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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Mini-Review Article

Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases

Author(s): Xieyin Sun, Zhaoyi Lin, Nuo Xu, Yinqi Chen, Saiyan Bian and Wenjie Zheng*

Volume 19, Issue 10, 2024

Published on: 24 November, 2023

Page: [1293 - 1302] Pages: 10

DOI: 10.2174/011574888X275737231120045815

Price: $65

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Abstract

Mesenchymal stem cells (MSCs) have been identified as potential therapeutics for various diseases. In contrast to other sources of MSCs, dental stem cells (DSCs) have received increased attention due to their high activity and easy accessibility. Among them, dental pulp stem cells (DPSCs) exhibit superior self-renewal, multipotency, immunomodulatory, and regenerative capacities. Following their inspiring performance in animal models and clinical trials, DPSCs show pharmacological potential in regenerative medicine. In this review, we have generalized the sources, heterogeneity, and biological characteristics of DPSCs, as well as compared them with other types of dental stem cells. In addition, we summarized the application of DPSCs in digestive diseases (such as liver, esophageal, and intestinal diseases), highlighting their regenerative and pharmacological potential based on the existing preclinical and clinical evidence. Specifically, DPSCs can be home to injured or inflamed tissues and exert repair and regeneration functions by facilitating immune regulation, anti-inflammation, and directional differentiation. Although DPSCs have a rosy prospect, future studies should handle the underlying drawbacks and pave the way for the identification of DPSCs as novel regenerative medicine.

Keywords: Dental pulp stem cell, pharmacological, digestive diseases, regenerative medicine, mesenchymal stem cells (MSCs), regenerative medicine.

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