Title:Modular Edge Analysis Reveals Chemotherapy-induced Brain Network
Changes in Lung Cancer Patients
Volume: 20
Author(s): Jia You, Zhengqian Wang, Lanyue Hu, Yujie Zhang, Feifei Chen, Xindao Yin, Yu-Chen Chen*Xiaomin Yong*
Affiliation:
- Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
- Department of Radiology, Nanjing Pukou People's Hospital, Nanjing, China
Keywords:
Lung cancer, Chemotherapy, s-fMRI, Modular edge analysis, Brain network, Smoking. Article
Abstract:
Background:
Lung cancer patients with post-chemotherapy may have disconnected or weakened function connections within brain networks.
Objective:
This study aimed to explore the abnormality of brain functional networks in lung cancer patients with post-chemotherapy by modular edge
analysis.
Methods:
Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed on 40 patients after chemotherapy, 40 patients before
chemotherapy and 40 normal controls. Patients in all three groups were age and sex well-matched. Then, modular edge analysis was applied to
assess brain functional network alterations.
Results:
Post-chemotherapy patients had the worst MoCA scores among the three groups (p < 0.001). In intra-modular connections, compared with normal
controls, the patients after chemotherapy had decreased connection strengths in the occipital lobe module (p < 0.05). Compared with the nonchemotherapy
group, the patients after chemotherapy had decreased connection strengths in the subcortical module (p < 0.05). In inter-modular
connections, compared with normal controls, the patients after chemotherapy had decreased connection strength in the frontal-temporal lobe
modules (p < 0.05). Compared with the non-chemotherapy group, the patients after chemotherapy had decreased connection strength in the
subcortical-temporal lobe modules (p < 0.05).
Conclusion:
The results reveal that chemotherapy can disrupt connections in brain functional networks. As far as we know, the use of modular edge analysis to
report changes in brain functional brain networks associated with chemotherapy was rarely reported. Modular edge analysis may play a crucial part
in predicting the clinical outcome for the patients after chemotherapy.
