Review Article

Splicing DNA Damage Adaptations for the Management of Cancer Cells

Author(s): Arun Kumar Singh, Deepika Yadav and Rishabha Malviya*

Volume 24, Issue 2, 2024

Published on: 13 November, 2023

Page: [135 - 146] Pages: 12

DOI: 10.2174/0115665232258528231018113410

Price: $65

Abstract

Maintaining a tumour cell's resistance to apoptosis (organized cell death) is essential for cancer to metastasize. Signal molecules play a critical function in the tightly regulated apoptotic process. Apoptosis may be triggered by a wide variety of cellular stresses, including DNA damage, but its ultimate goal is always the same: the removal of damaged cells that might otherwise develop into tumours. Many chemotherapy drugs rely on cancer cells being able to undergo apoptosis as a means of killing them. The mechanisms by which DNA-damaging agents trigger apoptosis, the interplay between pro- and apoptosis-inducing signals, and the potential for alteration of these pathways in cancer are the primary topics of this review.

Keywords: Apoptosis, extrinsic pathway, p38 signaling, cancer, DNA damage, genetic therapy.

Graphical Abstract
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