Title:Recent Patents on Solid Dispersions Emphasize Promising Benefits in
Solubility Enhancement of Poorly Water-soluble Drugs
Volume: 19
Issue: 2
Author(s): Manisha Saini, Shailender Bhatt, Harish Dureja and Neeta Solanki*
Affiliation:
- Faculty of Pharmaceutical Sciences,
Maharshi Dayanand University, Rohtak, India
Keywords:
Solubility, solid dispersion, commercial products, patents, clinical trials, technology.
Abstract:
Background: In the development of drug delivery systems, drugs' solubility remains the
most challenging constraint. Many newly synthesized chemical compounds are available, but they
involve low solubility and poor permeability restrictions. Among various drug delivery systems, the
utilization of solid dispersion technologies has become more focused due to their promising benefits.
Objective: This technology has attracted extensive attention for dissolution rate improvement along
with substantial bioavailability enhancement of poorly water-soluble drug candidates.
Methods: Many approaches have been employed for preparing solid dispersions, such as the melting
method, hot melt extrusion, solvent evaporation process, fusion and kneading method, spray drying
technique, co-grinding and freeze drying, supercritical fluid technology, etc.
Result: A wide variety of hydrophilic and hydrophobic materials are available as carriers, which are
employed in the formulation of solid dispersions. Depending on the carrier characteristics, immediate-
release solid dispersions and/or controlled-release solid dispersions can be formulated. Multiple
hydrophilic materials have been explored for heightening dissolution features with enhanced bioavailability
of poorly water-soluble drug molecules. The availability of commercially available products
further validates the utility of solid dispersion technology in drug delivery systems.
Conclusion: In the current manuscript, an attempt has been made to highlight the comprehensive
development techniques, characterization techniques, recent solid dispersion technologies, clinical
trial studies, and patented technology, along with studies heightening the dissolution behavior of
numerous poorly aqueous soluble drugs. The major stability issues affecting the suitability of solid
dispersions are also discussed.
