Synchronous Double Primary Malignant Tumors and their Possible Shared Genes: A Rare Clinical Entity

Title:Synchronous Double Primary Malignant Tumors and their Possible Shared Genes: A Rare Clinical Entity

Volume: 20

Author(s): Na Hu, Gang Yan, Mao-wen Tang, Yu-hui Wu, Yi-ning Xiang and Ping-gui Lei*

Affiliation:

• Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China

Keywords: Colorectal cancer, Clear cell renal cell carcinoma, Synchronous, ¹⁸F-FDG PET/CT, Contrast-enhanced CT, Bioinformatics analysis.

Abstract:

Objective: This study sought to analyze the ¹⁸F-FDG PET/CT and contrast-enhanced computed tomography (CT) images of synchronous colorectal cancer (CRC) and renal clear cell carcinoma (ccRCC) and identify the shared genes between these two types of cancer through bioinformatic analysis.

Methods: A retrospective analysis was conducted on a patient with synchronous CRC and ccRCC who underwent ¹⁸F-FDG PET/CT and contrast-enhanced CT before treatment. Databases were analyzed to identify differentially expressed genes between CRC and ccRCC, and co-expression genes were extracted for RCC and CRC.

Results: ¹⁸F-FDG PET/CT revealed intense metabolic activity in the primary colorectal lesion (SUVmax 13.2), while a left renal mass (diameter = 35 mm) was observed with no significant uptake. Contrast-enhanced CT during the arterial phase showed heterogeneous intense enhancement of the renal lesion, and the lesion washed out earlier than in the renal cortex in the nephrographic and excretory phases, indicating ccRCC. The histopathological results confirmed synchronous double primary malignant tumors. Our bioinformatic analysis results showed that synchronous occurrence of CRC and ccRCC may correlate with simultaneous expression of Carbonic Anhydrase 9 (CA9), integrin-binding sialoprotein (IBSP), and Fibrinogen γ chain (FGG).

Conclusion: ¹⁸F-FDG PET/CT combined with contrast-enhanced CT is an effective diagnostic tool in evaluating synchronous CRC and RCC. By analyzing this clinical case and conducting bioinformatic analysis, we improved our current understanding of the mechanisms underlying synchronous tumors.

Cite this article as:

Hu Na, Yan Gang, Tang Mao-wen, Wu Yu-hui, Xiang Yi-ning and Lei Ping-gui*, Synchronous Double Primary Malignant Tumors and their Possible Shared Genes: A Rare Clinical Entity, Current Medical Imaging 2024; 20 : e15734056258908 . https://dx.doi.org/10.2174/0115734056258908230920063040