The Essential Role of Astrocytes in Neurodegeneration and
Neuroprotection

Federico      López Couselo; Julieta      Saba; Lila      Carniglia; Daniela      Durand; Mercedes      Lasaga; Carla      Caruso
doi:10.2174/0118715273269881231012062255
Abstract

Astrocytes are glial cells that perform several fundamental physiological functions within the brain. They can control neuronal activity and levels of ions and neurotransmitters, and release several factors that modulate the brain environment. Over the past few decades, our knowledge of astrocytes and their functions has rapidly evolved. Neurodegenerative diseases are characterized by selective degeneration of neurons, increased glial activation, and glial dysfunction. Given the significant role played by astrocytes, there is growing interest in their potential therapeutic role. However, defining their contribution to neurodegeneration is more complex than was previously thought. This review summarizes the main functions of astrocytes and their involvement in neurodegenerative diseases, highlighting their neurotoxic and neuroprotective ability.
Keywords: Astrocytes, neurodegenerative diseases, glial reactivity, brain homeostasis, neuroprotection, neurotoxicity.
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DOI https://dx.doi.org/10.2174/0118715273269881231012062255	Print ISSN 1871-5273
Publisher Name Bentham Science Publisher	Online ISSN 1996-3181
CNS & Neurological Disorders - Drug Targets

The Essential Role of Astrocytes in Neurodegeneration and Neuroprotection

Abstract

Graphical Abstract

Heart and Brain Axis Targets in CNS Neurological Disorders

Lifestyle Interventions to Prevent and Treat Cognitive Impairment and Dementia

Pathogenic Proteins in Neurodegenerative Diseases: From Mechanisms to Treatment Modalities

Role of glial cells in autism spectrum disorder: Molecular mechanism and therapeutic approaches

CNS & Neurological Disorders - Drug Targets

The Essential Role of Astrocytes in Neurodegeneration and Neuroprotection

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Heart and Brain Axis Targets in CNS Neurological Disorders

Lifestyle Interventions to Prevent and Treat Cognitive Impairment and Dementia

Pathogenic Proteins in Neurodegenerative Diseases: From Mechanisms to Treatment Modalities

Role of glial cells in autism spectrum disorder: Molecular mechanism and therapeutic approaches

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