Title:Bibliometric Analysis to Improve Combined Treatment Strategies for
Glioblastoma in America
Volume: 20
Issue: 6
Author(s): José Molina-García, David Vázquez, Ernesto Piñón, Alonso Portilla, Martha Lilia Tena-Suck, Angel Lee and Carmen Rubio*
Affiliation:
- Departamento de Neurofisiología, Instituto Nacional de Neurología y Neurocirugía "MVS", Ciudad de México,
Mexico
Keywords:
Bibliometry, glioblastoma, radiotherapy, chemotherapy, temozolomide, cancer.
Abstract:
Introduction: Bibliometric analysis quantitatively examines scientific literature to extract
insights. This article has conducted such analysis on glioblastoma multiforme (GBM) treatment articles.
GBM, a prevalent brain tumor, is typically treated with surgery, radiation, and chemotherapy.
Objectives: The article aimed to bibliometrically analyze articles discussing combined GBM treatment
to identify impactful research areas and encourage collaboration.
Materials and Methods: The study encompassed a comprehensive search in the Scopus database,
spanning articles published from 1974 to 2022. Inclusion criteria encompassed research conducted in
the Americas, both clinical and experimental. A total of 772 articles were collected and categorized
based on their primary focus on combined treatment approaches.
Results: Clinical studies constituted 52% of articles, suggesting a slight dominance. The analysis unveiled
key research moments, including a 1998 focus shift and a pivotal 2005 study on temozolomide-
radiation combination. Top journals, trends, and authors were identified, with the USA
leading in contributions.
Discussions: Despite high brain tumor incidence, research distribution discrepancy is concerning.
Regional epidemiological studies have been endorsed. The dominance of US and German authors in
GBM collaboration has raised equity issues due to budget and GDP disparities limiting Latin American
representation.
Conclusion: GBM research in the region is dominated by the USA, while contributions from Latin
American countries remain limited. The absence of comprehensive epidemiological studies on GBM
in Latin America is concerning, considering the evident impact of the disease in the region. This underscores
the urgent need for increased research participation and collaboration to advance the understanding
and treatment of GBM across Latin American nations.
