Title:Therapeutic Potential and Prospects of L-arginine in Various Diseases and
its Clinical Intervention
Volume: 19
Issue: 5
Author(s): Sushil Giri, Krishna Kumar Varshney and Rajnish Srivastava*
Affiliation:
- Faculty of Pharmacy, Moradabad
Educational Trust Group of Institutions, Moradabad, Uttar Pradesh, India
Keywords:
L-arginin, nitric oxide, polyamines, heart, endothelium, immune system.
Abstract: The goal of this review is to explored the therapeutic application of L-Arginine (L-ARG)
against various pathological illnesses, such as Alzheimer’s disease (AD), Parkinson’s disease (PD),
cardiovascular disorder, mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes
(MELAS), sickle cell anemia, tumour, epilepsy, erectile dysfunction therapy (ED), gestational
hypertension (GH), and menopause issues. L-ARG is an important semi-essential alpha-amino acid
that serves as a natural precursor for the synthesis of nitric oxide (NO). It is generally synthesized
from proteinogenic amino acid proline through glutamine and glutamate. The degradation of L-ARG
is a complex process due to the expression of multiple enzymes in the form of a substrate. The metabolism
of L-ARG takes place in various multiple pathways, such as nitric oxide synthase, Arginine
glycine amidinotransferase, and Arginine decarboxylase which results in the production of a diverse
range of biochemical compounds, such as nitric oxide, polyamines, proline, glutamate, creanine, agmatine
homoarginine, and urea. NO is a highly diffusible free radicle with a regulatory function in
the heart and acts as an important vasodilator in intact endothelium. NO serves as an important neurotransmitter
in the brain and a mediator of host defense in the immune system. L-ARG is also needed
for ammonia detoxification, which is a very toxic chemical to the central nervous system. This review
article focuses on the relevance of L-ARG in the prevention and treatment of a variety of illnesses.
