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Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Systematic Review Article

A Review of the Occurrence of Rheumatoid Arthritis and Potential Treatments through Medicinal Plants from an Indian Perspective

Author(s): Mohammad Raeesh Shekh*, Nasir Ahmed and Vivek Kumar

Volume 20, Issue 3, 2024

Published on: 28 November, 2023

Page: [241 - 269] Pages: 29

DOI: 10.2174/0115733971268416231116184056

Price: $65

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Abstract

Arthritis is a medical condition that affects the joints and causes inflammation, pain, and stiffness. There are different types of arthritis, and it can affect people of all ages, even infants and the elderly. Recent studies have found that individuals with diabetes, heart disease, and obesity are more likely to experience arthritis symptoms. According to the World Health Organization, over 21% of people worldwide suffer from musculoskeletal problems. Roughly 42.19 million individuals in India, constituting around 0.31% of the populace, have been documented as having Rheumatic Arthritis (RA).

Compared to other common diseases like diabetes, cancer, and AIDS, arthritis is more prevalent in the general population. Unfortunately, there is no specific cure for arthritis, and treatment plans usually involve non-pharmacological methods, surgeries, and medications that target specific symptoms. Plant-based remedies have also been shown to be effective in managing inflammation and related complications. In addition to therapies, maintaining a healthy diet, exercise, and weight management are essential for managing arthritis.

This review discusses the causes, prevalence, diagnostic methods, current and prospective future treatments, and potential medicinal plants that may act as anti-inflammatory or anti-rheumatic agents. However, more research is necessary to identify the underlying mechanisms and active molecules that could improve arthritis treatment.

Keywords: Rheumatoid, anti-inflammatory, inflammation, autoimmune, etiology, medicinal plants, phytochemicals, prevalence.

Graphical Abstract
[1]
Smolen JS, Aletaha D, Barton A, et al. Rheumatoid arthritis. Nat Rev Dis Primers 2018; 4(1): 18001.
[http://dx.doi.org/10.1038/nrdp.2018.1] [PMID: 29417936]
[2]
Chandrasekhar AN. Infection and arthritis. J Assoc Physicians India 2006; 54 (Suppl.): 27-31.
[PMID: 16909713]
[3]
Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30(11): 1205-13.
[http://dx.doi.org/10.1002/art.1780301102] [PMID: 2446635]
[4]
Safiri S, Kolahi AA, Hoy D, et al. Global, regional and national burden of rheumatoid arthritis 1990-2017: A systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis 2019; 78(11): 1463-71.
[http://dx.doi.org/10.1136/annrheumdis-2019-215920 ] [PMID: 31511227]
[5]
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365(23): 2205-19.
[http://dx.doi.org/10.1056/NEJMra1004965] [PMID: 22150039]
[6]
Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac’h N, Falgarone G. Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction. J Autoimmun 2012; 39(3): 222-8.
[http://dx.doi.org/10.1016/j.jaut.2012.05.021] [PMID: 22704962]
[7]
Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008; 320(5876): 674-7.
[http://dx.doi.org/10.1126/science.1156995] [PMID: 18403674]
[8]
Sidiropoulos PI, Goulielmos G, Voloudakis GK, Petraki E, Boumpas DT. Inflammasomes and rheumatic diseases: Evolving concepts. Ann Rheum Dis 2008; 67(10): 1382-9.
[http://dx.doi.org/10.1136/ard.2007.078014] [PMID: 17921182]
[9]
Anić B, Mayer M. Patogeneza reumatoidnog artritisa. Reumatizam 2014; 61(2): 19-23.
[PMID: 25427390]
[10]
Janossy G, Duke O, Poulter LW, Panayi G, Bofill M, Goldstein G. Rheumatoid arthritis: A disease of T-lymphocyte/macrophage immunoregulation. Lancet 1981; 318(8251): 839-42.
[http://dx.doi.org/10.1016/S0140-6736(81)91107-7] [PMID: 6116956]
[11]
Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 1988; 31(10): 1230-8.
[http://dx.doi.org/10.1002/art.1780311003] [PMID: 3263133]
[12]
Hata H, Sakaguchi N, Yoshitomi H, et al. Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice. J Clin Invest 2004; 114(4): 582-8.
[http://dx.doi.org/10.1172/JCI200421795] [PMID: 15314695]
[13]
Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Ann rev of immunol 1996; 14(1): 397-440.
[http://dx.doi.org/10.1146/annurev.immunol.14.1.397]
[14]
Pincus T, Callahan LF. What is the natural history of rheumatoid arthritis? Rheum Dis Clin North Am 1993; 19(1): 123-51.
[http://dx.doi.org/10.1016/S0889-857X(21)00171-X ] [PMID: 8356248]
[15]
Mielants H, Van den Bosch F. Extra-articular manifestations. Clin Exp Rheumatol 2009; 27(4) (Suppl. 55): S56-61.
[PMID: 19822047]
[16]
Young A, Koduri G. Extra-articular manifestations and complications of rheumatoid arthritis. Best Pract Res Clin Rheumatol 2007; 21(5): 907-27.
[http://dx.doi.org/10.1016/j.berh.2007.05.007] [PMID: 17870035]
[17]
Reginster JY. The prevalence and burden of arthritis. Rheumatology (Oxford) 2002; 41 (Suppl. 1): 3-6.
[http://dx.doi.org/10.1093/rheumatology/41.S1.3] [PMID: 12173279]
[18]
Cross M, Smith E, Hoy D, et al. The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis 2014; 73(7): 1316-22.
[http://dx.doi.org/10.1136/annrheumdis-2013-204627 ] [PMID: 24550173]
[19]
Gibofsky A. Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am J Manag Care 2012; 18(13) (Suppl.): S295-302.
[PMID: 23327517]
[20]
Almoallim H, Al Saleh J, Badsha H, et al. A Review of the prevalence and unmet needs in the management of rheumatoid arthritis in Africa and the Middle East. Rheumatol Ther 2021; 8(1): 1-16.
[http://dx.doi.org/10.1007/s40744-020-00252-1] [PMID: 33226566]
[21]
Rudan I, Sidhu S, Papana A, et al. Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis. J Glob Health 2015; 5(1): 010409.
[http://dx.doi.org/10.7189/jogh.05.010409] [PMID: 25969732]
[23]
Klareskog L, Rönnelid J, Saevarsdottir S, Padyukov L, Alfredsson L. The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis. J Intern Med 2020; 287(5): 514-33.
[http://dx.doi.org/10.1111/joim.13058] [PMID: 32176395]
[24]
Astorga GP, Williams RC Jr. Altered reactivity in mixed lymphocyte culture of lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum 1969; 12(6): 547-54.
[http://dx.doi.org/10.1002/art.1780120602] [PMID: 5363253]
[25]
Kochi Y, Suzuki A, Yamamoto K. Genetic basis of rheumatoid arthritis: A current review. Biochem Biophys Res Commun 2014; 452(2): 254-62.
[http://dx.doi.org/10.1016/j.bbrc.2014.07.085] [PMID: 25078624]
[26]
Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 2003; 34(4): 395-402.
[http://dx.doi.org/10.1038/ng1206] [PMID: 12833157]
[27]
Kochi Y, Okada Y, Suzuki A, et al. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet 2010; 42(6): 515-9.
[http://dx.doi.org/10.1038/ng.583] [PMID: 20453841]
[28]
Wang S, Wang Y. Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis. Biochim Biophys Acta Gene Regul Mech 2013; 1829(10): 1126-35.
[http://dx.doi.org/10.1016/j.bbagrm.2013.07.003] [PMID: 23860259]
[29]
Begovich AB, Carlton VEH, Honigberg LA, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004; 75(2): 330-7.
[http://dx.doi.org/10.1086/422827] [PMID: 15208781]
[30]
Bottini N, Peterson EJ. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annu Rev Immunol 2014; 32(1): 83-119.
[http://dx.doi.org/10.1146/annurev-immunol-032713-120249] [PMID: 24364806]
[31]
Tizaoui K, Terrazzino S, Cargnin S, et al. The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review. In: Seminar in arthritis and rheumatism. 2021; 51: pp. (3)513-22.
[32]
Thomson W, Barton A, Ke X, et al. Rheumatoid arthritis association at 6q23. Nat Genet 2007; 39(12): 1431-3.
[http://dx.doi.org/10.1038/ng.2007.32] [PMID: 17982455]
[33]
Holbrook J, Lara-Reyna S, Jarosz-Griffiths H, McDermott MF. Tumour necrosis factor signalling in health and disease. F1000 Res 2019; 8(111): 111.
[http://dx.doi.org/10.12688/f1000research.17023.1 ] [PMID: 30755793]
[34]
Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007; 357(10): 977-86.
[http://dx.doi.org/10.1056/NEJMoa073003] [PMID: 17804842]
[35]
Liao KP, Alfredsson L, Karlson EW. Environmental influences on risk for rheumatoid arthritis. Curr Opin Rheumatol 2009; 21(3): 279-83.
[http://dx.doi.org/10.1097/BOR.0b013e32832a2e16 ] [PMID: 19318947]
[36]
Collins KH, Herzog W, MacDonald GZ, et al. Obesity, metabolic syndrome, and musculoskeletal disease: Common inflammatory pathways suggest a central role for loss of muscle integrity. Front Physiol 2018; 9: 112.
[http://dx.doi.org/10.3389/fphys.2018.00112] [PMID: 29527173]
[37]
Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003; 81(9): 646-56.
[PMID: 14710506]
[40]
Kowal P, Chatterji S, Naidoo N, et al. Data resource profile: the World Health Organization Study on global AGEing and adult health (SAGE). Int J Epidemiol 2012; 41(6): 1639-49.
[http://dx.doi.org/10.1093/ije/dys210] [PMID: 23283715]
[41]
Brennan-Olsen SL, Cook S, Leech MT, et al. Prevalence of arthritis according to age, sex and socioeconomic status in six low and middle income countries: Analysis of data from the World Health Organization study on global AGEing and adult health (SAGE) Wave 1. BMC Musculoskelet Disord 2017; 18(1): 271.
[http://dx.doi.org/10.1186/s12891-017-1624-z] [PMID: 28633661]
[42]
Gonzalez A, Kremers H, Crowson CS, et al. The widening mortality gap between rheumatoid arthritis patients and the general population. Arthritis Rheum 2007; 56(11): 3583-7.
[http://dx.doi.org/10.1002/art.22979] [PMID: 17968923]
[43]
Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta‐analysis of observational studies. Arthritis Care Res 2008; 59(12): 1690-7.
[http://dx.doi.org/10.1002/art.24092] [PMID: 19035419]
[44]
Handa R, Rao URK, Lewis JFM, Rambhad G, Shiff S, Ghia CJ. Literature review of rheumatoid arthritis in India. Int J Rheum Dis 2016; 19(5): 440-51.
[http://dx.doi.org/10.1111/1756-185X.12621] [PMID: 26171649]
[45]
Chopra A, Patil J, Billempelly V, Relwani J, Tandle HS. Prevalence of rheumatic diseases in a rural population in western India: A WHO-ILAR COPCORD Study. J Assoc Physicians India 2001; 49: 240-6.
[PMID: 11225138]
[46]
Joshi VL, Chopra A. Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan model. J Rheumatol 2009; 36(3): 614-22.
[http://dx.doi.org/10.3899/jrheum.080675] [PMID: 19208598]
[47]
Malaviya AN, Kapoor SK, Singh RR, Kumar A, Pande I. Prevalence of rheumatoid arthritis in the adult Indian population. Rheumatol Int 1993; 13(4): 131-4.
[http://dx.doi.org/10.1007/BF00301258] [PMID: 8310203]
[48]
Mahajan A, Jasrotia DS, Manhas AS, Jamwal SS. Prevalence of major rheumatic disorders in Jammu. JK Sci 2003; 5(2): 63-6.
[49]
Rajesh M, Somnath V. spectrum of rheumatic disease in Kashmir valley, northern India. Int J Med Sci Diagnosis Res 2019; 3(4): 73-92.
[50]
Kar N. A short communication on occurrence of rheumatic diseases attending hospital. Indian J Public Health 1994; 38(3): 115-8.
[PMID: 7774973]
[51]
Mathew AJ, Goyal V, George E, Thekkemuriyil DV, Jayakumar B, Chopra A. Rheumatic-musculoskeletal pain and disorders in a naïve group of individuals 15 months following a Chikungunya viral epidemic in south India: a population based observational study. Int J Clin Pract 2011; 65(12): 1306-12.
[http://dx.doi.org/10.1111/j.1742-1241.2011.02792.x ] [PMID: 22093538]
[52]
Alok R, Srivastava R, Kumar P, Das SK, Agarwal GG, Dhaon P. Prevalence of rheumatic musculoskeletal symptoms in rural and urban areas: A cross‐sectional study in northern India. Int J Rheum Dis 2017; 20(11): 1638-47.
[http://dx.doi.org/10.1111/1756-185X.13189] [PMID: 29077271]
[53]
Suman S, Kumar R, Jyoti D, Agrawal PK, Parmar V. Clinical profile of acute rheumatic fever patients attending a tertiary care hospital in eastern Bihar, India. Int J Adv Med 2017; 4(5): 1218-21.
[http://dx.doi.org/10.18203/2349-3933.ijam20173609]
[54]
Chandrasekhar S, Koripella R. Seroprevalence of rheumatoid factor in arthritis cases in a teritiary care hospital. Int J Curr Microbiol Appl Sci 2017; 6(12): 1925-8.
[http://dx.doi.org/10.20546/ijcmas.2017.612.219]
[55]
Kumar B, Das MP, Misra AK. A cross-sectional study of association of Rheumatoid arthritis with sero-positivity and anaemia in a tertiary care teaching hospital. J Med Res 2017; 3(6): 280-3.
[http://dx.doi.org/10.31254/jmr.2017.3608]
[56]
Chopra A. Disease burden of rheumatic diseases in India: COPCORD perspective. Indian J Rheumatol 2015; 10(2): 70-7.
[http://dx.doi.org/10.1016/j.injr.2015.04.002]
[57]
Kulkarni S, Bhaskar K, Chillargi C, Havale NK. Study of prevalence of rheumatoid arthritis in bidar population: a hospital based study. Res J Pharm Biol Chem Sci 2015; 6(1): 1332-6.
[58]
Ong CKS, Lirk P, Tan CH, Seymour RA. An evidence-based update on nonsteroidal anti-inflammatory drugs. Clin Med Res 2007; 5(1): 19-34.
[http://dx.doi.org/10.3121/cmr.2007.698] [PMID: 17456832]
[59]
Whittle SL, Colebatch AN, Buchbinder R, et al. Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative. Rheumatology (Oxford) 2012; 51(8): 1416-25.
[http://dx.doi.org/10.1093/rheumatology/kes032] [PMID: 22447886]
[60]
Benjamin O, Goyal A, Lappin SL. Disease Modifying Anti-Rheumatic Drugs (DMARD). Treasure Island, Florida: StatPearls Publishing LLC 2022.
[61]
Van Doornum S, McColl G, Wicks IP. Tumour necrosis factor antagonists improve disease activity but not arterial stiffness in rheumatoid arthritis. Rheumatology (Oxford) 2005; 44(11): 1428-32.
[http://dx.doi.org/10.1093/rheumatology/kei033] [PMID: 16076882]
[62]
Kholmurodovich UF. Damage to the digestive system when using non-steroidal anti-inflammatory drugs. Eur J Mod Med and Pract 2022; 2(1): 6-16.
[63]
Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res 2018; 6(1): 15.
[http://dx.doi.org/10.1038/s41413-018-0016-9] [PMID: 29736302]
[64]
Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol 2013; 9(1): 30.
[http://dx.doi.org/10.1186/1710-1492-9-30] [PMID: 23947590]
[65]
Aly AM, Furst DE. Update of sarilumb to treat rheumatoid arthritis based on randomized clinical trials: A systematic review. Expert Rev Clin Immunol 2017; 13(8): 741-52.
[http://dx.doi.org/10.1080/1744666X.2017.1351297 ] [PMID: 28689441]
[66]
Mahajan TD, Mikuls TR. Recent advances in the treatment of rheumatoid arthritis. Curr Opin Rheumatol 2018; 30(3): 231-7.
[http://dx.doi.org/10.1097/BOR.0000000000000496 ] [PMID: 29461286]
[67]
Venkiteshwaran A. Tocilizumab. MAbs 2009; 1(5): 432-8.
[http://dx.doi.org/10.4161/mabs.1.5.9497] [PMID: 20065633]
[68]
McKeage K. A review of CT-P13: an infliximab biosimilar. BioDrugs 2014; 28(3): 313-21.
[http://dx.doi.org/10.1007/s40259-014-0094-1] [PMID: 24723086]
[69]
Hong J, Lee Y, Lee C, et al. Physicochemical and biological characterization of SB2, a biosimilar of Remicade® (infliximab). MAbs 2017; 9(2): 365-83.
[http://dx.doi.org/10.1080/19420862.2016.1264550 ] [PMID: 28005456]
[70]
Derzi M, Johnson TR, Shoieb AM, et al. Nonclinical evaluation of PF-06438179: a potential biosimilar to Remicade®(infliximab). Adv Ther 2016; 33(11): 1964-82.
[http://dx.doi.org/10.1007/s12325-016-0403-9] [PMID: 27585978]
[71]
Dhillon S. Tofacitinib: A review in rheumatoid arthritis. Drugs 2017; 77(18): 1987-2001.
[http://dx.doi.org/10.1007/s40265-017-0835-9] [PMID: 29139090]
[72]
Pine PR, Chang B, Schoettler N, et al. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol 2007; 124(3): 244-57.
[http://dx.doi.org/10.1016/j.clim.2007.03.543] [PMID: 17537677]
[73]
Braselmann S, Taylor V, Zhao H, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther 2006; 319(3): 998-1008.
[http://dx.doi.org/10.1124/jpet.106.109058] [PMID: 16946104]
[74]
Osiri M, Shea B, Robinson V, et al. Leflunomide for the treatment of rheumatoid arthritis: A systematic review and metaanalysis. J Rheumatol 2003; 30(6): 1182-90.
[PMID: 12784387]
[75]
Lipsky PE. Suggested mode of action of D-penicillamine as an immunosuppressive agent in rheumatoid arthritis. Z Rheumatol 1988; 47 (Suppl. 1): 6-8.
[PMID: 2975107]
[76]
Shi JG, Chen X, Lee F, et al. The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers. J Clin Pharmacol 2014; 54(12): 1354-61.
[http://dx.doi.org/10.1002/jcph.354] [PMID: 24965573]
[77]
Weinblatt ME, Keystone EC, Furst DE, et al. Adalimumab, a fully human anti–tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial. Arthritis Rheum 2003; 48(1): 35-45.
[http://dx.doi.org/10.1002/art.10697] [PMID: 12528101]
[78]
Flendrie M, Creemers MC, Welsing PM, den Broeder AA, van Riel PL. Survival during treatment with tumour necrosis factor blocking agents in rheumatoid arthritis. Ann Rheum Dis 2003; 62(90002) (Suppl. 2): 30ii-3.
[http://dx.doi.org/10.1136/ard.62.suppl_2.ii30] [PMID: 14532145]
[79]
Silverman GJ, Weisman S. Rituximab therapy and autoimmune disorders: Prospects for anti–B cell therapy. Arthritis Rheum 2003; 48(6): 1484-92.
[http://dx.doi.org/10.1002/art.10947] [PMID: 12794814]
[80]
Cohen S, Hurd E, Cush J, et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin‐1 receptor antagonist, in combination with methotrexate: Results of a twenty‐four–week, multicenter, randomized, double‐blind, placebo‐controlled trial. Arthritis Rheum 2002; 46(3): 614-24.
[http://dx.doi.org/10.1002/art.10141] [PMID: 11920396]
[81]
Westhovens R, Taylor PC, Alten R, et al. Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: Results from a randomised, dosefinding study (DARWIN 1). Ann Rheum Dis 2016; 75: 142.
[http://dx.doi.org/10.1136/annrheumdis-2016-eular.1954 ] [PMID: 27993829]
[82]
Panush RS, Carter RL, Katz P, Kowsari B, Longley S, Finnie S. Diet therapy for rheumatoid arthritis. Arthritis Rheum 1983; 26(4): 462-71.
[http://dx.doi.org/10.1002/art.1780260403] [PMID: 6838671]
[83]
Gaby AR. Alternative treatments for rheumatoid arthritis. Altern Med Rev 1999; 4(6): 392-402.
[PMID: 10608912]
[84]
Chandrasekar R, Chandrasekar S. Natural herbal treatment for rheumatoid arthritis- a review. Int J Pharm Sci Res 2017; 8(2): 368.
[85]
Wirth JH, Hudgins JC, Paice JA. Use of herbal therapies to relieve pain: a review of efficacy and adverse effects. Pain Manag Nurs 2005; 6(4): 145-67.
[http://dx.doi.org/10.1016/j.pmn.2005.08.003] [PMID: 16337563]
[86]
Choubey J, Patel A, Verma MK. Phytotherapy in the treatment of arthritis: A review. Int J Pharm Sci Res 2013; 4(8): 2853.
[87]
Zheng CJ, Zhao XX, Ai HW, et al. Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund’s adjuvant induced arthritis in rats. Phytomedicine 2014; 21(6): 838-46.
[http://dx.doi.org/10.1016/j.phymed.2014.02.003] [PMID: 24680620]
[88]
Singh D, Aggarwal A, Maurya R, Naik S. Withania somnifera inhibits NF‐ κB and AP‐1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytother Res 2007; 21(10): 905-13.
[http://dx.doi.org/10.1002/ptr.2180] [PMID: 17562568]
[89]
Ganesan K, Sehgal PK, Mandal AB, Sayeed S. Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen. Appl Biochem Biotechnol 2011; 165(3-4): 1075-91.
[http://dx.doi.org/10.1007/s12010-011-9326-8] [PMID: 21789568]
[90]
Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D. Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A. BMC Genomics 2010; 11(S4): S25.
[http://dx.doi.org/10.1186/1471-2164-11-S4-S25]
[91]
Heyninck K, Lahtela-Kakkonen M, Van der Veken P, Haegeman G, Vanden Berghe W. Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ. Biochem Pharmacol 2014; 91(4): 501-9.
[http://dx.doi.org/10.1016/j.bcp.2014.08.004] [PMID: 25159986]
[92]
Francis JA, Raja SN, Nair MG. Bioactive terpenoids and guggulusteroids from Commiphora mukul gum resin of potential anti-inflammatory interest. Chem Biodivers 2004; 1(11): 1842-53.
[http://dx.doi.org/10.1002/cbdv.200490138] [PMID: 17191820]
[93]
Shishodia S, Aggarwal BB. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem 2004; 279(45): 47148-58.
[http://dx.doi.org/10.1074/jbc.M408093200] [PMID: 15322087]
[94]
Lv N, Song MY, Kim EK, Park JW, Kwon KB, Park BH. Guggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic β cells from cytokine toxicity. Mol Cell Endocrinol 2008; 289(1-2): 49-59.
[http://dx.doi.org/10.1016/j.mce.2008.02.001] [PMID: 18343024]
[95]
Niranjan R, Kamat PK, Nath C, Shukla R. Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). J Ethnopharmacol 2010; 127(3): 625-30.
[http://dx.doi.org/10.1016/j.jep.2009.12.012] [PMID: 20018235]
[96]
Manjula N, Gayathri B, Vinaykumar KS, Shankernarayanan NP, Vishwakarma RA, Balakrishnan A. Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF-α, IL-1β and IL-2. Int Immunopharmacol 2006; 6(2): 122-32.
[http://dx.doi.org/10.1016/j.intimp.2005.07.001] [PMID: 16399617]
[97]
Abdel-Tawab M, Werz O, Schubert-Zsilavecz M. Boswellia serrata. Clin Pharmacokinet 2011; 50(6): 349-69.
[http://dx.doi.org/10.2165/11586800-000000000-00000 ] [PMID: 21553931]
[98]
Ammon HP. Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases. Wien Med Wochenschr 2002; 152(15-16): 373-8.
[http://dx.doi.org/10.1046/j.1563-258X.2002.02056.x ] [PMID: 12244881]
[99]
Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: A double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010; 7(6): 366-77.
[http://dx.doi.org/10.7150/ijms.7.366] [PMID: 21060724]
[100]
Wang H, Zhang C, Wu Y, Ai Y, Lee DYW, Dai R. Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of Boswellia serrata extract or Huo Luo Xiao Ling Dan by LC‐MS. Biomed Chromatogr 2014; 28(10): 1402-8.
[http://dx.doi.org/10.1002/bmc.3182] [PMID: 24806456]
[101]
Sharma ML, Bani S, Singh GB. Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. Int J Immunopharmacol 1989; 11(6): 647-52.
[http://dx.doi.org/10.1016/0192-0561(89)90150-1] [PMID: 2807636]
[102]
Jeong JW, Lee HH, Kim J, et al. Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate-induced osteoarthritis rats. Mol Med Rep 2017; 16(4): 3841-8.
[http://dx.doi.org/10.3892/mmr.2017.7075] [PMID: 29067461]
[103]
Zeng N, Tong B, Zhang X, et al. Antiarthritis effect of morin is associated with inhibition of synovial angiogensis. Drug Dev Res 2015; 76(8): 463-73.
[http://dx.doi.org/10.1002/ddr.21282] [PMID: 26769128]
[104]
Sunil MA, Sunitha VS, Radhakrishnan EK, Jyothis M. Immunomodulatory activities of Acacia catechu, a traditional thirst quencher of South India. J Ayurveda Integr Med 2019; 10(3): 185-91.
[http://dx.doi.org/10.1016/j.jaim.2017.10.010] [PMID: 29502869]
[105]
Kamal E, Kaddam LA, Dahawi M, et al. Gum arabic fibers decreased inflammatory markers and disease severity score among rheumatoid arthritis patients, phase II trial. Int J of Rheumat 2018.
[http://dx.doi.org/10.1155/2018/4197537]
[106]
Nonose N, Pereira JA, Machado PRM, Rodrigues MR, Sato DT, Martinez CAR. Oral administration of curcumin (Curcuma longa) can attenuate the neutrophil inflammatory response in zymosan-induced arthritis in rats. Acta Cir Bras 2014; 29(11): 727-34.
[http://dx.doi.org/10.1590/S0102-86502014001800006 ] [PMID: 25424293]
[107]
Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial. J Diet Suppl 2016; 13(2): 209-20.
[http://dx.doi.org/10.3109/19390211.2015.1008611 ] [PMID: 25688638]
[108]
Chen JJ, Dai L, Zhao LX, Zhu X, Cao S, Gao YJ. Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis. Sci Rep 2015; 5(1): 10278.
[http://dx.doi.org/10.1038/srep10278] [PMID: 25988362]
[109]
Zou S, Wang C, Cui Z, et al. β-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase. Pharmacol Rep 2016; 68(1): 7-11.
[http://dx.doi.org/10.1016/j.pharep.2015.06.004] [PMID: 26721344]
[110]
Sharma S, Arif M, Nirala RK, Gupta R, Thakur SC. Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen‐induced arthritis: Inhibition of both pro‐inflammatory mediators and oxidative stress. J Sci Food Agric 2016; 96(5): 1500-10.
[http://dx.doi.org/10.1002/jsfa.7252] [PMID: 25966322]
[111]
Zgrajka W, Turska M, Rajtar G, Majdan M, Parada-Turska J. Kynurenic acid content in anti-rheumatic herbs. Annal of Agri and Environ Medicin 2013; 20(4)
[112]
Parada-Turska J, Rzeski W, Zgrajka W, Majdan M, Kandefer-Szerszeń M, Turski W. Kynurenic acid, an endogenous constituent of rheumatoid arthritis synovial fluid, inhibits proliferation of synoviocytes in vitro. Rheumatol Int 2006; 26(5): 422-6.
[http://dx.doi.org/10.1007/s00296-005-0057-4] [PMID: 16220290]
[113]
Bonaterra GA, Heinrich EU, Kelber O, Weiser D, Metz J, Kinscherf R. Anti-inflammatory effects of the willow bark extract STW 33-I (Proaktiv®) in LPS-activated human monocytes and differentiated macrophages. Phytomedicine 2010; 17(14): 1106-13.
[http://dx.doi.org/10.1016/j.phymed.2010.03.022] [PMID: 20570123]
[114]
Drummond EM, Harbourne N, Marete E, et al. Inhibition of proinflammatory biomarkers in THP1 macrophages by polyphenols derived from chamomile, meadowsweet and willow bark. Phytother Res 2013; 27(4): 588-94.
[http://dx.doi.org/10.1002/ptr.4753] [PMID: 22711544]
[115]
Hsu DZ, Chu PY, Jou IM. Daily sesame oil supplement attenuates joint pain by inhibiting muscular oxidative stress in osteoarthritis rat model. J Nutr Biochem 2016; 29: 36-40.
[http://dx.doi.org/10.1016/j.jnutbio.2015.10.007] [PMID: 26895663]
[116]
Hsu DZ, Chen SJ, Chu PY, Liu MY. Therapeutic effects of sesame oil on monosodium urate crystal-induced acute inflammatory response in rats. Springerplus 2013; 2(1): 659.
[http://dx.doi.org/10.1186/2193-1801-2-659] [PMID: 24353977]
[117]
Sotnikova R, Ponist S, Navarova J, et al. Effects of sesame oil in the model of adjuvant arthritis. Neuroendocrinol Lett 2009; 30 (Suppl. 1): 22-4.
[PMID: 20027138]
[118]
Haghighian KM, Alipoor B, Mahdavi MA, et al. Effects of sesame seed supplementation on inflammatory factors and oxidative stress biomarkers in patients with knee osteoarthritis. Acta Med Iran 2015; 53(4): 207-13.
[PMID: 25871017]
[119]
Yashaswini PS, Rao AGA, Singh SA. Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity. Int J Biol Macromol 2017; 94(Pt B): 781-7.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.06.048] [PMID: 27316769]
[120]
Hemshekhar M, Thushara RM, Jnaneshwari S, Devaraja S, Kemparaju K, Girish KS. Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status. Eur J Nutr 2013; 52(7): 1787-99.
[http://dx.doi.org/10.1007/s00394-012-0482-6] [PMID: 23269651]
[121]
Huang SH, Lee CH, Wang HM, et al. 6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages. J Agric Food Chem 2014; 62(37): 9171-9.
[http://dx.doi.org/10.1021/jf501665v] [PMID: 25162585]
[122]
van Breemen RB, Tao Y, Li W. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia 2011; 82(1): 38-43.
[http://dx.doi.org/10.1016/j.fitote.2010.09.004] [PMID: 20837112]
[123]
Ueda H, Ippoushi K, Takeuchi A. Repeated oral administration of a squeezed ginger (Zingiber officinale) extract augmented the serum corticosterone level and had anti-inflammatory properties. Biosci Biotechnol Biochem 2010; 74(11): 2248-52.
[http://dx.doi.org/10.1271/bbb.100456] [PMID: 21071834]
[124]
Naderi Z, Mozaffari-Khosravi H, Dehghan A, Nadjarzadeh A, Huseini HF. Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial. J Tradit Complement Med 2016; 6(3): 199-203.
[http://dx.doi.org/10.1016/j.jtcme.2014.12.007] [PMID: 27419081]
[125]
Lee HY, Park SH, Lee M, et al. 1‐Dehydro‐[10]‐gingerdione from ginger inhibits IKKβ activity for NF‐κB activation and suppresses NF‐κB‐regulated expression of inflammatory genes. Br J Pharmacol 2012; 167(1): 128-40.
[http://dx.doi.org/10.1111/j.1476-5381.2012.01980.x ] [PMID: 22489648]
[126]
Huang THW, Tran VH, Duke RK, et al. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation. J Ethnopharmacol 2006; 104(1-2): 149-55.
[http://dx.doi.org/10.1016/j.jep.2005.08.055] [PMID: 16203115]
[127]
Hiermann A, Writzel M. Antiphlogistic qlycopeptide from the roots of Symphytum officinale. Pharmaceutical and Pharmacological Letters 1998; 8(4): 154-7.
[128]
Gracza L, Koch H, Löffler E. Biochemical-pharmacologic studies of medicinal plants. 1. Isolation of rosmarinic acid from Symphytum officinale L. and its anti-inflammatory activity in an in vitro model. Arch Pharm (Weinheim) 1985; 318(12): 1090-5.
[http://dx.doi.org/10.1002/ardp.19853181207] [PMID: 4096630]
[129]
Gracza L. Prüfung der membranabdichtenden Wirkung eines Phytopharmakons und dessen Wirkstoffe. Z Phytother 1987; 8: 78-81.
[130]
Xu Y, Tan HY, Li S, Wang N, Feng Y. Panax notoginseng for inflammation-related chronic diseases: a review on the modulations of multiple pathways. Am J Chin Med 2018; 46(5): 971-96.
[http://dx.doi.org/10.1142/S0192415X18500519] [PMID: 29976083]
[131]
Chang SH, Choi Y, Park JA, et al. Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model. Clin Nutr 2007; 26(6): 785-91.
[http://dx.doi.org/10.1016/j.clnu.2007.07.008] [PMID: 17933436]
[132]
Chang SH, Sung HC, Choi Y, et al. Suppressive effect of AIF, a water extract from three herbs, on collagen-induced arthritis in mice. Int Immunopharmacol 2005; 5(9): 1365-72.
[http://dx.doi.org/10.1016/j.intimp.2005.02.019] [PMID: 15953563]
[133]
Kshirsagar AD, Panchal PV, Harle UN, Nanda RK, Shaikh HM. Anti-inflammatory and antiarthritic activity of anthraquinone derivatives in rodents. Int J of Inflam 2014.
[http://dx.doi.org/10.1155/2014/690596]
[134]
Ghavipour M, Sotoudeh G, Tavakoli E, Mowla K, Hasanzadeh J, Mazloom Z. Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients. Eur J Clin Nutr 2017; 71(1): 92-6.
[http://dx.doi.org/10.1038/ejcn.2016.151] [PMID: 27577177]
[135]
Hayden MS, Ghosh S. Signaling to NF-κB. Genes Dev 2004; 18(18): 2195-224.
[http://dx.doi.org/10.1101/gad.1228704] [PMID: 15371334]
[136]
Schieven G. The biology of p38 kinase: A central role in inflammation. Curr Top Med Chem 2005; 5(10): 921-8.
[http://dx.doi.org/10.2174/1568026054985902] [PMID: 16178737]
[137]
Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, Benderdour M. Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. J Cell Biochem 2011; 112(1): 107-17.
[http://dx.doi.org/10.1002/jcb.22884] [PMID: 20872780]
[138]
Wang F, Qiao Y, Niu H, Zhao H. Anti-arthritic effect of total anthraquinone from Polygonum cuspidatum on type II collagen-induced arthritis in rats. Trop J Pharm Res 2017; 16(10): 2453-9.
[http://dx.doi.org/10.4314/tjpr.v16i10.20]
[139]
Geng Q, Wei Q, Wang S, et al. Physcion 8-O-β-glucopyranoside extracted from Polygonum cuspidatum exhibits anti-proliferative and anti-inflammatory effects on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through the TGF-β/MAPK pathway. Int J Mol Med 2018; 42(2): 745-54.
[PMID: 29717774]
[140]
Kawaguchi K, Maruyama H, Kometani T, Kumazawa Y. Suppression of collagen-induced arthritis by oral administration of the citrus flavonoid hesperidin. Planta Med 2006; 72(5): 477-9.
[http://dx.doi.org/10.1055/s-2005-916254] [PMID: 16557465]
[141]
Nair V, Singh S, Gupta YK. Evaluation of the disease modifying activity of Colchicum luteum Baker in experimental arthritis. J Ethnopharmacol 2011; 133(2): 303-7.
[http://dx.doi.org/10.1016/j.jep.2010.09.027] [PMID: 20920569]
[142]
Adegbehingbe OO, Adesanya SA, Idowu TO, Okimi OC, Oyelami OA, Iwalewa EO. Clinical effects of Garcinia kola in knee osteoarthritis. J Orthop Surg Res 2008; 3(1): 34.
[http://dx.doi.org/10.1186/1749-799X-3-34] [PMID: 18667082]
[143]
Adaramoye OA, Nwaneri VO, Anyanwu KC, Farombi EO, Emerole GO. Possible anti‐atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats. Clin Exp Pharmacol Physiol 2005; 32(1-2): 40-6.
[http://dx.doi.org/10.1111/j.1440-1681.2005.04146.x ] [PMID: 15730433]
[144]
Wang WJ, Wang PX, Li XJ. The effect of sinomenine on cyclooxygenase activity and the expression of COX-1 and COX-2 mRNA in human peripheral monocytes. Zhongguo Zhongyao Zazhi 2003; 28(4): 352-5.
[PMID: 15139149]
[145]
Zou TX, Zhang YG, Zhang HG. Effects of sinomenine on phagocytosis ability of macrophage. Pharmacol Clin Chin Mater Med 2008; 24: 15-7.
[146]
Sharma S, Gupta R, Thakur SC. Attenuation of collagen induced arthritis by Centella asiatica methanol fraction via modulation of cytokines and oxidative stress. Biomed Environ Sci 2014; 27(12): 926-38.
[PMID: 25484009]
[147]
Park JS, Park MK, Oh HJ, et al. Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis. PLoS One 2012; 7(12): e51377.
[http://dx.doi.org/10.1371/journal.pone.0051377] [PMID: 23251512]
[148]
Muniandy K, Gothai S, Badran KM, Kumar S, Esa NM, Arulselvan P. Suppression of proinflammatory cytokines and mediators in LPS-induced RAW 264.7 macrophages by stem extract of Alternanthera sessilis via the inhibition of the NF-κB pathways. J of Immunol Resear 2018; 2018.
[149]
Seo JB, Jeong JY, Park JY, et al. Anti-arthritic and analgesic effect of NDI10218, a standardized extract of Terminalia chebula, on arthritis and pain model. Biomol Ther (Seoul) 2012; 20(1): 104-12.
[http://dx.doi.org/10.4062/biomolther.2012.20.1.104 ] [PMID: 24116282]
[150]
Bang YS, Kim JH, Kim HY, et al. Achyranthes japonica exhibits anti-inflammatory effect via NF-κB suppression and HO-1 induction in macrophages. J Ethnopharmacol 2012; 144(1): 109-17.
[http://dx.doi.org/10.1016/j.jep.2012.08.037] [PMID: 22974544]
[151]
Jung HW, Jung JK, Son KH, et al. Inhibitory effects of the root extract of Dipsacus asperoides C.Y. Cheng et al T.M.Ai on collagen-induced arthritis in mice. J Ethnopharmacol 2012; 139(1): 98-103.
[http://dx.doi.org/10.1016/j.jep.2011.10.020] [PMID: 22041103]
[152]
Zheng W, Lu X, Fu Z, et al. Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis. Biochim Biophys Acta Proteins Proteomics 2016; 1864(3): 308-16.
[http://dx.doi.org/10.1016/j.bbapap.2015.12.010] [PMID: 26724776]
[153]
Channa S, Dar A, Anjum S, Yaqoob M, Atta-ur-Rahman . Anti-inflammatory activity of Bacopa monniera in rodents. J Ethnopharmacol 2006; 104(1-2): 286-9.
[http://dx.doi.org/10.1016/j.jep.2005.10.009] [PMID: 16343831]
[154]
Nemetchek MD, Stierle AA, Stierle DB, Lurie DI. The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. J Ethnopharmacol 2017; 197: 92-100.
[http://dx.doi.org/10.1016/j.jep.2016.07.073] [PMID: 27473605]
[155]
Bhandari P, Kamdod M. Emblica officinalis (Amla): A review of potential therapeutic applications. Int J Green Pharmacy 2012; 6(4): 257.
[http://dx.doi.org/10.4103/0973-8258.108204]
[156]
Penolazzi L, Lampronti I, Borgatti M, et al. Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis. BMC Complement Altern Med 2008; 8(1): 59.
[http://dx.doi.org/10.1186/1472-6882-8-59] [PMID: 18973662]
[157]
Sannegowda KM, Venkatesha SH, Moudgil KD. Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage. Int J Immunopathol Pharmacol 2015; 28(4): 521-31.
[http://dx.doi.org/10.1177/0394632015608248] [PMID: 26467057]
[158]
Chi S, She G, Han D, Wang W, Liu Z, Liu B. Genus Tinospora: ethnopharmacology, phytochemistry, and pharmacology. Evidence-Based Complement Altern Med 2016.
[159]
Nisar A, Akhter N, Singh G, et al. Modulation of T-helper cytokines and inflammatory mediators by Atropa accuminata. Royle in adjuvant induced arthritic tissues. J Ethnopharmacol 2015; 162: 215-24.
[http://dx.doi.org/10.1016/j.jep.2014.08.008] [PMID: 25476486]
[160]
Mehmood A, Malik A, Anis I, et al. Highly oxygenated triterpenes from the roots of Atropa acuminata. Nat Prod Lett 2002; 16(6): 371-6.
[http://dx.doi.org/10.1080/10575630290033097] [PMID: 12462340]
[161]
Eric GB, Lawrence JL. Rheumatoid Arthritis and Its Therapy—The Text Book of Therapeutics: Drug and Disease Management. (16th ed.). Baltimore, Md, USA: Williams and Wilkins Company 1996; Vol. 16.
[162]
Foster S. Gymnema sylvestre. Alternative Medicine Reviews Monographs 2002; pp. 205-7.
[163]
Park YJ, Cho YR, Oh JS, Ahn EK. Effects of Tribulus terrestris on monosodium iodoacetate-induced osteoarthritis pain in rats. Mol Med Rep 2017; 16(4): 5303-11.
[http://dx.doi.org/10.3892/mmr.2017.7296] [PMID: 28849084]
[164]
Wu TS, Shi LS, Kuo SC. Alkaloids and other constituents from Tribulus terrestris. Phytochemistry 1999; 50(8): 1411-5.
[http://dx.doi.org/10.1016/S0031-9422(97)01086-8]
[165]
Kumar KS, Vijayan V, Bhaskar S, Krishnan K, Shalini V, Helen A. Anti-inflammatory potential of an ethyl acetate fraction isolated from Justicia gendarussa roots through inhibition of iNOS and COX-2 expression via NF-κB pathway. Cell Immunol 2012; 272(2): 283-9.
[http://dx.doi.org/10.1016/j.cellimm.2011.09.014] [PMID: 22063737]
[166]
Kiren Y, Deguchi J, Hirasawa Y, Morita H, Prajogo B. Justidrusamides A–D, new 2-aminobenzyl alcohol derivatives from Justicia gendarussa. J Nat Med 2014; 68(4): 754-8.
[http://dx.doi.org/10.1007/s11418-014-0862-8] [PMID: 25099953]
[167]
Uroos M, Abbas Z, Sattar S, Umer N, Shabbir A, Sharif A. Nyctanthes arbor-tristis ameliorated FCA-induced experimental arthritis: A comparative study among different extracts. Evid-Based Compl Alt Med 2017.
[168]
Nagatoshi M, Terasaka K, Nagatsu A, Mizukami H. Iridoid-specific glucosyltransferase from Gardenia jasminoides. J Biol Chem 2011; 286(37): 32866-74.
[http://dx.doi.org/10.1074/jbc.M111.242586] [PMID: 21799001]
[169]
Viljoen A, Mncwangi N, Vermaak I. Anti-inflammatory iridoids of botanical origin. Curr Med Chem 2012; 19(14): 2104-27.
[http://dx.doi.org/10.2174/092986712800229005] [PMID: 22414102]
[170]
Lad H, Bhatnagar D. Amelioration of oxidative and inflammatory changes by Swertia chirayita leaves in experimental arthritis. Inflammopharmacology 2016; 24(6): 363-75.
[http://dx.doi.org/10.1007/s10787-016-0290-3] [PMID: 27738917]
[171]
Kumar IVMLR, Paul BN, Asthana R, Saxena A, Mehrotra S, Rajan G. Swertia chirayita mediated modulation of interleukin-1β, interleukin-6, interleukin-10, interferon-γ, and tumor necrosis factor-α in arthritic mice. Immunopharmacol Immunotoxicol 2003; 25(4): 573-83.
[http://dx.doi.org/10.1081/IPH-120026442] [PMID: 14686799]
[172]
Sylvester J, Liacini A, Li WQ, Dehnade F, Zafarullah M. Tripterygium wilfordii Hook F extract suppresses proinflammatory cytokine-induced expression of matrix metalloproteinase genes in articular chondrocytes by inhibiting activating protein-1 and nuclear factor-kappaB activities. Mol Pharmacol 2001; 59(5): 1196-205.
[http://dx.doi.org/10.1124/mol.59.5.1196] [PMID: 11306704]
[173]
Tong Y, Zhang X, Zhao W, et al. Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis. Eur J Pharmacol 2004; 494(2-3): 101-9.
[http://dx.doi.org/10.1016/j.ejphar.2004.04.053] [PMID: 15212963]
[174]
Lipsky P, Tao X. A potential new treatment for rheumatoid arthritis: Thunder god vine. Semin Arthritis Rheum 1997; 26(5): 713-23.
[http://dx.doi.org/10.1016/S0049-0172(97)80040-6] [PMID: 9144848]
[175]
Kong X, Zhang Y, Liu C, et al. Anti-angiogenic effect of triptolide in rheumatoid arthritis by targeting angiogenic cascade. PLoS One 2013; 8(10): e77513.
[http://dx.doi.org/10.1371/journal.pone.0077513] [PMID: 24204851]
[176]
Rathore B, Jaggi K, Thakur SK, Mathur A, Mahdi F. Anti-inflammatory activity of Crocus sativus extract in experimental arthritis. Int J Pharm Sci Res 2015; 6(4): 1473.
[177]
Li Y, Kakkar R, Wang J. In vivo and in vitro approach to anti-arthritic and anti-inflammatory effect of crocetin by alteration of nuclear factor-E2-related factor 2/hem oxygenase (HO)-1 and NF-κB expression. Front Pharmacol 2018; 9: 1341.
[http://dx.doi.org/10.3389/fphar.2018.01341] [PMID: 30618728]
[178]
Agarwal RB, Rangari VD. Antiinflammatory and antiarthritic activities of lupeol and 19 alpha-H lupeol isolated from Strobilanthus callosus and Strobilanthus ixiocephala roots. Int J Pharmacol 2003; 35(6): 384-7.
[179]
Li XX, Du FY, Liu HX, Ji JB, Xing J. Investigation of the active components in Tripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity. J Ethnopharmacol 2015; 162: 238-43.
[http://dx.doi.org/10.1016/j.jep.2015.01.004] [PMID: 25582490]
[180]
Dudics S, Langan D, Meka R, et al. Natural products for the treatment of autoimmune arthritis: Their mechanisms of action, targeted delivery, and interplay with the host microbiome. Int J Mol Sci 2018; 19(9): 2508.
[http://dx.doi.org/10.3390/ijms19092508] [PMID: 30149545]
[181]
Tao X, Davis LS, Lipsky PE. Effect of an extract of the Chinese herbal remedy Tripterygium wilfordii Hook F on human immune responsiveness. Arthritis Rheum 1991; 34(10): 1274-81.
[http://dx.doi.org/10.1002/art.1780341011] [PMID: 1930317]
[182]
Tao X, Davis LS, Hashimoto K, Lipsky PE. The Chinese herbal remedy, T2, inhibits mitogen-induced cytokine gene transcription by T cells, but not initial signal transduction. J Pharmacol Exp Ther 1996; 276(1): 316-25.
[PMID: 8558449]
[183]
Cabrera C, Artacho R, Giménez R. Beneficial effects of green tea a review. J Am Coll Nutr 2006; 25(2): 79-99.
[http://dx.doi.org/10.1080/07315724.2006.10719518 ] [PMID: 16582024]
[184]
Singh R, Akhtar N, Haqqi TM. Green tea polyphenol epigallocatechi3-gallate: Inflammation and arthritis. Life Sci 2010; 86(25-26): 907-18.
[http://dx.doi.org/10.1016/j.lfs.2010.04.013] [PMID: 20462508]
[185]
Akhtar N, Haqqi TM. Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes. Arthritis Res Ther 2011; 13(3): R93.
[http://dx.doi.org/10.1186/ar3368] [PMID: 21682898]
[186]
Hussain SF, Khan L, Sadozai KK, Shamma M. New alkaloids from Berberis orthobotrys. J Nat Prod 1981; 44(3): 274-8.
[http://dx.doi.org/10.1021/np50015a006]
[187]
Wang Z, Chen Z, Yang S, et al. Berberine ameliorates collagen-induced arthritis in rats associated with anti-inflammatory and anti-angiogenic effects. Inflammation 2014; 37(5): 1789-98.
[http://dx.doi.org/10.1007/s10753-014-9909-y] [PMID: 24803296]
[188]
Yang Y, Qi J, Wang Q, et al. Berberine suppresses Th17 and dendritic cell responses. Invest Ophthalmol Vis Sci 2013; 54(4): 2516-22.
[http://dx.doi.org/10.1167/iovs.12-11217] [PMID: 23482469]
[189]
Chatterjee GK, Pal SP. Search for anti-inflammatory agents from Indian medicinal plants: A review. IDrugs 1984; 21: 413.
[190]
Ren Y, Lu L, Guo TB, et al. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. J Immunol 2008; 181(2): 1491-8.
[http://dx.doi.org/10.4049/jimmunol.181.2.1491] [PMID: 18606704]
[191]
Nho JH, Lee HJ, Jung HK, et al. Effect of Saururus chinensis leaves extract on type II collagen-induced arthritis mouse model. BMC Complement Altern Med 2019; 19(1): 2.
[http://dx.doi.org/10.1186/s12906-018-2418-z] [PMID: 30606189]
[192]
Jung SM, Lee J, Lee J, Baek SY, Park SH, Kwok SK. The therapeutic effect of sauchinone on inflammatory arthritis in mice. J Rheum Dis 2016; 23(3): 161-73.
[http://dx.doi.org/10.4078/jrd.2016.23.3.161]
[193]
Hsiao HB, Wu JB, Lin H, Lin WC. Kinsenoside isolated from Anoectochilus formosanus suppresses LPS-stimulated inflammatory reactions in macrophages and endotoxin shock in mice. Shock 2011; 35(2): 184-90.
[http://dx.doi.org/10.1097/SHK.0b013e3181f0e7a3 ] [PMID: 20661184]
[194]
Qi C, Zhou Q, Yuan Z, et al. Kinsenoside: a promising bioactive compound from Anoectochilus species. Curr Med Sci 2018; 38(1): 11-8.
[http://dx.doi.org/10.1007/s11596-018-1841-1] [PMID: 30074146]
[195]
Yang YC, Lee HS, Lee SH, Clark JM, Ahn YJ. Ovicidal and adulticidal activities of Cinnamomum zeylanicum bark essential oil compounds and related compounds against Pediculus humanus capitis (Anoplura: Pediculicidae). Int J Parasitol 2005; 35(14): 1595-600.
[http://dx.doi.org/10.1016/j.ijpara.2005.08.005] [PMID: 16188263]
[196]
Vetal S, Bodhankar SL, Mohan V, Thakurdesai PA. Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats. Food Sci Hum Wellness 2013; 2(2): 59-67.
[http://dx.doi.org/10.1016/j.fshw.2013.03.003]
[197]
Joshi K, Awte S, Bhatnagar P, et al. Cinnamomum zeylanicum extract inhibits proinflammatory cytokine TNF∝: in vitro and in vivo studies. Res Pharm Biotechnol 2010; 2(2): 14-21.
[198]
Rathi B, Bodhankar S, Mohan V, Thakurdesai P. Ameliorative effects of a polyphenolic fraction of Cinnamomum zeylanicum L. bark in animal models of inflammation and arthritis. Sci Pharm 2013; 81(2): 567-89.
[http://dx.doi.org/10.3797/scipharm.1301-16] [PMID: 23833722]
[199]
Hsiao HB, Wu JB, Lin WC. Anti-arthritic and anti-inflammatory effects of (−)-Epicatechin-3-O-β-d-allopyranoside, a constituent of Davallia formosana. Phytomedicine 2019; 52: 12-22.
[http://dx.doi.org/10.1016/j.phymed.2018.09.192] [PMID: 30599891]
[200]
Lin TH, Yang RS, Wang KC, et al. Ethanol extracts of fresh Davallia formosana (WL1101) inhibit osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation. Evidence-Based Com Alt Medicine 2013.
[201]
Hadi V, Kheirouri S, Alizadeh M, Khabbazi A, Hosseini H. Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Avicenna J Phytomed 2016; 6(1): 34-43.
[PMID: 27247920]
[202]
Shuid AN, Mohamed N, Mohamed IN, et al. Nigella sativa: A potential antiosteoporotic agent. Evid-Based Com Alt Medicine 2012.
[203]
Scotece M, Gómez R, Conde J, et al. Further evidence for the anti-inflammatory activity of oleocanthal: Inhibition of MIP-1α and IL-6 in J774 macrophages and in ATDC5 chondrocytes. Life Sci 2012; 91(23-24): 1229-35.
[http://dx.doi.org/10.1016/j.lfs.2012.09.012] [PMID: 23044226]
[204]
Mével E, Merceron C, Vinatier C, et al. Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption. Sci Rep 2016; 6(1): 33527.
[http://dx.doi.org/10.1038/srep33527] [PMID: 27640363]
[205]
Rosillo MA, Sánchez-Hidalgo M, González-Benjumea A, Fernández-Bolaños JG, Lubberts E, Alarcón-de-la-Lastra C. Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis. Mol Nutr Food Res 2015; 59(12): 2537-46.
[http://dx.doi.org/10.1002/mnfr.201500304] [PMID: 26382723]
[206]
St-Laurent-Thibault C, Arseneault M, Longpré F, Ramassamy C. Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling. Curr Alzheimer Res 2011; 8(5): 543-51.
[http://dx.doi.org/10.2174/156720511796391845] [PMID: 21605049]
[207]
Beauchamp GK, Keast RSJ, Morel D, et al. Ibuprofen-like activity in extra-virgin olive oil. Nature 2005; 437(7055): 45-6.
[http://dx.doi.org/10.1038/437045a] [PMID: 16136122]
[208]
Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci 2004; 1030(1): 434-41.
[http://dx.doi.org/10.1196/annals.1329.054] [PMID: 15659827]
[209]
Keiss HP, Dirsch VM, Vollmar AM, et al. Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity. J Nutr 2003; 133(7): 2171-5.
[http://dx.doi.org/10.1093/jn/133.7.2171] [PMID: 12840173]
[210]
Lee HS, Lee CH, Tsai HC, Salter DM. Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1β. Osteoarthritis Cartilage 2009; 17(1): 91-9.
[http://dx.doi.org/10.1016/j.joca.2008.05.010] [PMID: 18573668]
[211]
Shi L, Lin Q, Li X, et al. Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation. Mol Nutr Food Res 2017; 61(9): 1601013.
[http://dx.doi.org/10.1002/mnfr.201601013] [PMID: 28371322]
[212]
Moutia M, Seghrouchni F, Abouelazz O, et al. Allium sativum L. regulates in vitro IL-17 gene expression in human peripheral blood mononuclear cells. BMC Complement Altern Med 2016; 16(1): 377.
[http://dx.doi.org/10.1186/s12906-016-1365-9] [PMID: 27681382]
[213]
Moosavian SP, Paknahad Z, Habibagahi Z, Maracy M. The effects of garlic (Allium sativum) supplementation on inflammatory biomarkers, fatigue, and clinical symptoms in patients with active rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled trial. Phytother Res 2020; 34(11): 2953-62.
[http://dx.doi.org/10.1002/ptr.6723] [PMID: 32478922]
[214]
Gu Y, Fan W, Yin G. The study of mechanisms of protective effect of rg1 against arthritis by inhibiting osteoclast differentiation and maturation in cia mice. Med of Inflammat 2014; 2014.
[http://dx.doi.org/10.1155/2014/305071]
[215]
Kim DH, Chung JH, Yoon JS, et al. Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver. J Ginseng Res 2013; 37(1): 54-63.
[http://dx.doi.org/10.5142/jgr.2013.37.54] [PMID: 23717157]
[216]
Hartung EF. History of the use of colchicum and related medicaments in gout; with suggestions for further research. Ann Rheum Dis 1954; 13(3): 190-200.
[http://dx.doi.org/10.1136/ard.13.3.190] [PMID: 13198053]
[217]
Li Z, Davis GS, Mohr C, Nain M, Gemsa D. Inhibition of LPS-induced tumor necrosis factor-α production by colchicine and other microtubule disrupting drugs. Immunobiology 1996; 195(4-5): 624-39.
[http://dx.doi.org/10.1016/S0171-2985(96)80027-1] [PMID: 8933162]
[218]
Rojas-Duran R, González-Aspajo G, Ruiz-Martel C, et al. Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. J Ethnopharmacol 2012; 143(3): 801-4.
[http://dx.doi.org/10.1016/j.jep.2012.07.015] [PMID: 22846434]
[219]
Venkatesha SH, Dudics S, Astry B, Moudgil KD. Control of autoimmune inflammation by celastrol, a natural triterpenoid. Pathog Dis 2016; 74(6): ftw059.
[http://dx.doi.org/10.1093/femspd/ftw059] [PMID: 27405485]
[220]
Jing R, Ban Y, Xu W, et al. Therapeutic effects of the total lignans from Vitex negundo seeds on collagen-induced arthritis in rats. Phytomedicine 2019; 58152825.
[http://dx.doi.org/10.1016/j.phymed.2019.152825] [PMID: 30831463]
[221]
Khan MA, Ahmed RS, Chandra N, Arora VK, Ali A. In vivo, extract from Withania somnifera root ameliorates arthritis via regulation of key immune mediators of inflammation in experimental model of arthritis. Antiinflamm Antiallergy Agents Med Chem 2019; 18(1): 55-70.
[http://dx.doi.org/10.2174/1871523017666181116092934] [PMID: 30444203]
[222]
Kimura I, Yoshikawa M, Kobayashi S, et al. New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice. Bioorg Med Chem Lett 2001; 11(8): 985-9.
[http://dx.doi.org/10.1016/S0960-894X(01)00111-1] [PMID: 11327606]
[223]
Karan M, Kumar V, Suneja V, Vasisht K. Commercial herbal anti-inflammatory formulations- a survey. Pharmacos 2009; 36: 14-25.
[224]
Karan M, Sarup P, Suneja V, Vasisht K. Effect of traditional Ayurvedic purification processes (Sodhanvidhi) of Guggulu on carrageenan-induced paw oedema in rats. J Pharm Biomed Sci 2012; 21: 1-5.
[225]
Khanna D, Sethi G, Ahn K, et al. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol 2007; 7(3): 344-51.
[http://dx.doi.org/10.1016/j.coph.2007.03.002] [PMID: 17475558]
[226]
Sarup P, Bala S, Kamboj S. Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora wightii (Guggulu). Scientifica (Cairo) 2015; 2015: 1-14.
[http://dx.doi.org/10.1155/2015/138039] [PMID: 26587309]
[227]
Matsuda H, Morikawa T, Ando S, et al. Absolute stereostructures of polypodane- and octanordammarane-type triterpenes with nitric oxide production inhibitory activity from guggul-gum resins. Bioorg Med Chem 2004; 12(11): 3037-46.
[http://dx.doi.org/10.1016/j.bmc.2004.03.020] [PMID: 15142562]
[228]
Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci 2011; 73(3): 255-61.
[PMID: 22457547]
[229]
Powar V, Jayaprakash G, Jadhav L, Sreedevi KS, Bhatt R. Vatari guggulu and mahaushadhi kwatha in amavata (Rheumatoid Arthritis): An open-label, single-arm clinical study. J Ayurveda 2022; 16(4): 280-92.
[http://dx.doi.org/10.4103/joa.joa_157_21]
[230]
Singh VS, Dhawale SC, Shakeel F, Faiyazuddin M, Alshehri S. Antiarthritic Potential of Calotropis procera leaf fractions in FCA-induced arthritic rats: Involvement of cellular inflammatory mediators and other biomarkers. Agriculture 2021; 11(1): 68.
[http://dx.doi.org/10.3390/agriculture11010068]
[231]
Paul S, Modak D, Chattaraj S, et al. Aloe vera gel homogenate shows anti-inflammatory activity through lysosomal membrane stabilization and downregulation of TNF-α and Cox-2 gene expressions in inflammatory arthritic animals. Fut J Pharm Sci 2021; 7(1): 12.
[http://dx.doi.org/10.1186/s43094-020-00163-6]
[232]
Dong X, Fu J, Yin X, et al. Huyiligeqi, Ni J. Emodin: A review of its pharmacology, toxicity and pharmacokinetics. Phytother Res 2016; 30(8): 1207-18.
[http://dx.doi.org/10.1002/ptr.5631] [PMID: 27188216]
[233]
Wang B, Chen MZ. Astragaloside IV possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage. Arch Pharm Res 2014; 37(6): 793-802.
[http://dx.doi.org/10.1007/s12272-014-0336-2] [PMID: 24469603]
[234]
Qi Y, Gao F, Hou L, Wan C. Anti-inflammatory and immunostimulatory activities of astragalosides. Am J Chin Med 2017; 45(6): 1157-67.
[http://dx.doi.org/10.1142/S0192415X1750063X] [PMID: 28830214]
[235]
Mobasheri A, Henrotin Y, Biesalski HK, Shakibaei M. Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci 2012; 13(4): 4202-32.
[http://dx.doi.org/10.3390/ijms13044202] [PMID: 22605974]
[236]
Makuch S, Więcek K, Woźniak M. The immunomodulatory and anti-inflammatory effect of curcumin on immune cell populations, cytokines, and in vivo models of rheumatoid arthritis. Pharmaceuticals (Basel) 2021; 14(4): 309.
[http://dx.doi.org/10.3390/ph14040309] [PMID: 33915757]
[237]
Zhang N, Liu Z, Luo H, et al. FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways. Biosci Rep 2019; 39(9): BSR20182263.
[http://dx.doi.org/10.1042/BSR20182263] [PMID: 31431516]
[238]
Yan F, Li H, Zhong Z, et al. Co-delivery of prednisolone and curcumin in human serum albumin nanoparticles for effective treatment of rheumatoid arthritis. Int J Nanomedicine 2019; 14: 9113-25.
[http://dx.doi.org/10.2147/IJN.S219413] [PMID: 31819422]
[239]
Manca ML, Lattuada D, Valenti D, et al. Potential therapeutic effect of curcumin loaded hyalurosomes against inflammatory and oxidative processes involved in the pathogenesis of rheumatoid arthritis: The use of fibroblast-like synovial cells cultured in synovial fluid. Eur J Pharm Biopharm 2019; 136: 84-92.
[http://dx.doi.org/10.1016/j.ejpb.2019.01.012] [PMID: 30659893]
[240]
Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A. Immune modulation by curcumin: The role of interleukin-10. Crit Rev Food Sci Nutr 2019; 59(1): 89-101.
[http://dx.doi.org/10.1080/10408398.2017.1358139 ] [PMID: 28799796]
[241]
Stewart CA, Metheny H, Iida N, et al. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest 2013; 123(11): 4859-74.
[http://dx.doi.org/10.1172/JCI65180] [PMID: 24216477]
[242]
Hovsepian E, Penas F, Siffo S, Mirkin GA, Goren NB. IL-10 inhibits the NF-κB and ERK/MAPK-mediated production of pro-inflammatory mediators by up-regulation of SOCS-3 in Trypanosoma cruzi-infected cardiomyocytes. PLoS One 2013; 8(11): e79445.
[http://dx.doi.org/10.1371/journal.pone.0079445] [PMID: 24260222]
[243]
Kobayashi T, Hashimoto S, Horie T. Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Biochem Pharmacol 1997; 54(7): 819-24.
[http://dx.doi.org/10.1016/S0006-2952(97)00220-7] [PMID: 9353136]
[244]
Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Thomas P, Dannenberg AJ. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes. Am J Physiol Gastrointest Liver Physiol 2003; 284(2): G321-7.
[http://dx.doi.org/10.1152/ajpgi.00230.2002] [PMID: 12388178]
[245]
Sánchez-Calvo JM, Villegas I, Sánchez-Fidalgo S, et al. Protective effect of curcumin, a Curcuma longa constituent, in early colonic inflammation in rats. Drug Dev Res 2009; 70(6): 425-37.
[http://dx.doi.org/10.1002/ddr.20319]
[246]
Padmaja S, Raju TN. Antioxidant effect of curcumin in selenium induced cataract of Wistar rats. Indian J Exp Biol 2004; 42(6): 601-3.
[PMID: 15260112]
[247]
Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets 2011; 12(3): 332-47.
[http://dx.doi.org/10.2174/138945011794815356] [PMID: 20955148]
[248]
Pourhabibi-Zarandi F, Rafraf M, Zayeni H, Asghari-Jafarabadi M, Ebrahimi AA. Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled clinical trial. Phytother Res 2022; 36(4): 1797-806.
[http://dx.doi.org/10.1002/ptr.7422] [PMID: 35178811]
[249]
Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids 2002; 67(6): 475-8.
[http://dx.doi.org/10.1054/plef.2002.0441] [PMID: 12468270]
[250]
Al-Nahain A, Jahan R, Rahmatullah M. Zingiber officinale: A potential plant against rheumatoid arthritis. arthritis (Egypt) 2014; 2014: 1-8.
[http://dx.doi.org/10.1155/2014/159089] [PMID: 24982806]
[251]
Aryaeian N, Shahram F, Mahmoudi M, et al. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis. Gene 2019; 698: 179-85.
[http://dx.doi.org/10.1016/j.gene.2019.01.048] [PMID: 30844477]
[252]
Grzanna R, Lindmark L, Frondoza CG. Ginger-an herbal medicinal product with broad anti-inflammatory actions. J Med Food 2005; 8(2): 125-32.
[http://dx.doi.org/10.1089/jmf.2005.8.125] [PMID: 16117603]
[253]
Nurtjahja-Tjendraputra E, Ammit AJ, Roufogalis BD, Tran VH, Duke CC. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res 2003; 111(4-5): 259-65.
[http://dx.doi.org/10.1016/j.thromres.2003.09.009] [PMID: 14693173]
[254]
Lee TY, Lee KC, Chen SY, Chang HH. 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-α and NF-κB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochem Biophys Res Commun 2009; 382(1): 134-9.
[http://dx.doi.org/10.1016/j.bbrc.2009.02.160] [PMID: 19268427]
[255]
Aryaeian N, Mahmoudi M, Shahram F, Poursani S, Jamshidi F, Tavakoli H. The effect of ginger supplementation on IL2, TNFα, and IL1β cytokines gene expression levels in patients with active rheumatoid arthritis: A randomized controlled trial. Med J Islam Repub Iran 2019; 33: 154.
[http://dx.doi.org/10.47176/mjiri.33.154] [PMID: 32280660]
[256]
Suresh P, Kavitha CN, Babu SM, Reddy VP, Latha AK. Effect of ethanol extract of Trigonella foenum graecum (Fenugreek) seeds on Freund’s adjuvant-induced arthritis in albino rats. Inflammation 2012; 35(4): 1314-21.
[http://dx.doi.org/10.1007/s10753-012-9444-7] [PMID: 22395729]
[257]
Kawabata T, Cui MY, Hasegawa T, Takano F, Ohta T. Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from Fenugreek (Trigonella foenum-graecum L.) seeds. Planta Med 2011; 77(7): 705-10.
[http://dx.doi.org/10.1055/s-0030-1250477] [PMID: 20979021]
[258]
Liu Y, Kakani R, Nair MG. Compounds in functional food fenugreek spice exhibit anti-inflammatory and antioxidant activities. Food Chem 2012; 131(4): 1187-92.
[http://dx.doi.org/10.1016/j.foodchem.2011.09.102]
[259]
Sindhu G, Ratheesh M, Shyni GL, Nambisan B, Helen A. Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats. Int Immunopharmacol 2012; 12(1): 205-11.
[http://dx.doi.org/10.1016/j.intimp.2011.11.012] [PMID: 22155102]
[260]
Baliga MS, Mane PP, Nallemgera JT, Thilakchand KR, Kalekhan F. Dietary spices in the prevention of rheumatoid arthritis: Past, present, and future. In: Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults. Academic Press 2015; pp. 41-9.
[261]
Tekeoglu I, Dogan A, Ediz L, Budancamanak M, Demirel A. Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother Res 2007; 21(9): 895-7.
[http://dx.doi.org/10.1002/ptr.2143] [PMID: 17562570]
[262]
Wang D, Qiao J, Zhao X, Chen T, Guan D. Thymoquinone inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by suppressing NF-κB and MAPKs signaling pathway. Inflammation 2015; 38(6): 2235-41.
[http://dx.doi.org/10.1007/s10753-015-0206-1] [PMID: 26156811]
[263]
Al-Okbi SY. Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis. Toxicol Ind Health 2014; 30(8): 738-49.
[http://dx.doi.org/10.1177/0748233712462468] [PMID: 23104728]
[264]
Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res 2012; 26(8): 1246-8.
[http://dx.doi.org/10.1002/ptr.3679] [PMID: 22162258]
[265]
Bhardwaj N, Katyal P, Sharma A. Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum. Recent Pat Inflamm Allergy Drug Discov 2014; 8(2): 104-17.
[http://dx.doi.org/10.2174/1872213X08666140619110657] [PMID: 24948193]
[266]
Roy K, Kanwar RK, Kanwar JR. Molecular targets in arthritis and recent trends in nanotherapy. Int J Nanomedicine 2015; 10: 5407-20.
[PMID: 26345140]
[267]
Allawadhi P, Singh V, Govindaraj K, et al. Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis. Carbohydr Polym 2022; 281118923.
[http://dx.doi.org/10.1016/j.carbpol.2021.118923] [PMID: 35074100]
[268]
Yuan L, Pan M, Shi K, et al. Nanocarriers for promoting skin delivery of therapeutic agents. Appl Mater Today 2022; 27101438.
[http://dx.doi.org/10.1016/j.apmt.2022.101438]
[269]
Mueller AJ, Peffers MJ, Proctor CJ, Clegg PD. Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies. J Orthop Res 2017; 35(8): 1573-88.
[http://dx.doi.org/10.1002/jor.23563] [PMID: 28318047]
[270]
Khare B, Shukla TP. A review on polyherbal formulation used in the treatment of rheumatoid arthritis. Int J Adv Sci Res 2022; 13(1): 31-42.
[http://dx.doi.org/10.55218/JASR.202213103]
[271]
DeSmet PAGM. The safety of herbal products. In: Jonas WB, Levin JS, Eds. Essentials of complementary and alternative medicine. Baltimore, MD: Lippincott Williams & Wilkins 1999; pp. 108-47.
[272]
Little C, Parsons T. Herbal therapy for treating rheumatoid arthritis (Cochrane Review) The Cochrane Library, Issue 1. Oxford: Update Software 2002.
[273]
Janakiraman K, Krishnaswami V, Rajendran V, Natesan S, Kandasamy R. Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights. Mater Today Commun 2018; 17: 200-13.
[http://dx.doi.org/10.1016/j.mtcomm.2018.09.011] [PMID: 32289062]
[274]
Sharifi S, Fathi N, Memar MY, et al. Anti‐microbial activity of curcumin nanoformulations: New trends and future perspectives. Phytother Res 2020; 34(8): 1926-46.
[http://dx.doi.org/10.1002/ptr.6658] [PMID: 32166813]
[275]
Soeken KL, Miller SA, Ernst E. Herbal medicines for the treatment of rheumatoid arthritis: A systematic review. Br J Rheumatol 2003; 42(5): 652-9.
[http://dx.doi.org/10.1093/rheumatology/keg183] [PMID: 12709541]
[276]
Bungau S, Vesa CM, Abid A, et al. Withaferin A — A promising phytochemical compound with multiple results in dermatological diseases. Molecules 2021; 26(9): 2407.

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