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Current Neuropharmacology

Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Insights on Natural Products Against Amyotrophic Lateral Sclerosis (ALS)

Author(s): Kadja Luana Chagas Monteiro, Marcone Gomes dos Santos Alcântara, Thiago Mendonça de Aquino and Edeildo Ferreira da Silva-Júnior*

Volume 22, Issue 7, 2024

Published on: 17 October, 2023

Page: [1169 - 1188] Pages: 20

DOI: 10.2174/1570159X22666231016153606

Price: $65

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Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes the death of motor neurons and consequent muscle paralysis. Despite many efforts to address it, current therapy targeting ALS remains limited, increasing the interest in complementary therapies. Over the years, several herbal preparations and medicinal plants have been studied to prevent and treat this disease, which has received remarkable attention due to their blood-brain barrier penetration properties and low toxicity. Thus, this review presents the therapeutic potential of a variety of medicinal herbs and their relationship with ALS and their physiopathological pathways.

Keywords: Central nervous system, reactive oxygen species, ALS, mtDNA, heat shock proteins, medicinal herbs.

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Graphical Abstract

Graphical abstract illustrating key findings of the study

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