Title:Natural Excipients: Role in Nano Drug Delivery System
Volume: 9
Author(s): Pranita Jirwankar, Surendra Agrawal*, Fuzail Shaikh and Kadambari Borse
Affiliation:
- Datta Meghe College of Pharmacy, DMIHER (DU), Salod (H), Wardha, MS, India
Keywords:
Natural Excipient in Nanoformulation, Marine source polymer in nanoformulation, Animal source excipients in nanoformulation, Nanoformulations with natural excipients, Roel of natural excipients in nanoformulations, Nanomaterials from natural source
Abstract: Background: Excipients are increasingly employed in novel dosage forms to accomplish
specialized roles, and they also directly or indirectly alter the extent and rate of drug release and
absorption. The trend toward using plant-based and natural goods has raised demand and, in some
ways, replaced synthetic additives with natural ones. Natural and semisynthetic materials offer various
advantages over synthetic materials since they are chemically inert, less toxic, less expensive,
biodegradable, increase product shelf life, and are widely accessible.
Objectives: This review aims to cover the natural excipients’ role in nanoformulations and associated
prospects.
Methods: More than 500 manuscripts were collected from ScienceDirect, PubMed, google, and
other sources; however the manuscripts were excluded based on their relevance to the subject and
finally 80 manuscripts were analyzed for the data.
Results: The substation of synthetic lipids with natural and semisynthetic for developing lipid-based
nano drug delivery, and the use of gelatin and chitosan in developing encapsulated and nano particulates
are a few examples to understand the above-mentioned transition.
Conclusion: This review provides an overview of the types of excipients used in the formulation of
novel drug delivery systems with special emphasis on their characteristics, safety aspects, benefits
associated, and common methods through, which they are employed in nanoformulations.
