Title:Progress of Cancer Stem Cells in Retinoblastoma
Volume: 19
Issue: 8
Author(s): Nan Wang and Jian-Min Ma*
Affiliation:
- Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital,
Capital Medical University, Beijing, China
Keywords:
Retinoblastoma, cancer stem cells, drug resistance, Wnt pathway, targeted therapy, tumor.
Abstract: The theory of cancer stem cells is a breakthrough discovery that offers exciting possibilities
for comprehending the biological behavior of tumors. More and more evidence suggests that
retinoblastoma cancer stem cells promote tumor growth and are likely to be the origin of tumor
formation, drug resistance, recurrence, and metastasis. At present, some progress has been made
in the verification, biological behavior, and drug resistance mechanism of retinoblastoma cancer
stem cells. This article aims to review the relevant research and explore future development direction.