprotective, hypoglycaemic, analgesic, sedative, and diuretic activities have been demonstrated in these compounds. Additionally, the plant has been shown to have cytoprotective properties and to guard against DNA damage brought on by oxidative stress. Future research is required to pinpoint the specific bioactive chemicals responsible for the pharmacological effects of Abutilon indicum and the molecular mechanisms underlying the plant's therapeutic uses. Overall, Abutilon indicum has demonstrated great therapeutic potential and deserves further study as a possible source of homeopathic treatments for various illnesses. The present study covers a summary of the phytochemical and ethnomedicinal applications of Abutilon Indicum that would further help in exploring the research in natural medicine.

Keywords: Abutilon Indicum, hepatoprotective, antioxidant, hypoglycaemic, soxhlet extraction, bioactive compound.

[1]
Rajeshwari, S.; Sevarkodiyone, S.P. Medicinal properties of Abutilon indicum. Int. J. Res. Phytochem. Pharmacol. Sci., 2018, 1(1), 1-4.
[http://dx.doi.org/10.33974/ijrpps.v1i1.5]
[2]
S, R. Medicinal properties of abutilon indicum. Open J. Plant Sci., 2018, 022-025.
[http://dx.doi.org/10.17352/ojps.000011]
[3]
Ramasubramania Raja, R.; Kailasam, K.V. Abutilon indicum L (Malvaceae)-medicinal potential review. Pharmacogn. J., 2015, 7(6), 330-332.
[http://dx.doi.org/10.5530/pj.2015.6.2]
[4]
Reyad-ul-ferdous, M. Pharmacologicals and phytochemicals potential of abutilon indicum: A comprehensive review. Am. J. Biosci., 2015, 3(2), 5.
[http://dx.doi.org/10.11648/j.ajbio.s.2015030201.12]
[5]
Zhang, H.; Zhu, P. Solid phase extraction. Fenxi Huaxue, 2000, 28
[6]
Ścigalski, P.; Kosobucki, P. Recent materials developed for dispersive solid phase extraction. Molecules, 2020, 25(21), 4869.
[http://dx.doi.org/10.3390/molecules25214869]
[7]
Płotka-Wasylka, J.; Szczepańska, N.; de la Guardia, M.; Namieśnik, J. Miniaturized solid-phase extraction techniques. TrAC Trends Analyt. Chem., 2015, 73, 19-38.
[http://dx.doi.org/10.1016/j.trac.2015.04.026]
[8]
Chisvert, A.; Cárdenas, S.; Lucena, R. Dispersive micro-solid phase extraction. TrAC Trends Analyt. Chem., 2019, 112, 226-233.
[http://dx.doi.org/10.1016/j.trac.2018.12.005]
[9]
Khan, W.A.; Arain, M.B.; Soylak, M. Nanomaterials-based solid phase extraction and solid phase microextraction for heavy metals food toxicity. Food Chem. Toxicol., 2020, 145, 111704.
[http://dx.doi.org/10.1016/j.fct.2020.111704] [PMID: 32853698]
[10]
Wu, X.; Dhanasekaran, S. Protective effect of leaf extract of Abutilon indicum on DNA damage and peripheral blood lymphocytes in combating the oxidative stress. Saudi Pharm. J., 2020, 28(8), 943-950.
[http://dx.doi.org/10.1016/j.jsps.2020.06.015] [PMID: 32792839]
[11]
Sahu, A.N.; Sharma, S. Development, characterization, and evaluation of hepatoprotective effect of abutilon indicum and piper longum phytosomes. Pharmacognosy Res., 2016, 8(1), 29-36.
[http://dx.doi.org/10.4103/0974-8490.171102] [PMID: 26941533]
[12]
Mital, K.A. Analysis of phytochemicals in petroleum ether leaves extract from abutilon pannosum and grewia tenax by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC/Q-TOF-MS) after continuous hot percolation successive soxhlet extraction. IJARCS, 2017, 4(10), 44-52.
[13]
Phan, L.T.M.; Nguyen, K.T.P.; Vuong, H.T.; Tran, D.D.; Nguyen, T.X.P.; Hoang, M.N.; Mai, T.P.; Nguyen, H.H. Supercritical fluid extraction of polyphenols from vietnamese callisia fragrans leaves and antioxidant activity of the extract. J. Chem., 2020, 2020, 1-7.
[http://dx.doi.org/10.1155/2020/9548401]
[14]
Kuo, P.C.; Yang, M.L.; Wu, P.L.; Shih, H.N.; Thang, T.D.; Dung, N.X.; Wu, T.S. Chemical constituents from Abutilon indicum. J. Asian Nat. Prod. Res., 2008, 10(7-8), 699-703.
[PMID: 18636384]
[15]
Singh, R.; Mendhulkar, V.D. FTIR studies and spectrophotometric analysis of natural antioxidants, polyphenols and flavonoids in Abutilon indicum (Linn) Sweet leaf extract. J. Chem. Pharm. Res., 2015, 7.
[16]
Sajjalaguddam, R.; Paladugu, A. Phenylalanine enhances quercetin content in in vitro cultures of abutilon indicum L. J. Appl. Pharm. Sci., 2015, 5, 080-084.
[http://dx.doi.org/ 10.7324/JAPS.2015.501014]
[17]
Nayak, R.; Panda, A.; Samanta, L.; Sahoo, S. Phytochemical Analysis of Antioxidants From Abutilon indicum L. and Paederiafoetida L. Supported by TLC, FTIR and NMR Studies. Int. J. Sci. Res., 2013, 4, 1312-1318.
[18]
Saranya, D.; Sekar, J.; Adaikala Raj, G. Assessment of antioxidant activities, phenol and flavonoid contents of different extracts of leaves, bark, and root from the Abutilon Indicum (L.) sweet. Asian J. Pharm. Clin. Res., 2017, 10, 88-94.
[http://dx.doi.org/10.22159/ajpcr.2017.v10i4.15884]
[19]
Ntalouka, F.; Tsirivakou, A. Luteolin: A promising natural agent in management of pain in chronic conditions. Front. Pain Res., 2023, 4, 1114428.
[20]
Ganeshpurkar, A.; Saluja, A.K. The pharmacological potential of rutin. Saudi Pharm. J., 2017, 25(2), 149-164.
[http://dx.doi.org/10.1016/j.jsps.2016.04.025]
[21]
Laura de Cabral Sobreira, A. Phytochemical and pharmacological aspects of the alkaloids of malvaceae sensu lato species: A review. Quim. Nov., 2023, 46(5)
[22]
Cushnie, T.P.T.; Cushnie, B.; Lamb, A.J. Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities. Int. J. Antimicrob. Agents, 2014, 44(5), 377-386.
[http://dx.doi.org/10.1016/j.ijantimicag.2014.06.001]
[23]
Dickschat, J.S. Terpenes. Beilstein J. Org. Chem., 2019, 15, 2699-2967.
[http://dx.doi.org/10.3762/bjoc.15.292]
[24]
Nunes, C.R.; Barreto Arantes, M.; Menezes de Faria Pereira, S.; Leandro da Cruz, L.; de Souza Passos, M.; Pereira de Moraes, L.; Vieira, I.J.C.; Barros de Oliveira, D. Plants as sources of anti-inflammatory agents. Molecules, 2020, 25(16), 3726.
[http://dx.doi.org/10.3390/molecules25163726] [PMID: 32824133]
[25]
Shingala, Z.; Chauhan, B.; Baraiya, J. A review on medicinal plants as a source of anti-inflammatory agents. J. Pharmacogn. Phytochem., 2021, 10(6), 364-371.
[http://dx.doi.org/10.22271/phyto.2021.v10.i6e.14313]
[26]
Woguem, V.; Fogang, H.P.D.; Maggi, F.; Tapondjou, L.A.; Womeni, H.M.; Quassinti, L.; Bramucci, M.; Vitali, L.A.; Petrelli, D.; Lupidi, G.; Papa, F.; Vittori, S.; Barboni, L. Volatile oil from striped African pepper (Xylopia parviflora, Annonaceae) possesses notable chemopreventive, anti-inflammatory and antimicrobial potential. Food Chem., 2014, 149, 183-189.
[http://dx.doi.org/10.1016/j.foodchem.2013.10.093] [PMID: 24295693]
[27]
Hussain, M.S.; Fareed, S.; Ali, M.; Rahman, M.A. Validation of the method for the simultaneous estimation of bioactive marker gallic acid and quercetin in Abutilon indicum by HPTLC. Asian Pac. J. Trop. Dis., 2012, 2, S76-S83.
[http://dx.doi.org/10.1016/S2222-1808(12)60127-3]
[28]
Khan, H.; Ullah, H.; Aschner, M.; Cheang, W.S.; Akkol, E.K. Neuroprotective effects of quercetin in alzheimer’s disease. Biomolecules, 2020, 10(1), 59.
[http://dx.doi.org/10.3390/biom10010059]
[29]
Prasathkumar, M.; Anisha, S.; Dhrisya, C.; Becky, R.; Sadhasivam, S. Therapeutic and pharmacological efficacy of selective Indian medicinal plants - A review. Phytomed. Plus, 2021, 1(2), 100029.
[http://dx.doi.org/10.1016/j.phyplu.2021.100029]
[30]
Surywanshi, V.S.; Umate, S.R. A review on phytochemical constituents of abutilon indicum (link) sweet – an important medicinal plant in ayurveda. Plant Sci., 2020, 3, 15-19.
[31]
dos Santos, É.R.Q.; Maia, J.G.S.; Fontes-Júnior, E.A.; do Socorro Ferraz Maia, C. Linalool as a therapeutic and medicinal tool in depression treatment: A review. Curr. Neuropharmacol., 2022, 20(6), 1073-1092.
[http://dx.doi.org/10.2174/1570159X19666210920094504] [PMID: 34544345]
[32]
Santos, B.C.S.; Pires, A.S.; Yamamoto, C.H.; Couri, M.R.C.; Taranto, A.G.; Alves, M.S.; Araújo, A.L.S.M.; de Sousa, O.V. Methyl chavicol and its synthetic analogue as possible antioxidant and antilipase agents based on the in vitro and in silico assays. Oxid. Med. Cell. Longev., 2018, 2018, 1-11.
[http://dx.doi.org/10.1155/2018/2189348] [PMID: 29849872]
[33]
Nisar, M.F. Pharmacological properties and health benefits of eugenol: A comprehensive review. Oxid. Med. Cell. Longev., 2021, 2021, 2497354.
[http://dx.doi.org/10.1155/2021/2497354]
[34]
Surendran, S.; Qassadi, F.; Surendran, G.; Lilley, D.; Heinrich, M. Myrcene-what are the potential health benefits of this flavouring and aroma agent? Front. Nutr., 2021, 8, 699666.
[http://dx.doi.org/10.3389/fnut.2021.699666]
[35]
Anandakumar, P.; Kamaraj, S.; Vanitha, M.K. D-limonene: A multifunctional compound with potent therapeutic effects. J. Food Biochem., 2021, 45(1), e13566.
[http://dx.doi.org/10.1111/jfbc.13566]
[36]
De Brito Passos, F. F. Involvement of cholinergic and opioid system in γ-terpinene-mediated antinociception. Evidence-based Complement. Altern. Med., 2015, 2015
[37]
Legault, J.; Pichette, A. Potentiating effect of β-caryophyllene on anticancer activity of α-humulene, isocaryophyllene and paclitaxel. J. Pharm. Pharmacol., 2010, 59(12), 1643-1647.
[http://dx.doi.org/10.1211/jpp.59.12.0005] [PMID: 18053325]
[38]
Gaikwad, S. B.; Mohan, G. K. Atibala: An overview. J. Pharmaceut. Res. Health Care, 2011, 3
[39]
Sivasubramanian, P.; Devi, R.G.; Selvaraj, J.; Priya, A.J. A comparative study of anti-inflammatory activity of tecoma stans, acalypha indica and abutilon indicum plant leaf extract. J. Pharm. Res. Int., 2021, 298-306.
[http://dx.doi.org/10.9734/jpri/2021/v33i58A34119]
[40]
Vessal, M.; Hemmati, M.; Vasei, M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 2003, 135(3), 357-364.
[http://dx.doi.org/10.1016/S1532-0456(03)00140-6] [PMID: 12927910]
[41]
Bule, M.; Abdurahman, A.; Nikfar, S.; Abdollahi, M.; Amini, M. Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies. Food Chem. Toxicol., 2019, 125, 494-502.
[http://dx.doi.org/10.1016/j.fct.2019.01.037]
[42]
Baek, S. J.; Krisanapun, C.; Lee, S. H.; Peungvicha, P.; Temsiririrkkul, R. Antidiabetic activities of abutilon indicum (L.) sweet are mediated by enhancement of adipocyte differentiation and activation of the GLUT1 promoter. Evidence-based Complement. Altern. Med., 2011, 2011
[43]
Kaushik, P.; Kaushik, D.; Khokra, S.L.; Sharma, A. Antidiabetic activity of the plant Abutilon indicum in streptozotocin-induced experimental diabetes in rats. Int. J. Pharmacogn. Phytochem. Res., 2010, 2, 45-49.
[44]
Sharma, Kr. Scholars research library preliminary phytochemical and pharmacognostic profile of abutilon indicum linn. root. Pharm. Lett., 2010, 2, 308-315.
[45]
Kashinath Patel, M.; Rajput, A.P. Therapeutic significance of abutilon indicum: An overview. Am. J. PharmTech Res., 2013, 3, 20-35.
[46]
Mehta, A.A.; Paranjape, A.N. Investigation into the mechanism of action of abutilon indicum in the treatment of bronchial asthma. Glob. J. Pharmacol., 2008, 2, 23-30.
[47]
Chandrashekhar, V.M.; Nagappa, A.N.; Channesh, T.S.; Habbu, P.V.; Rao, K.P. Anti-diarrhoeal activity of Abutilon indicum linn leaf extracts. J. Nat. Rem., 2004, 4, 12-16.
[48]
Thanish Ahamed, S. Anti-inflammatory activity of Abutilon indicum. Drug Invent. Today, 2019, 11, 1637-1639.
[49]
Sudarshana, M.S.; Nissar, A.R.; Girish, H.V. In vitro regenerative potentials of the medicinal plant Abutilon indicum (L.). Sweet. Afr. J. Biotechnol., 2016, 15(12), 472-480.
[http://dx.doi.org/10.5897/AJB2015.14887]
[50]
Sharma, S.K.; Sharma, S.M.; Vipin, S.; Sharmistha, M. Evaluation of analgesic and anti-inflammatory activity of Abutilon indicum. Int. J. Drug Dev. Res., 2013, 5, 402-407.
[51]
Reyad-ul-Ferdous, M. Biologically potential for pharmacologicals and phytochemicals of medicinal plants of colocasia esculenta: A comprehensive review. Am. J. Clin. Exper. Med., 2015, 3(5), 7.
[http://dx.doi.org/10.11648/j.ajcem.s.2015030501.12]
[52]
González-Barraza, L.; Díaz-Godínez, R.; Castillo-Guevara, C.; Nieto-Camacho, A.; Méndez-Iturbide, D. Phenolic compounds: Presence, identification and antioxidant activity in plants and fruits. Mex. J. Biotechnol., 2017, 2, 46-64.
[http://dx.doi.org/10.29267/mxjb.2017.2.1.46]
[53]
Mata, R.; Nakkala, J.R.; Sadras, S.R. Biogenic silver nanoparticles from Abutilon indicum: Their antioxidant, antibacterial and cytotoxic effects in vitro. Colloids Surf. B Biointerfaces, 2015, 128, 276-286.
[http://dx.doi.org/10.1016/j.colsurfb.2015.01.052] [PMID: 25701118]
[54]
Seetharam, Y.N.; Chalageri, G.; Setty, S.R. Bheemachar, Hypoglycemic activity of Abutilon indicum leaf extracts in rats. Fitoterapia, 2002, 73(2), 156-159.
[http://dx.doi.org/10.1016/S0367-326X(02)00015-1] [PMID: 11978431]
[55]
Krisanapun, C.; Peungvicha, P.; Temsiririrkkul, R.; Wongkrajang, Y. Aqueous extract of Abutilon indicum Sweet inhibits glucose absorption and stimulates insulin secretion in rodents. Nutr. Res., 2009, 29(8), 579-587.
[http://dx.doi.org/10.1016/j.nutres.2009.07.006] [PMID: 19761892]
[56]
Gupta, R.; Patil, S.; Shetty, D. Hepatoprotective activity of hydroalcoholic and ethyl acetate extract of abutilon indicum leaf on rats. Int. J. Pharm. Sci. Rev. Res., 2015, 31, 68-71.
[57]
Porchezhian, E.; Ansari, S.H. Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats. Phytomedicine, 2005, 12(1-2), 62-64.
[http://dx.doi.org/10.1016/j.phymed.2003.09.009] [PMID: 15693709]

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