Title:Formulation and Antimicrobial Screening of Tea Tree Oil Gel
Volume: 3
Issue: 1
Author(s): Karan Agrawal, Vibha Kumari, Talever Singh, Devender Pathak and Mayank Kulshreshtha*
Affiliation:
- Rajiv Academy for Pharmacy, Mathura (U.P.), Mathura, India
Keywords:
Tea tree oil gel, acne, minimum inhibitory concentration, skin diseases, Staphylococcus aureus, sebaceous gland.
Abstract:
Objective: An acne is a frequent form of skin condition brought on by an overproduction of
the particular oil “sebum”, which is produced by the sebaceous gland. This oil accumulates in the follicles
and causes the swelling of pores. Many microbial species such as Staphylococcus aureus, Bacillus
subtills, Escherichia coli, Pseudomonas aeruginosa, Aspergillus tubingensis etc. are responsible for
acne directly or indirectly. The aim of this study was to synthesise the herbal gel of tea tree oil obtained
from the plant M.alternifolia.
Material and Methods: The gel was prepared using Carbopol-940 as a gelling agent using the swelling
method and parameters like spreadability, extrudability, pH, etc were also determined. Zone of inhibition
(ZOI) was estimated with renowned standards (Ciprofloxacin and fluconazole).
Results: Studies revealed that the gel was highly effective against the selected species except fungal
strains. ZOI was observed ranging from 1.6 ± 0.01 mm to 14.9 ± 0.43 mm. The maximum ZOI was
observed (14.9 ± 0.43) against Staphylococcus aureus. The physical properties of the gel satisfied the
standard parameters.
Conclusion: The herbal gel was found to be highly promising activity against bacterial species associated
with acne in a concentration-dependent manner, but more research is needed.
