Title:Bioprospecting of Metabolites from Actinomycetes and their
Applications
Volume: 18
Issue: 4
Author(s): Syed Khalida Izhar, Shareen Fatima Rizvi, Uzma Afaq, Faria Fatima*Saba Siddiqui*
Affiliation:
- Integral Institute of Agricultural
Science and Technology, Integral University, Lucknow, 226026, India
- Integral Institute of Agricultural
Science and Technology, Integral University, Lucknow, 226026, India
Keywords:
Actinomycetes, applications, medicines, secondary metabolites, sustainability, bioprospecting of metabolites.
Abstract: Actinomycetes are present in various terrestrial and aquatic habitats, predominantly
in the soil rhizosphere, encompassing marine and freshwater ecosystems. These
microorganisms exhibit characteristics that resemble both bacteria and fungi. Numerous
actinomycetes exhibit a mycelial existence and undergo significant morphological transformations.
These bacteria are widely recognized as biotechnologically significant microorganisms
utilized for the production of secondary metabolites. In all, over 45% of all
bioactive microbial metabolites are produced by actinomycetes, which are responsible for
producing around 10,000 of them. The majority of actinomycetes exhibit substantial saprophytic
characteristics in their natural environment, enabling them to effectively decompose
a diverse range of plant and animal waste materials during the process of decomposition.
Additionally, these organisms possess a sophisticated secondary metabolic system,
which enables them to synthesize almost two-thirds of all naturally occurring antibiotics.
Moreover, they can create a diverse array of chemical compounds with medical or agricultural
applications, including anticancer, antiparasitic, and antibacterial agents. This review
aims to provide an overview of the prominent biotechnological domains in which
actinobacteria and their metabolites demonstrate noteworthy applicability. The graphical
abstract provides a preview of the primary sections covered in this review. This paper
presents a comprehensive examination of the biotechnological applications and metabolites
of actinobacteria, highlighting their potential for patent innovations.
