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Current Organic Synthesis

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ISSN (Online): 1875-6271

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Mini-Review Article

A Review of the Synthesis of Oxazoline Derivatives

Author(s): Cynthia Nathalia Pereira, Amanda Cristina Cruz Eschholz and Maurício Silva dos Santos*

Volume 22, Issue 2, 2025

Published on: 12 January, 2024

Page: [184 - 197] Pages: 14

DOI: 10.2174/0115701794283180231228075225

Price: $65

TIMBC 2025
Abstract

Oxazolines are important heterocyclic systems due to their biological activities, such as antibacterial, antimalarial, anticancer, antiviral, anti-inflammatory, antifungal, antipyretic, and antileishmanial. They have been widely applied as chiral auxiliaries, polymers, catalysts, protecting groups, building blocks, and ligands in asymmetric synthesis. Due to their importance, many synthetic routes to prepare oxazoline moieties have been investigated and developed by researchers around the world. In this review, we summarized several synthetic methodologies published in the literature. The main substrates are nitriles, carboxylic acids, and acid derivatives, which react with a variety of reactants under conventional heating, microwave irradiation or ultrasound irradiation conditions. Syntheses via intramolecular cyclisation from amides have also been reported. Many publications have highlighted procedures based on solvent-free conditions using eco-friendly, reusable, and easy-availability catalysts.

Keywords: Oxazolines, organic synthesis, solvent-free synthesis, microwave irradiation, ultrasound irradiation, chemoselectivity.

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