Title:Articulating the Pharmacological and Nanotechnological Aspects of
Genistein: Current and Future Prospectives
Volume: 25
Issue: 7
Author(s): Keshav Bansal*, Vanshita Singh, Samiksha Mishra and Meenakshi Bajpai
Affiliation:
- Institute of Pharmaceutical Research, GLA University, Mathura, 281406, Uttar Pradesh, India
Keywords:
Genistein, drug delivery, nano-formulations, isoflavone, pharmacological actions, nanocarriers.
Abstract: Throughout the past several centuries, herbal constituents have been the subject of
scientific interest and the latest research into their therapeutic potential is underway. Genistein is
a soy-derived isoflavone found in huge amounts in soy, along with the plants of the Fabaceae
family. Scientific studies have demonstrated the beneficial effects of genistein on various health
conditions. Genistein presents a broad range of pharmacological activities, including anticancer,
neuroprotective, cardioprotective, antiulcer, anti-diabetic, wound healing, anti-bacterial, antiviral,
skin, and radioprotective effects. However, the hydrophobic nature of genistein results in
constrained absorption and restricts its therapeutic potential. In this review, the number of
nanocarriers for genistein delivery has been explored, such as polymeric nanoparticles,
nanostructured lipid carriers, solid lipid nanoparticles, liposomes, micelles, transferosomes, and
nanoemulsions and nanofibers. These nano-formulations of genistein have been utilized as a
potential strategy for various disorders, employing a variety of ex vivo, in vitro, and in vivo models
and various administration routes. This review concluded that genistein is a potential therapeutic
agent for treating various diseases, including cancer, neurodegenerative disorders, cardiovascular
disorders, obesity, diabetes, ulcers, etc., when formulated in suitable nanocarriers.