Title:An MRI-only Three-dimensional Cephalometry Protocol based on the
Integrated and Modular Architecture of the Human Head
Volume: 20
Author(s): Xiling Jiang, Jun Pei, Jianwei Liu, Xu Liao and Fucang Jia*
Affiliation:
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Keywords:
MRI-only three-dimensional Cephalometry, 3D image synthesis, MR compose CT, Integrated and modular characteristics, Median sagittal plane, Human head.
Abstract:
Background:
Currently, three-dimensional cephalometry measurements are mainly based on cone beam computed tomography (CBCT), which has limitations of
ionizing radiation, lack of soft tissue information, and lack of standardization of median sagittal plane establishment.
Objectives:
This study investigated magnetic resonance imaging (MRI)-only based 3D cephalometry measurement based on the integrated and modular
characteristics of the human head.
Methods:
Double U-Net CycleGAN was used for CT image synthesis from MRI. This method enabled the synthesis of a CT-like image from MRI and
measurements were made using 3D slicer registration and fusion.
Results:
A protocol for generating and optimizing MRI-based synthetic CT was described and found to meet the precision requirements of 3D head
measurement using MRI midline positioning methods reported in neuroscience to establish the median sagittal plane. An MRI-only reference
frame and coordinate system were established enabling an MRI-only cephalometric analysis protocol that combined the dual advantages of soft
and hard tissue display. The protocol was devised using data from a single volunteer and validation data from a larger sample remains to be
collected.
Conclusion:
The reported method provided a new protocol for MRI-only cephalometric analysis of craniofacial growth and development, malformation
occurrence, treatment planning, and outcomes.
