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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Review Article

Lycopene: A Powerful Nutraceutical with Diversified Health Benefits

Author(s): Jyoti Singh*, Sahibpreet Singh and Disha Arora

Volume 11, Issue 2, 2025

Published on: 05 October, 2023

Page: [13 - 25] Pages: 13

DOI: 10.2174/0122150838253252230920114357

Price: $65

Abstract

Lycopene, a tetraterpene of eight isoprene units belongs to the family of carotenoids, abundantly found in tomatoes and its derivative products. It is non provitamin A carotenoid which is associated with powerful antioxidant action that may trap reactive oxygen species resulting in an increase in the overall antioxidant potential or a reduction in the oxidative damage to proteins, lipids, and DNA, thereby decreasing the oxidative stress. Due to this, the addition of lycopene to the diet is considered to be important. It is used as a food colorant owing to its strong color and non-toxic nature. Recent literature reports have highlighted the significance of lycopene in health. It exhibits many health benefits in ameliorating cancer, inflammation, diabetes mellitus, cardiovascular complications, Parkinson’s disease, Alzheimer’s disease, and hepatic, skin, and bone diseases. In this review, we have summarized the information regarding sources, chemistry, extraction techniques, and health benefits of lycopene.

Keywords: Lycopene, health benefits, carotenoid, chemistry, antioxidant, tomato, food colorant.

[1]
Kumar, V.N.P.; Elango, P.; Asmathulla, S. A systematic review on lycopene and its beneficial effects. Systematic review on lycopene and its beneficial effects. Biomed. Pharmacol. J., 2017, 10(4), 113-20.https://biomedpharmajournal.org/vol10no4/a-systematic-review-onlycopene-and-its-beneficial-effects/
[2]
Setyorini, D. Terpenoids: Lycopene in Tomatoes. In: In: Terpenes and Terpenoids - Recent Advances; Intech Open, 2021.
[3]
Kong, K.W.; Khoo, H.E.; Prasad, K.N.; Ismail, A.; Tan, C.P.; Rajab, N.F. Revealing the power of the natural red pigment lycopene. Molecules, 2010, 15(2), 959-987.
[http://dx.doi.org/10.3390/molecules15020959] [PMID: 20335956]
[4]
Zhang, Q.W.; Lin, L.G.; Ye, W.C. Techniques for extraction and isolation of natural products: A comprehensive review. Chin. Med., 2018, 13(1), 20.
[http://dx.doi.org/10.1186/s13020-018-0177-x] [PMID: 29692864]
[5]
Naz, A.; Butt, M.S.; Sultan, M.T.; Qayyum, M.M.; Niaz, R.S. Watermelon lycopene and allied health claims. EXCLI J., 2014, 13, 650-660.
[PMID: 26417290]
[6]
Chen, D.; Huang, C.; Chen, Z. A review for the pharmacological effect of lycopene in central nervous system disorders. Biomed. Pharmacother., 2019, 111, 791-801.
[http://dx.doi.org/10.1016/j.biopha.2018.12.151] [PMID: 30616078]
[7]
Kirkil, G.; Muz, M.H.; Sancaktar, E.; Kaman, D.; Şahin, K.; Küçük, Ö. The effect of lycopene supplementation on chronic obstructive lung disease. Nobel Med., 2012, 8(3), 98-104.
[8]
Khan, U.M.; Sevindik, M.; Zarrabi, A.; Nami, M.; Ozdemir, B.; Kaplan, D.N.; Selamoglu, Z.; Hasan, M.; Kumar, M.; Alshehri, M.M.; Sharifi-Rad, J. Lycopene: Food sources, biological activities, and human health benefits. Oxid. Med. Cell. Longev., 2021, 2021, 1-10.
[http://dx.doi.org/10.1155/2021/2713511] [PMID: 34840666]
[9]
Arain, M.A.; Mei, Z.; Hassan, F.U.; Saeed, M.; Alagawany, M.; Shar, A.H.; Rajput, I.R. Lycopene: A natural antioxidant for prevention of heat-induced oxidative stress in poultry. Worlds Poult. Sci. J., 2018, 74(1), 89-100.
[http://dx.doi.org/10.1017/S0043933917001040]
[10]
Camara, M.; Sánchez-Mata, M.D.; Fernández-Ruíz, V.; Cámara, R.M.; Manzoor, S.; Caceres, J.O. Lycopene: A review of chemical and biological activity related to beneficial health effects. In: In: Studies in Natural Products Chemistry; Elsevier, 2013; 40, pp. 383-426.https://www.researchgate.net/publication/253802934_Lycopene_A_Review_of_Chemical_and_Biological_Activity_Related_to_Beneficial_Health_Effects
[11]
Grabowska, M.; Wawrzyniak, D.; Rolle, K.; Chomczyński, P.; Oziewicz, S.; Jurga, S.; Barciszewski, J. Let food be your medicine: Nutraceutical properties of lycopene. Food Funct., 2019, 10(6), 3090-3102.
[http://dx.doi.org/10.1039/C9FO00580C] [PMID: 31120074]
[12]
Joshi, B.; Kar, S.K.; Yadav, P.K.; Yadav, S.; Shrestha, L.; Bera, T.K. Therapeutic and medicinal uses of lycopene: A systematic review. Int. J. Res. Med. Sci., 2020, 8(3), 1195.
[http://dx.doi.org/10.18203/2320-6012.ijrms20200804]
[13]
Cooperstone, J. L.; Ralston, R. A.; Riedl, K. M.; Haufe, T. C.; Schweiggert, R. M.; King, S. A.; Timmers, C. D.; Francis, D. M.; Lesinski, G. B.; Clinton, S. K.; Schwartz, S. J. Enhanced bioavailability of lycopene when consumed ascis-isomers fromtangerinecompared to red tomato juice, a randomized. Mol Nutr Food Res, 2015, 59(4), 658-69.
[14]
Woodside, J.V.; McGrath, A.J.; Lyner, N.; McKinley, M.C. Carotenoids and health in older people. Maturitas, 2015, 80(1), 63-68.
[http://dx.doi.org/10.1016/j.maturitas.2014.10.012] [PMID: 25466302]
[15]
Chauhan, K.; Sharma, S.; Agarwal, N.; Chauhan, B. Lycopene of tomato fame: Its role in health & disease. IJPSR, 2011, 10, 99-115.
[16]
Imran, M.; Ghorat, F.; Ul-Haq, I.; Ur-Rehman, H.; Aslam, F.; Heydari, M.; Shariati, M.A.; Okuskhanova, E.; Yessimbekov, Z.; Thiruvengadam, M.; Hashempur, M.H.; Rebezov, M. Lycopene as a natural antioxidant used to prevent human health disorders. Antioxidants, 2020, 9(8), 706.
[http://dx.doi.org/10.3390/antiox9080706] [PMID: 32759751]
[17]
Górecka, D.; Wawrzyniak, A.; Jędrusek-Golińska, A.; Dziedzic, K.; Hamułka, J.; Kowalczewski, P.Ł.; Walkowiak, J. Lycopene in tomatoes and tomato products. Open Chem., 2020, 18(1), 752-756.
[http://dx.doi.org/10.1515/chem-2020-0050]
[18]
Gajowik, A.; Dobrzyńska, M.M. Lycopene - antioxidant with radioprotective and anticancer properties. A review. Rocz. Panstw. Zakl. Hig., 2014, 65(4), 263-271.
[PMID: 25526570]
[19]
Asaduzzaman, M. Lycopene - A review: Chemistry, Source, Health Role, Extraction, applications. Annu. Res. Rev. Biol., 2022, 87-101.
[http://dx.doi.org/10.9734/arrb/2022/v37i230490]
[20]
Priyadarsani, S.; Patel, A.S.; Kar, A.; Dash, S. Process optimization for the supercritical carbondioxide extraction of lycopene from ripe grapefruit (Citrus paradisi) endocarp. Sci. Rep., 2021, 11(1), 10273.
[http://dx.doi.org/10.1038/s41598-021-89772-6] [PMID: 33986424]
[21]
Aniceto, J.P.S.; Rodrigues, V.H.; Portugal, I.; Silva, C.M. Valorization of Tomato Residues by Supercritical Fluid Extraction. Processes, 2021, 10(1), 28.
[http://dx.doi.org/10.3390/pr10010028]
[22]
Khaw, K.Y.; Parat, M.O.; Shaw, P.N.; Falconer, J.R. Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: A review. Molecules, 2017, 22(7), 1186.
[http://dx.doi.org/10.3390/molecules22071186] [PMID: 28708073]
[23]
de Andrade Lima, M.; Kestekoglou, I.; Charalampopoulos, D.; Chatzifragkou, A. Supercritical fluid extraction of carotenoids from vegetable waste matrices. Molecules, 2019, 24(3), 466.
[http://dx.doi.org/10.3390/molecules24030466] [PMID: 30696092]
[24]
Pathak, S.S.; Akhade, O.P.; Bhojane, K.G.; Sardar, M.D.; Folane, P.; Biyani, K.R. A review on recent techniques of extraction and isolation of lycopene from tomato. IJRR, 2020, 7(4), 487-490.
[25]
Malviya, N. Isolation and quantification of lycopene from watermelon, tomato and papaya. Res. J. Recent Sci., 2014, 30, 68-70.
[26]
Sohail, M.; Naveed, A.; Abdul, R.; Gulfishan; Muhammad Shoaib Khan, H.; Khan, H. An approach to enhanced stability: Formulation and characterization of Solanum lycopersicum derived lycopene based topical emulgel. Saudi Pharm. J., 2018, 26(8), 1170-1177.
[http://dx.doi.org/10.1016/j.jsps.2018.07.005] [PMID: 30532638]
[27]
Nazemiyeh, E.; Eskandani, M.; Sheikhloie, H.; Nazemiyeh, H. Formulation and physicochemical characterization of lycopene-loaded solid lipid nanoparticles. Adv Pharm Bull, 2016, 6(2), 235-41.
[http://dx.doi.org/10.15171/apb.2016.032]
[28]
Bockuviene, A.; Zalneravicius, R.; Sereikaite, J. Preparation, characterization and stability investigation of lycopene-chitooligosaccharides complexes. Food Biosci., 2021, 40, 100854.
[http://dx.doi.org/10.1016/j.fbio.2020.100854]
[29]
Catalkaya, G.; Kahveci, D. Optimization of enzyme assisted extraction of lycopene from industrial tomato waste. Separ. Purif. Tech., 2019, 219, 55-63.
[http://dx.doi.org/10.1016/j.seppur.2019.03.006]
[30]
Mai, H.C.; Tran, P.M. Enzyme-assisted extraction of lycopene from watermelon fruits: Effect of hydrolysis parameters on lycopene yield. Int J Adv Eng Res Sci, 2020, 7(5), 401-405.
[http://dx.doi.org/10.22161/ijaers.75.48]
[31]
Hussain, M.B.; Ahmad, R.S.; Waheed, M.; Rehman, T.U.; Majeed, M.; Khan, M.U.; Shariati, M.A.; Plygun, S.A.; Glinushkin, A.P. Extraction and characterization of lycopene from tomato and tomato products. Russ. J. Agric. Soc.-Econ. Sci., 2017, 63(3), 195-202.
[http://dx.doi.org/10.18551/rjoas.2017-03.24]
[32]
Oe-sook, M.; Moon, J. Method for obtaining purified lycopene and water-soluble lycopene from tomato. KR Patent 101112053B1, 2012.
[33]
Kumar, T.K.S.; Sherena, P.A. Efficient process for the preparation of lycopene containing oleoresin and lycopene crystals for human consumption. EP Patent 1886719A1, 2016.
[34]
Rey, E.S. Method of preparing lycopene-enriched formulations that are free of organic solvents, formulations thus obtained, compositions comprising sad formulations and use of same. EP Patent 1886719A1, 2009.
[35]
Petyaev, I; Bash, G Lycopene for the treatment for metabolic dysfunction. US Patent 20120316249A1, 2012.
[36]
Lei, C.; Qingyu, W.; Yun, J.; Mengyao, W.; Huimin, H. Nano-carrier loaded with lycopene, preparation method and application. CN Patent 110613135A, 2019.
[37]
Peijin, Y.; Wei, F.; Jianmin, X. Lycopene compound preparation with auxillary treatment effect on perostrate cancer and application thereof. CN Patent 108451979B, 2018.
[38]
Gao, W.; Xu, J.; Yang, X.; Tian, H.; Li, Y.; Jia, X. Lycopene micro - capsule powder and preparation method thereof. US Patent 20200297655A1, 2020.
[39]
Mousa, S.A.; Qari, M.H.; Ardawi, M.S.M. Composition of nanoformulated lycopene and method of using the composition. US Patent 9956181B2, 2018.
[40]
Jinfang, Z.; An, Y.; Xiaowei, B. Lycopene-loaded self-assembled nanomicelles and preparation method thereof. CN Patent 108309936B, 2018.
[41]
Campos, K.K.D.; Araújo, G.R.; Martins, T.L.; Bandeira, A.C.B.; Costa, G.P.; Talvani, A.; Garcia, C.C.M.; Oliveira, L.A.M.; Costa, D.C.; Bezerra, F.S. The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke. J. Nutr. Biochem., 2017, 48, 9-20.
[http://dx.doi.org/10.1016/j.jnutbio.2017.06.004] [PMID: 28651168]
[42]
Young, A.J.; Lowe, G.M. Antioxidant and prooxidant properties of carotenoids. Arch. Biochem. Biophys., 2001, 385(1), 20-27.
[http://dx.doi.org/10.1006/abbi.2000.2149] [PMID: 11361018]
[43]
Maoka, T. Carotenoids as natural functional pigments. J. Nat. Med., 2020, 74(1), 1-16.
[http://dx.doi.org/10.1007/s11418-019-01364-x] [PMID: 31588965]
[44]
Leh, H.E.; Lee, L.K. Lycopene: A potent antioxidant for the amelioration of type II diabetes mellitus. Molecules, 2022, 27(7), 2335.
[http://dx.doi.org/10.3390/molecules27072335] [PMID: 35408734]
[45]
El-Ashmawy, N.E.; Khedr, N.F.; El-Bahrawy, H.A.; Hamada, O.B. Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis. Dig. Liver Dis., 2018, 50(6), 601-607.
[http://dx.doi.org/10.1016/j.dld.2018.01.131] [PMID: 29439880]
[46]
Bedir, F.; Kocaturk, H.; Turangezli, O.; Sener, E.; Akyuz, S.; Ozgeris, F.B.; Dabanlioglu, B.; Suleyman, H.; Altuner, D.; Suleyman, B. The protective effect of lycopene against oxidative kidney damage associated with combined use of isoniazid and rifampicin in rats. Braz. J. Med. Biol. Res., 2021, 54(8), e10660.
[http://dx.doi.org/10.1590/1414-431x2020e10660] [PMID: 34037090]
[47]
Lin, R.; Zhang, C.; Zheng, J.; Tian, D.; Lei, Z.; Chen, D.; Xu, Z.; Su, M. Chronic inflammation-associated genomic instability paves the way for human esophageal carcinogenesis. Oncotarget, 2016, 7(17), 24564-24571.
[http://dx.doi.org/10.18632/oncotarget.8356] [PMID: 27028857]
[48]
Kelkel, M.; Schumacher, M.; Dicato, M.; Diederich, M. Antioxidant and anti-proliferative properties of lycopene. Free Radic. Res., 2011, 45(8), 925-940.
[http://dx.doi.org/10.3109/10715762.2011.564168] [PMID: 21615277]
[49]
dos Santos, R.C.; Ombredane, A.S.; Souza, J.M.T.; Vasconcelos, A.G.; Plácido, A.; Amorim, A.G.N.; Barbosa, E.A.; Lima, F.C.D.A.; Ropke, C.D.; Alves, M.M.M.; Arcanjo, D.D.R.; Carvalho, F.A.A.; Delerue-Matos, C.; Joanitti, G.A.; Leite, J.R.S.A. Lycopene-rich extract from red guava ( Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway. Food Res. Int., 2018, 105, 184-196.
[http://dx.doi.org/10.1016/j.foodres.2017.10.045] [PMID: 29433206]
[50]
Sahin, K.; Yenice, E.; Tuzcu, M.; Orhan, C.; Mizrak, C.; Ozercan, I.H.; Sahin, N.; Yilmaz, B.; Bilir, B.; Ozpolat, B.; Kucuk, O. Lycopene protects against spontaneous ovarian cancer formation in laying hens. J. Cancer Prev., 2018, 23(1), 25-36.
[http://dx.doi.org/10.15430/JCP.2018.23.1.25] [PMID: 29629346]
[51]
Paur, I.; Lilleby, W.; Bøhn, S.K.; Hulander, E.; Klein, W.; Vlatkovic, L.; Axcrona, K.; Bolstad, N.; Bjøro, T.; Laake, P.; Taskén, K.A.; Svindland, A.; Eri, L.M.; Brennhovd, B.; Carlsen, M.H.; Fosså, S.D.; Smeland, S.S.; Karlsen, A.S.; Blomhoff, R. Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA. Clin. Nutr., 2017, 36(3), 672-679.
[http://dx.doi.org/10.1016/j.clnu.2016.06.014] [PMID: 27406859]
[52]
Qi, W.J.; Sheng, W.S.; Peng, C.; Xiaodong, M.; Yao, T.Z. Investigating into anti-cancer potential of lycopene: Molecular targets. Biomed. Pharmacother., 2021, 138(111546), 111546.
[http://dx.doi.org/10.1016/j.biopha.2021.111546] [PMID: 34311540]
[53]
Tao, A.; Wang, X.; Li, C. Effect of lycopene on oral squamous cell carcinoma cell growth by inhibiting IGF1 pathway. Cancer Manag. Res., 2021, 13, 723-732.
[http://dx.doi.org/10.2147/CMAR.S283927] [PMID: 33531840]
[54]
Costa-Rodrigues, J.; Pinho, O.; Monteiro, P.R.R. Can lycopene be considered an effective protection against cardiovascular disease? Food Chem., 2018, 245, 1148-1153.
[http://dx.doi.org/10.1016/j.foodchem.2017.11.055] [PMID: 29287334]
[55]
He, Y.; Xia, P.; Jin, H.; Zhang, Y.; Chen, B.; Xu, Z. Lycopene ameliorates transplant arteriosclerosis in vascular allograft transplantation by regulating the NO/cGMP pathways and rho-associated kinases expression. Oxid. Med. Cell. Longev., 2016, 2016, 1-9.
[http://dx.doi.org/10.1155/2016/3128280] [PMID: 28050227]
[56]
Jacques, P.F.; Lyass, A.; Massaro, J.M.; Vasan, R.S.; D’Agostino, R.B., Sr Relationship of lycopene intake and consumption of tomato products to incident CVD. Br. J. Nutr., 2013, 110(3), 545-551.
[http://dx.doi.org/10.1017/S0007114512005417] [PMID: 23317928]
[57]
Cheng, H.M.; Koutsidis, G.; Lodge, J.K.; Ashor, A.; Siervo, M.; Lara, J. Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis. Atherosclerosis, 2017, 257, 100-108.
[http://dx.doi.org/10.1016/j.atherosclerosis.2017.01.009] [PMID: 28129549]
[58]
Song, B.; Liu, K.; Gao, Y.; Zhao, L.; Fang, H.; Li, Y.; Pei, L.; Xu, Y. Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies. Mol. Nutr. Food Res., 2017, 61(9), 1601009.
[http://dx.doi.org/10.1002/mnfr.201601009] [PMID: 28318092]
[59]
Thies, F.; Mills, L.M.; Moir, S.; Masson, L.F. Cardiovascular benefits of lycopene: Fantasy or reality? Proc. Nutr. Soc., 2017, 76(2), 122-129.
[http://dx.doi.org/10.1017/S0029665116000744] [PMID: 27609297]
[60]
He, Q.; Zhou, W.; Xiong, C.; Tan, G.; Chen, M. Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway. Mol. Med. Rep., 2015, 11(1), 374-378.
[http://dx.doi.org/10.3892/mmr.2014.2676] [PMID: 25323011]
[61]
Wang, J.; Tang, X.; Lu, Y.; Zheng, Y.; Zeng, F.; Shi, W.; Zhou, P. Lycopene regulates dietary dityrosine‐induced mitochondrial‐lipid homeostasis by increasing mitochondrial complex activity. Mol. Nutr. Food Res., 2022, 66(1), 2100724.
[http://dx.doi.org/10.1002/mnfr.202100724] [PMID: 34780105]
[62]
Karimian, B.; Soleimani, A.; Mohammadsharifi, G.; Heshmat-Ghahdarijani, K.; Rejali, L.; Shafie, D.; Amerizadeh, A.; Sadeghi, M. Effect of lycopene supplementation on some cardiovascular risk factors and markers of endothelial function in iranian patients with ischemic heart failure: A randomized clinical trial. Cardiol. Res. Pract., 2022, 2022, 1-7.
[http://dx.doi.org/10.1155/2022/2610145] [PMID: 36337273]
[63]
Chen, L.; Deng, H.; Cui, H.; Fang, J.; Zuo, Z.; Deng, J.; Li, Y.; Wang, X.; Zhao, L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 2018, 9(6), 7204-7218.
[http://dx.doi.org/10.18632/oncotarget.23208] [PMID: 29467962]
[64]
Greten, F.R.; Grivennikov, S.I. Inflammation and cancer: Triggers, mechanisms, and consequences. Immunity, 2019, 51(1), 27-41.
[http://dx.doi.org/10.1016/j.immuni.2019.06.025] [PMID: 31315034]
[65]
Honarvar, N.M.; Saedisomeolia, A.; Abdolahi, M.; Shayeganrad, A.; Taheri Sangsari, G.; Rad, B.H.; Muench, G. Molecular anti-inflammatory mechanisms of retinoids and carotenoids in alzheimer’s disease: A review of current evidence. J Mol Neurosci : MN, 2017, 61(3), 289-304.
[http://dx.doi.org/10.1007/s12031-016-0857-x]
[66]
Fernandes, J.V.; Cobucci, R.N.O.; Jatobá, C.A.N.; de Medeiros Fernandes, T.A.A.; de Azevedo, J.W.V.; de Araújo, J.M.G. The role of the mediators of inflammation in cancer development. Pathol. Oncol. Res., 2015, 21(3), 527-534.
[http://dx.doi.org/10.1007/s12253-015-9913-z] [PMID: 25740073]
[67]
Simone, R.E.; Russo, M.; Catalano, A.; Monego, G.; Froehlich, K.; Boehm, V.; Palozza, P. Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARγ signalling in cigarette smoke-stimulated macrophages. PLoS One, 2011, 6(5), e19652.
[http://dx.doi.org/10.1371/journal.pone.0019652] [PMID: 21625550]
[68]
Vasconcelos, A.G.; Amorim, A.G.N.; dos Santos, R.C.; Souza, J.M.T.; de Souza, L.K.M.; Araújo, T.S.L.; Nicolau, L.A.D.; de Lima Carvalho, L.; de Aquino, P.E.A.; da Silva Martins, C.; Ropke, C.D.; Soares, P.M.G.; Kuckelhaus, S.A.S.; Medeiros, J.V.R.; Leite, J.R.S.A. Lycopene rich extract from red guava (Psidium guajava L.) displays anti-inflammatory and antioxidant profile by reducing suggestive hallmarks of acute inflammatory response in mice. Food Res. Int., 2017, 99(Pt 2), 959-968.
[http://dx.doi.org/10.1016/j.foodres.2017.01.017] [PMID: 28847433]
[69]
Alhoshani, N.M.; Al-Zharani, M.; Almutairi, B.; Aljarba, N.H.; AL-Johani, N.S.; Alkeraishan, N.; AlKahtane, A.A.; Alarifi, S.; Ali, D.; Alkahtani, S. Antioxidant and anti-inflammatory activities of lycopene against 5-fluorouracil-induced cytotoxicity in Caco2 cells. Saudi Pharm. J., 2022, 30(11), 1665-1671.
[http://dx.doi.org/10.1016/j.jsps.2022.09.011] [PMID: 36465840]
[70]
Malhotra, H.; Kamboj, A.; Kaushik, P.; Gautam, R.K. Interplay of microbiome, inflammation, and immunity in inflammatory lung diseases. In: In: Microbiome in Inflammatory Lung Diseases; Springer: Singapore, 2022; pp. 43-64.
[http://dx.doi.org/10.1007/978-981-16-8957-4_4]
[71]
Li, X.; Xu, J. Lycopene supplement and blood pressure: An updated meta-analysis of intervention trials. Nutrients, 2013, 5(9), 3696-3712.
[http://dx.doi.org/10.3390/nu5093696] [PMID: 24051501]
[72]
Przybylska, S. Lycopene - a bioactive carotenoid offering multiple health benefits: A review. Int. J. Food Sci. Technol., 2020, 55(1), 11-32.
[http://dx.doi.org/10.1111/ijfs.14260]
[73]
Saini, R.K.; Rengasamy, K.R.R.; Mahomoodally, F.M.; Keum, Y.S. Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives. Pharmacol. Res., 2020, 155, 104730.
[http://dx.doi.org/10.1016/j.phrs.2020.104730] [PMID: 32126272]
[74]
Han, G.M.; Liu, P. Higher serum lycopene is associated with reduced prevalence of hypertension in overweight or obese adults. Eur. J. Integr. Med., 2017, 13, 34-40.
[http://dx.doi.org/10.1016/j.eujim.2017.07.002]
[75]
Okafor, A.C.; Luke, M.N.; Adaobi, O.P.; Obinna, O.K.; Nonso, N.R.; Onyinye, O.P.; John, C.B.; Uchenna, A.F.; Somke, A.P.; Edorisiagbon, E.I.; Omire-Oluedo, O.; Chukwu, N.D. Investigation of the effect and possible mechanism of antihypertensive activity of lycopene-rich extract of solanum lycopersicon in wistar rats. Int. J. Clin. Exp. Physiol., 2022, 9(2), 80-87.
[http://dx.doi.org/10.5530/ijcep.2022.9.2.17]
[76]
Ferreira-Santos, P.; Carrón, R.; Montero, M.J.; Sevilla, M.Á. The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age. J. Funct. Foods, 2021, 85, 104656.
[http://dx.doi.org/10.1016/j.jff.2021.104656]
[77]
Yin, Y.; Zheng, Z.; Jiang, Z. Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats. Biomed. Pharmacother., 2019, 109, 2070-2077.
[http://dx.doi.org/10.1016/j.biopha.2018.07.100] [PMID: 30551463]
[78]
Soleymaninejad, M.; Joursaraei, S.G.; Feizi, F.; Jafari Anarkooli, I. The effects of lycopene and insulin on histological changes and the expression level of Bcl-2 family genes in the hippocampus of streptozotocin-induced diabetic rats. J. Diabetes Res., 2017, 2017, 1-9.
[http://dx.doi.org/10.1155/2017/4650939] [PMID: 28656152]
[79]
Ozmen, O.; Topsakal, S.; Haligur, M.; Aydogan, A.; Dincoglu, D. Effects of caffeine and lycopene in experimentally induced diabetes mellitus. Pancreas, 2016, 45(4), 579-583.
[http://dx.doi.org/10.1097/MPA.0000000000000489] [PMID: 26418913]
[80]
Leh, H.E.; Mohd Sopian, M.; Abu Bakar, M.H.; Lee, L.K. The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: A case-control study. Ann. Med., 2021, 53(1), 1060-1066.
[http://dx.doi.org/10.1080/07853890.2021.1943515] [PMID: 34180336]
[81]
Guo, Y.; Liu, Y.; Wang, Y. Beneficial effect of lycopene on anti-diabetic nephropathy through diminishing inflammatory response and oxidative stress. Food Funct., 2015, 6(4), 1150-1156.
[http://dx.doi.org/10.1039/C5FO00004A] [PMID: 25689917]
[82]
Singh, Y.; Sodhi, R.K.; Chahal, S.K.; Madan, J. Diabetic neuropathy: Pathogenesis and therapeutic management. In: Diabetes and Diabetic Complications: Current Status and Future Perspectives; Dahiya, R.S.; Singh, T.G., Eds.; Nova Science Publishers, Inc.: New York, 2021; pp. 100-122.
[83]
Paul, R.; Mazumder, M.K.; Nath, J.; Deb, S.; Paul, S.; Bhattacharya, P.; Borah, A. Lycopene - A pleiotropic neuroprotective nutraceutical: Deciphering its therapeutic potentials in broad spectrum neurological disorders. Neurochem Int, 2020, 140, 104823.https://pubmed.ncbi.nlm.nih.gov/32827559/
[84]
Prema, A.; Janakiraman, U.; Manivasagam, T.; Justin Thenmozhi, A. Neuroprotective effect of lycopene against MPTP induced experimental Parkinson’s disease in mice. Neurosci. Lett., 2015, 599, 12-19.
[http://dx.doi.org/10.1016/j.neulet.2015.05.024] [PMID: 25980996]
[85]
Zhao, B.; Ren, B.; Guo, R.; Zhang, W.; Ma, S.; Yao, Y.; Yuan, T.; Liu, Z.; Liu, X. Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway. Food Chem. Toxicol., 2017, 109(Pt 1), 505-516.
[http://dx.doi.org/10.1016/j.fct.2017.09.050] [PMID: 28974442]
[86]
Datta, S.; Jamwal, S.; Deshmukh, R.; Kumar, P. Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Possible neurotransmitters and neuroinflammation modulation. Eur J Pharmacol, 2016, 771, 229-35.
[87]
Lu, C.W.; Hung, C.F.; Jean, W.H.; Lin, T.Y.; Huang, S.K.; Wang, S.J. Lycopene depresses glutamate release through inhibition of voltage-dependent Ca 2+ entry and protein kinase C in rat cerebrocortical nerve terminals. Can. J. Physiol. Pharmacol., 2018, 96(5), 479-484.
[http://dx.doi.org/10.1139/cjpp-2017-0520] [PMID: 29216442]
[88]
Bhardwaj, M.; Kumar, A. Effect of lycopene against PTZ-Induced kindling seizures in mice: Possible behavioural, biochemical and mitochondrial dysfunction. Phytother. Res., 2015, 30(2), 306-313.
[89]
Liu, C.B.; Wang, R.; Pan, H.B.; Ding, Q.F.; Lu, F.B. Effect of lycopene on oxidative stress and behavioral deficits in rotenone induced model of parkinson’s disease. Chin. J. Appl. Physiol., 2013, 29, 380-384.
[90]
Ning, W.; Lv, R.; Xu, N.; Hou, X.; Shen, C.; Guo, Y.; Fan, Z.; Cao, N.; Liu, X.P. Lycopene-loaded microemulsion regulates neurogenesis in rats with aβ-induced alzheimer’s disease rats based on the Wnt/β-catenin pathway. Neural Plast., 2021, 2021, 1-15.
[http://dx.doi.org/10.1155/2021/5519330] [PMID: 34545285]
[91]
Shimizu, Y.; Mashima-Nemoto, T.; Hazawa, M.; Taira, Y.; Taira, I.; Ishida, I.; Isoda, K. The hepatoprotective effect of lycopene on Con A-induced liver injury in mice. Pharmazie, 2018, 73(7), 393-395.
[http://dx.doi.org/10.1691/ph.2018.8437] [PMID: 30001773]
[92]
Abdel-Rahman, H.G.; Abdelrazek, H.M.A.; Zeidan, D.W.; Mohamed, R.M.; Abdelazim, A.M. Lycopene: Hepatoprotective and antioxidant effects toward bisphenol a-induced toxicity in female wistar rats. Oxid. Med. Cell. Longev., 2018, 2018, 1-8.
[http://dx.doi.org/10.1155/2018/5167524] [PMID: 30147835]
[93]
Jiang, W.; Guo, M.H.; Hai, X. Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. World J. Gastroenterol., 2016, 22(46), 10180-10188.
[http://dx.doi.org/10.3748/wjg.v22.i46.10180] [PMID: 28028366]
[94]
Sheik Abdulazeez, S.; Thiruvengadam, D. Effect of lycopene on oxidative stress induced during D -galactosamine/lipopolysaccharide-sensitized liver injury in rats. Pharm. Biol., 2013, 51(12), 1592-1599.
[http://dx.doi.org/10.3109/13880209.2013.803579] [PMID: 24028090]
[95]
Deng, Y.; Xu, Z.; Liu, W.; Yang, H.; Xu, B.; Wei, Y. Effects of lycopene and proanthocyanidins on hepatotoxicity induced by mercuric chloride in rats. Biol. Trace Elem. Res., 2012, 146(2), 213-223.
[http://dx.doi.org/10.1007/s12011-011-9242-3] [PMID: 22048885]
[96]
Karaca, A.; Yilmaz, S.; Kaya, E.; Altun, S. The effect of lycopene on hepatotoxicity of aflatoxin B1 in rats. Arch. Physiol. Biochem., 2021, 127(5), 429-436.
[http://dx.doi.org/10.1080/13813455.2019.1648516] [PMID: 31378089]
[97]
Zhao, Y.; Bao, R.K.; Zhu, S.Y.; Talukder, M.; Cui, J.G.; Zhang, H.; Li, X.N.; Li, J.L. Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR–Nrf2 pathway. Environ. Pollut., 2021, 285, 117080.
[http://dx.doi.org/10.1016/j.envpol.2021.117080] [PMID: 33965855]
[98]
Dilokthornsakul, W.; Dhippayom, T.; Dilokthornsakul, P. The protective effect of lycopene-rich products on skin photodamage: A systematic review and meta-analysis of randomized controlled trials. Thaiphesatchasan, 2018, 42, 176-182.
[99]
Petyaev, I.M.; Pristensky, D.V.; Morgunova, E.Y.; Zigangirova, N.A.; Tsibezov, V.V.; Chalyk, N.E.; Klochkov, V.A.; Blinova, V.V.; Bogdanova, T.M.; Iljin, A.A.; Sulkovskaya, L.S.; Chernyshova, M.P.; Lozbiakova, M.V.; Kyle, N.H.; Bashmakov, Y.K. Lycopene presence in facial skin corneocytes and sebum and its association with circulating lycopene isomer profile: Effects of age and dietary supplementation. Food Sci. Nutr., 2019, 7(4), 1157-1165.
[http://dx.doi.org/10.1002/fsn3.799] [PMID: 31024688]
[100]
Rizwan, M.; Rodriguez-Blanco, I.; Harbottle, A.; Birch-Machin, M.A.; Watson, R.E.B.; Rhodes, L.E. Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: A randomized controlled trial. Br. J. Dermatol., 2011, 164(1), 154-162.
[http://dx.doi.org/10.1111/j.1365-2133.2010.10057.x] [PMID: 20854436]
[101]
Sokoloski, L.; Borges, M.; Bagatin, E. Lycopene not in pill, nor in natura has photoprotective systemic effect. Arch. Dermatol. Res., 2015, 307(6), 545-549.
[http://dx.doi.org/10.1007/s00403-015-1578-7] [PMID: 26024575]
[102]
Grether-Beck, S.; Marini, A.; Jaenicke, T.; Stahl, W.; Krutmann, J. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, crossover study. Br. J. Dermatol., 2017, 176(5), 1231-1240.
[http://dx.doi.org/10.1111/bjd.15080] [PMID: 27662341]
[103]
Shih, C.M.; Hsieh, C.K.; Huang, C.Y.; Huang, C.Y.; Wang, K.H.; Fong, T.H.; Trang, N.T.T.; Liu, K.T.; Lee, A.W. Lycopene inhibit IMQ-induced psoriasis-like inflammation by inhibiting ICAM-1 production in mice. Polymers, 2020, 12(7), 1521.
[http://dx.doi.org/10.3390/polym12071521] [PMID: 32659890]
[104]
Chen, P.; Xu, S.; Qu, J. Lycopene protects keratinocytes against UVB radiation‐induced carcinogenesis via negative regulation of FOXO3a through the mTORC2/AKT signaling pathway. J. Cell. Biochem., 2018, 119(1), 366-377.
[http://dx.doi.org/10.1002/jcb.26189] [PMID: 28585698]
[105]
Sohail, M.; Muhammad Faran Ashraf Baig, M.; Akhtar, N.; Chen, Y.; Xie, B.; Li, B. Topical lycopene emulgel significantly improves biophysical parameters of human skin. Eur. J. Pharm. Biopharm., 2022, 180, 281-288.
[http://dx.doi.org/10.1016/j.ejpb.2022.10.016] [PMID: 36283632]
[106]
Yamamoto, Y.; Aizawa, K.; Mieno, M.; Karamatsu, M.; Hirano, Y.; Furui, K.; Miyashita, T.; Yamazaki, K.; Inakuma, T.; Sato, I.; Suganuma, H.; Iwamoto, T. The effects of tomato juice on male infertility. Asia Pac. J. Clin. Nutr., 2017, 26(1), 65-71.
[http://dx.doi.org/10.6133/apjcn.102015.17] [PMID: 28049263]
[107]
Agarwal, A.; Sekhon, L.H. The role of antioxidant therapy in the treatment of male infertility. Hum. Fertil., 2010, 13(4), 217-225.
[http://dx.doi.org/10.3109/14647273.2010.532279] [PMID: 21117931]
[108]
Ghyasvand, T.; Goodarzi, M.T.; Amiri, I.; Karimi, J.; Ghorbani, M. Serum levels of lycopene, beta-carotene, and retinol and their correlation with sperm DNA damage in normospermic and infertile men. Int. J. Reprod. Biomed., 2015, 13(12), 787-792.
[http://dx.doi.org/10.29252/ijrm.13.12.787] [PMID: 27141539]
[109]
Babaei, A.; Asadpour, R.; Mansouri, K.; Sabrivand, A.; Kazemi-Darabadi, S. Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia. Food Sci. Nutr., 2022, 10(5), 1469-1480.
[http://dx.doi.org/10.1002/fsn3.2762] [PMID: 35592276]
[110]
Agarwal, A.; Durairajanayagam, D.; Ong, C.; Prashast, P. Lycopene and male infertility. Asian J. Androl., 2014, 16(3), 420-425.
[http://dx.doi.org/10.4103/1008-682X.126384] [PMID: 24675655]
[111]
Aly, H.A.A.; El-Beshbishy, H.A.; Banjar, Z.M. Mitochondrial dysfunction induced impairment of spermatogenesis in LPS-treated rats: Modulatory role of lycopene. Eur. J. Pharmacol., 2012, 677(1-3), 31-38.
[http://dx.doi.org/10.1016/j.ejphar.2011.12.027] [PMID: 22222822]
[112]
Mangiagalli, M.G.; Martino, P.A.; Smajlovic, T.; Guidobono Cavalchini, L.; Marelli, S.P. Effect of lycopene on semen quality, fertility and native immunity of broiler breeder. Br. Poult. Sci., 2010, 51(1), 152-157.
[http://dx.doi.org/10.1080/00071660903401540] [PMID: 20390581]
[113]
Williams, E.A.; Parker, M.; Robinson, A.; Pitt, S.; Pacey, A.A. A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males. Eur. J. Nutr., 2020, 59(2), 825-833.
[http://dx.doi.org/10.1007/s00394-019-02091-5] [PMID: 31591650]
[114]
Walallawita, U.S.; Wolber, F.M.; Ziv-Gal, A.; Kruger, M.C.; Heyes, J.A. Potential role of lycopene in the prevention of postmenopausal bone loss: Evidence from molecular to clinical studies. Int. J. Mol. Sci., 2020, 21(19), 7119.
[http://dx.doi.org/10.3390/ijms21197119] [PMID: 32992481]
[115]
Costa-Rodrigues, J.; Fernandes, M.H.; Pinho, O.; Monteiro, P.R.R. Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene. J. Nutr. Biochem., 2018, 57, 26-34.
[http://dx.doi.org/10.1016/j.jnutbio.2018.03.004] [PMID: 29655028]
[116]
Oliveira, G.R.; Vargas-Sanchez, P.K.; Fernandes, R.R.; Ricoldi, M.S.T.; Semeghini, M.S.; Pitol, D.L.; de Sousa, L.G.; Siessere, S.; Bombonato-Prado, K.F. Lycopene influences osteoblast functional activity and prevents femur bone loss in female rats submitted to an experimental model of osteoporosis. J. Bone Miner. Metab., 2019, 37(4), 658-667.
[http://dx.doi.org/10.1007/s00774-018-0970-8] [PMID: 30357566]
[117]
Mackinnon, E.S.; Rao, A.V.; Rao, L.G. Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women. J. Nutr. Health Aging, 2010, 15(2), 133-8.
[http://dx.doi.org/10.1007/s12603-011-0026-4] [PMID: 21365167]
[118]
Ardawi, M.S.M.; Badawoud, M.H.; Hassan, S.M.; Rouzi, A.A.; Ardawi, J.M.S.; AlNosani, N.M.; Qari, M.H.; Mousa, S.A. Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model. Bone, 2016, 83, 127-140.
[http://dx.doi.org/10.1016/j.bone.2015.10.017] [PMID: 26549245]
[119]
Iimura, Y.; Agata, U.; Takeda, S.; Kobayashi, Y.; Yoshida, S.; Ezawa, I.; Omi, N. The protective effect of lycopene intake on bone loss in ovariectomized rats. J. Bone Miner. Metab., 2015, 33(3), 270-278.
[http://dx.doi.org/10.1007/s00774-014-0596-4] [PMID: 24996525]
[120]
Semeghini, M.S.; Scalize, P.H.; Coelho, M.C.; Fernandes, R.R.; Pitol, D.L.; Tavares, M.S.; de Sousa, L.G.; Coppi, A.A.; Siessere, S.; Bombonato-Prado, K.F. Lycopene prevents bone loss in ovariectomized rats and increases the number of osteocytes and osteoblasts. J. Anat., 2022, 241(3), 729-740.
[http://dx.doi.org/10.1111/joa.13672] [PMID: 35445391]
[121]
Russo, C.; Ferro, Y.; Maurotti, S.; Salvati, M.A.; Mazza, E.; Pujia, R.; Terracciano, R.; Maggisano, G.; Mare, R.; Giannini, S.; Romeo, S.; Pujia, A.; Montalcini, T. Lycopene and bone: An in vitro investigation and a pilot prospective clinical study. J. Transl. Med., 2020, 18(1), 43.
[http://dx.doi.org/10.1186/s12967-020-02238-7] [PMID: 31996227]
[122]
Gonelimali, F.D.; Lin, J.; Miao, W.; Xuan, J.; Charles, F.; Chen, M.; Hatab, S.R. Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Front. Microbiol., 2018, 9, 1639.
[http://dx.doi.org/10.3389/fmicb.2018.01639] [PMID: 30087662]
[123]
Nedamani, R.E. Brief report antimicrobial property of lycopene oleoresin on some food pathogens running head. Lycopene oleoresin antibacterial potent. Iranian Food Sci. Technol. Res. J., 2016, 12(3), 382-387.
[124]
Tang, T.; Peng; Ni; Zheng; Shen; Wang; He; Jin Dual effects and mechanism of TiO2 nanotube arrays in reducing bacterial colonization and enhancing C3H10T1/2 cell adhesion. Int. J. Nanomedicine, 2013, 3093, 3093.
[http://dx.doi.org/10.2147/IJN.S48084]
[125]
Murthykumar, K.; Malaiappan, S. Antioxidant and antibacterial effect of lycopene mediated silver nanoparticle against staphylococcus aureus and streptococcus mutans an in vitro study. Plant Cell Biotechnol. Mol. Biol., 2020, 21, 90-98.
[126]
Zigangirova, N.A.; Morgunova, E.Y.; Fedina, E.D.; Shevyagina, N.V.; Borovaya, T.G.; Zhukhovitsky, V.G.; Kyle, N.H.; Petyaev, I.M. Lycopene inhibits propagation of chlamydia infection. Scientifica, 2017, 2017, 1-11.
[http://dx.doi.org/10.1155/2017/1478625] [PMID: 28948060]
[127]
Alshahrani, M.Y.; Ibrahim, E.H.; Asiri, M.; Kilany, M.; Alkhathami, A.G.; Alshahrani, M.N.; Chandramoorthy, H.C. Lycopene augments and enhances anti-oxidant/antibacterial efficiency of ethanolic leaf extract of Helianthus annuus over multidrug-resistant bacterial isolates. J. King Saud Univ. Sci., 2022, 34(7), 102250.
[http://dx.doi.org/10.1016/j.jksus.2022.102250]
[128]
Karemore, T.; Motwani, M. Evaluation of the effect of newer antioxidant lycopene in the treatment of oral submucous fibrosis. Indian J. Dent. Res., 2012, 23(4), 524-528.
[http://dx.doi.org/10.4103/0970-9290.104964] [PMID: 23257490]
[129]
Nayak, A.; Anitha, B.; Bhattacharya, A.; Podder, S. Efficacy of lycopene in combination with vitamin e in management of oral submucus fibrosis-a clinical prospective study. J. Adv. Med. Dental Sci. Res., 2015, 3(3), 21-25.
[130]
Niranzena, P.S.; Dayanand, A.A. Lycopene in the management of oral submucous fibrosis. Asian J. Pharm. Clin. Res., 2013, 6, 58-61.
[131]
Katalin, P.R.; Annamária, K.; Bardos, L.; Zsuzsanna, K. The place of absorption of lycopene and the characteristics of its deposition into the yolk in japanese quail (Model Experiment). Magy. Állatorv. Lapja, 2011, 133, 526-532.
[132]
Kapała, A.; Szlendak, M.; Motacka, E. The anti-cancer activity of lycopene: A systematic review of human and animal studies. Nutrients, 2022, 14(23), 5152.
[http://dx.doi.org/10.3390/nu14235152] [PMID: 36501182]
[133]
The effect of lycopene on sperm quality in men attending fertility clinic. NCT05671562, 2023.
[134]
Decipher lethal prostate cancer biology - urine metabolomics. NCT03237702, 2023.
[135]
Rezaei kelishadi, M.; Asbaghi, O.; Nazarian, B.; Naeini, F.; Kaviani, M.; Moradi, S.; Askari, G.; Nourian, M.; Ashtary-Larky, D. Lycopene Supplementation and Blood Pressure: Systematic review and meta-analyses of randomized trials. J. Herb. Med., 2022, 31(100521), 100521.
[http://dx.doi.org/10.1016/j.hermed.2021.100521]
[136]
Senkus, K.E.; Tan, L.; Crowe-White, K.M. Lycopene and metabolic syndrome: A systematic review of the literature. Adv. Nutr., 2019, 10(1), 19-29.
[http://dx.doi.org/10.1093/advances/nmy069] [PMID: 30475939]
[137]
Lü, W-L.; Rong, F.; Ping, Q-N. Preparation, dissolution and bioavailability of lycopene-poloxamer 188 solid dispersion. Zhongguo Yaoke Daxue Xuebao, 2009, 40, 514-518.
[138]
Stojiljkovic, N.; Ilic, S.; Jakovljevic, V.; Stojanovic, N.; Stojnev, S.; Kocic, H.; Stojanovic, M.; Kocic, G. The encapsulation of lycopene in nanoliposomes enhances its protective potential in methotrexate-induced kidney injury model. Oxid. Med. Cell. Longev., 2018, 2018, 1-11.
[http://dx.doi.org/10.1155/2018/2627917] [PMID: 29725494]
[139]
Ahmed, H.; Salama, Z.A.; Salem, S.H.; Aly, H.F.; Nassrallah, A.; Abou-Elella, F.; Aboul-Enein, A.M. Lycopene nanoparticles ameliorate the antioxidant, antimicrobial and anticancer potencies of tomato pomace. Egypt. J. Chem., 2021, 0(0), 0.https://ejchem.journals.ekb.eg/article_173591.html
[http://dx.doi.org/10.21608/ejchem.2021.71766.3583]
[140]
Pk, S. Novel encapsulation of lycopene in niosomes and assessment of its anticancer activity. J. Bioequivalence Bioavailab., 2016, 8(5)
[http://dx.doi.org/10.4172/jbb.1000300]
[141]
Shejawal, K.P.; Randive, D.S.; Bhinge, S.D.; Bhutkar, M.A.; Todkar, S.S.; Mulla, A.S.; Jadhav, N.R. Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: Their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell. J. Mater. Sci. Mater. Med., 2021, 32(2), 19.
[http://dx.doi.org/10.1007/s10856-021-06489-8] [PMID: 33576907]
[142]
Goswami, A.; Patel, N.; Bhatt, V.; Raval, M.; Kundariya, M.; Sheth, N. Lycopene loaded polymeric nanoparticles for prostate cancer treatment: Formulation, optimization using box-behnken design and cytotoxicity studies. J. Drug Deliv. Sci. Technol., 2021, 102930
[http://dx.doi.org/10.1016/j.jddst.2021.102930]
[143]
Singh, A.; Neupane, Y.R.; Panda, B.P.; Kohli, K. Lipid Based nanoformulation of lycopene improves oral delivery: Formulation optimization, ex vivo assessment and its efficacy against breast cancer. J. Microencapsul., 2017, 34(4), 416-429.
[http://dx.doi.org/10.1080/02652048.2017.1340355] [PMID: 28595495]
[144]
Vasconcelos, A.G.; Barros, A.L.; Cabral, W.F.; Moreira, D.C.; da Silva, I.G.M.; Silva-Carvalho, A.É.; de Almeida, M.P.; Albuquerque, L.F.F.; dos Santos, R.C.; Brito, S. Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): In vivo toxicity, biodistribution and cytotoxicity on du-145 prostate cancer cells. Cancer Nanotechnol., 2021, 12(1), 30.
[http://dx.doi.org/10.1186/s12645-021-00103-w]
[145]
Ascenso, A.; Pinho, S.; Eleutério, C.; Praça, F.G.; Bentley, M.V.L.B.; Oliveira, H.; Santos, C.; Silva, O.; Simões, S. Lycopene from tomatoes: Vesicular nanocarrier formulations for dermal delivery. J. Agric. Food Chem., 2013, 61(30), 7284-7293.
[http://dx.doi.org/10.1021/jf401368w] [PMID: 23826819]
[146]
Ghazi, A.M.; Al-Bayati, M.A. Anti- proliferative of the phytosome propolis, phytosome lycopene and synergistic effect on the benign prostatic hyperplasia cells in-vitro. Plant Arch., 2020, 20(2), 6579-6589.
[147]
Vasconcelos, A.G.; Valim, M.O.; Amorim, A.G.N.; do Amaral, C.P.; de Almeida, M.P.; Borges, T.K.S.; Socodato, R.; Portugal, C.C.; Brand, G.D.; Mattos, J.S.C.; Relvas, J.; Plácido, A.; Eaton, P.; Ramos, D.A.R.; Kückelhaus, S.A.S.; Leite, J.R.S.A. Cytotoxic activity of poly-ɛ-caprolactone lipid-core nanocapsules loaded with lycopene-rich extract from red guava (Psidium guajava L.) on breast cancer cells. Food Res. Int., 2020, 136, 109548.
[http://dx.doi.org/10.1016/j.foodres.2020.109548] [PMID: 32846600]
[148]
Shejawal, K.P.; Randive, D.S.; Bhinge, S.D.; Bhutkar, M.A.; Wadkar, G.H.; Todkar, S.S.; Mohite, S.K. Functionalized carbon nanotube for colon-targeted delivery of isolated lycopene in colorectal cancer: In vitro cytotoxicity and in vivo roentgenographic study. J. Mater. Res., 2021, 36(24), 4894-4907.
[http://dx.doi.org/10.1557/s43578-021-00431-y]
[149]
Balbuena, E.; Cheng, J.; Eroglu, A. The role of lycopene in chronic lung diseases. In: In: Antioxidants - Benefits, Sources, Mechanisms of Action; IntechOpen, 2021.
[http://dx.doi.org/10.5772/intechopen.95468]
[150]
Moia, V.M.; Leal Portilho, F.; Almeida Pádua, T.; Barbosa Corrêa, L.; Ricci-Junior, E.; Cruz Rosas, E.; Magalhaes Rebelo Alencar, L.; Savio Mendes Sinfronio, F.; Sampson, A.; Hussain Iram, S.; Alexis, F.; de OliveiraHenriques, M.; Santos-Oliveira, R. Lycopene used as anti-inflammatory nanodrug for the treatment of rheumathoid arthritis: Animal assay, pharmacokinetics, ABC transporter and tissue deposition. Colloids Surf. B Biointerfaces, 2020, 188(110814), 110814.
[http://dx.doi.org/10.1016/j.colsurfb.2020.110814] [PMID: 31982791]
[151]
Taheri, Z.; Ghafari, M.; Amiri, M. Lycopene and kidney; future potential application. J. Nephropharmacol., 2015, 4(2), 49-51.
[PMID: 28197476]
[152]
Radmehr, M. Comparison of the effect of lycopene with ibuprofen on sensory threshold of pain using formalin test in adult male rats. J. Chem. Pharm. Res., 2016, 8(4), 1322-1327.
[153]
Shao, A.; Hathcock, J.N. Risk assessment for the carotenoids lutein and lycopene. Regul. Toxicol. Pharmacol., 2006, 45(3), 289-298.
[http://dx.doi.org/10.1016/j.yrtph.2006.05.007] [PMID: 16814439]
[154]
Borel, P.; Desmarchelier, C.; Dumont, U.; Halimi, C.; Lairon, D.; Page, D.; Sébédio, J.L.; Buisson, C.; Buffière, C.; Rémond, D. Dietary calcium impairs tomato lycopene bioavailability in healthy humans. Br. J. Nutr., 2016, 116(12), 2091-2096.
[http://dx.doi.org/10.1017/S0007114516004335] [PMID: 28069089]
[155]
Sawardekar, S.; Patel, T.; Uchil, D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study. Indian J. Pharmacol., 2016, 48(1), 26-31.
[http://dx.doi.org/10.4103/0253-7613.174428] [PMID: 26997718]
[156]
Trumbo, P.R. Are there adverse effects of lycopene exposure? J. Nutr., 2005, 135(8), 2060S-2061S.
[http://dx.doi.org/10.1093/jn/135.8.2060S] [PMID: 16046742]
[157]
Bahadar, H.; Maqbool, F.; Niaz, K.; Abdollahi, M. Toxicity of nanoparticles and an overview of current experimental models. Iran. Biomed. J., 2016, 20(1), 1-11.
[http://dx.doi.org/10.7508/ibj.2016.01.001] [PMID: 26286636]
[158]
Bosetti, R.; Jones, S.L. Cost–effectiveness of nanomedicine: Estimating the real size of nano-costs. Nanomedicine, 2019, 14(11), 1367-1370.
[http://dx.doi.org/10.2217/nnm-2019-0130] [PMID: 31169449]
[159]
Xu, L.; Liang, H.W.; Yang, Y.; Yu, S.H. Stability and reactivity: Positive and negative aspects for nanoparticle processing. Chem. Rev., 2018, 118(7), 3209-3250.
[http://dx.doi.org/10.1021/acs.chemrev.7b00208] [PMID: 29517229]

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