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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors

Author(s): Debroop Basu, Riya Pal, Maitrayee Sarkar, Soubhik Barma, Sumit Halder, Harekrishna Roy, Sisir Nandi* and Asmita Samadder*

Volume 23, Issue 30, 2023

Published on: 29 November, 2023

Page: [2877 - 2972] Pages: 96

DOI: 10.2174/0115680266261150231110053650

Price: $65

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Abstract

Receptor tyrosine kinase (RTK) regulates multiple pathways, including Mitogenactivated protein kinases (MAPKs), PI3/AKT, JAK/STAT pathway, etc. which has a significant role in the progression and metastasis of tumor. As RTK activation regulates numerous essential bodily processes, including cell proliferation and division, RTK dysregulation has been identified in many types of cancers. Targeting RTK is a significant challenge in cancer due to the abnormal upregulation and downregulation of RTK receptors subfamily EGFR, FGFR, PDGFR, VEGFR, and HGFR in the progression of cancer, which is governed by multiple RTK receptor signalling pathways and impacts treatment response and disease progression. In this review, an extensive focus has been carried out on the normal and abnormal signalling pathways of EGFR, FGFR, PDGFR, VEGFR, and HGFR and their association with cancer initiation and progression. These are explored as potential therapeutic cancer targets and therefore, the inhibitors were evaluated alone and merged with additional therapies in clinical trials aimed at combating global cancer.

Keywords: RTK, EGFR, FGFR, PDGFR, VEGFR, HGFR, Potential inhibitors, Cancer treatment.

Graphical Abstract
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