Title:GDF-10 Induces an Inhibitory Effect on Epithelial-Mesenchymal Transition of
Laryngeal Cancer via LPR4
Volume: 29
Issue: 43
Author(s): Xuan Kan, Li Ai, Ruidi Guan, Jianwei Hao, Yanan Sun and Wei Xiu*
Affiliation:
- Department of Pharmacy, Heilongjiang Forest Industry General Hospital, Harbin 150040, China
Keywords:
Laryngeal cancer, EMT, GDF-10, LRP4, TGF-β, tumor progression.
Abstract:
Background: Growth differentiation factor-10 (GDF-10), a member of the TGF-β superfamily,
plays a crucial role in cell proliferation and differentiation. In some tumors, GDF-10 can act as a tumor suppressor
to inhibit tumor progression, but its role in posterior squamous cell carcinoma has not been reported yet.
Methods: The aim of this study was to investigate the effect of GDF-10 on the epithelial-mesenchymal transition
of laryngeal squamous cell carcinoma, and to provide new ideas for future targets in the treatment of laryngeal
squamous carcinoma.
Results: The effect of GDF-10 on tumor growth was detected; bioinformatics analysis was performed to predict
the downstream targets of GDF-10, and RT-PCR and western blot were performed to detect the expression
levels of target genes and proteins, respectively.
Conclusion: Our findings support that GDF-10 can inhibit the proliferation, migration, and invasion, and promote
apoptosis of laryngeal carcinoma AMC-HN-8 cells. GDF-10 inhibits the EMT of laryngeal carcinoma
through LRP4 and thus inhibits the progression of laryngeal carcinoma.
