Title:Enhanced Solubility and Increased Bioavailability with Engineered
Nanocrystals
Volume: 19
Issue: 6
Author(s): Reetika Sood, Deepali Tomar, Peeyush Kaushik, Prerna Sharma, Nidhi Rani*, Kumar Guarve, Sanchit Dhankhar and Nitika Garg
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab, India
Keywords:
Nanocrystals, solubility, bioavailability, drug delivery, poorly soluble drugs, homogenization.
Abstract: The exploration of nanocrystal technology is currently receiving significant attention in
various fields, including therapeutic formulation, clinical formulation, in-vivo and in-vitro correlation
research, and related investigations. The domain of nanocrystals in pharmaceutical delivery has received
significant interest as a potential solution for the difficulties associated with medications that
have low solubility. The nanocrystals demonstrate promise in improving solubility and bioavailability,
presenting a potential resolution to significant challenges. Significantly, nanocrystals have exhibited
efficacy in the context of oral administration, showcasing prompt absorption due to their quick
breakdown, hence fitting with the requirements of medications that necessitate fast commencement
of action. In addition, the adaptability of drug nanocrystals encompasses several methods of administration,
including oral, parenteral, ophthalmic, cutaneous, pulmonary, and targeted delivery modalities.
The observed consistency can be ascribed to the increased solubility of nanocrystals of the medicine,
which effectively counteracts the influence of food on the absorption of the drug. Surface modification
tactics have a significant influence on insoluble medicines by enhancing hydrophilicity and
reducing plasma protein adsorption on the crystal surface. The surface properties of nanocrystals are
modified through the utilization of specific surfactants and polymers, which are subsequently incorporated
into polymer solutions via high-pressure homogenization procedures. This article encompasses
an examination of the drug distribution mechanism, the nanocrystal formulation technology,
the therapeutic applications, the potential future developments, and the challenges associated with the
solubility and bioavailability of tailored nanocrystals, as discussed in this article. Consequently, it
possesses the capacity to provide guidance for future investigations pertaining to nanocrystal technology.
