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Review Article

The Role of Resveratrol in Alzheimer's Disease: A Comprehensive Review of Current Research

Author(s): Shivendra Kumar*, Sunam Saha, Bhawna Sharma, Shubham Singh, Piyush Shukla, Soumyadip Mukherjee, Mohit Agrawal, Kuldeep Singh and Talever Singh

Volume 2, Issue 2, 2024

Published on: 12 December, 2023

Article ID: e121223224364 Pages: 13

DOI: 10.2174/0126668629269244231127071411

Price: $65

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and impaired daily functioning. The etiology of AD is complex and multifactorial, involving various pathological mechanisms such as the accumulation of amyloid-beta plaques, neurofibrillary tangles, neuroinflammation, and oxidative stress. As the global prevalence of AD continues to rise, there is a growing interest in identifying potential therapeutic interventions to prevent or slow down the progression of the disease. Resveratrol, a natural polyphenolic compound found in various plant sources such as grapes, berries, and peanuts, has gained considerable attention due to its potential neuroprotective effects. Numerous preclinical studies utilizing in vitro and animal models have investigated the impact of resveratrol on AD pathology and associated cognitive impairments. This review aims to provide a comprehensive summary of the current research on the role of resveratrol in AD. In conclusion, resveratrol holds promise as a potential therapeutic agent for AD due to its ability to target multiple pathological processes involved in the disease. Further research, including well-designed clinical trials with larger sample sizes, is needed to fully elucidate the efficacy, optimal dosage, and long-term effects of resveratrol in AD patients. Nevertheless, resveratrol remains an intriguing compound with neuroprotective properties and may contribute to the development of novel therapeutic approaches for AD in the future.

Keywords: Alzheimer's disease, resveratrol, amyloid-beta, neurofibrillary tangles, oxidative stress, neuroinflammation, synaptic plasticity, neurogenesis, clinical trials.

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