Title:Ginger’s Antiapoptotic and Antioxidant Effects on Ovaries of
Cyclophosphamide-therapied Rats
Volume: 29
Issue: 28
Author(s): Maryamsadat Shahidi, Omid Abazari, Parisa Dayati, Bibi Fatemeh Haghiralsadat, Fatemeh Oroojalian*, Javad Zavar Reza*Seyed Morteza Naghib*
Affiliation:
- Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences,
Bojnūrd, Iran
- Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services,
Yazd, Iran
- Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology,
Tehran, Iran
- Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, Motamed Cancer Institute, IUST,
ACECR, Tehran, Iran
Keywords:
Ginger, cyclophosphamide, ovary, oxidative stress, inflammation, apoptosis.
Abstract:
Background: In the recent decade, there has been increasing interest in preventing ovarian toxicity
after chemotherapy exposure. It has been documented that ginger (Zingiber officinale) might normalize the hormonal
balance and control the menstrual cycle..
Objective: This study has analyzed whether ginger extract protects against cyclophosphamide (CP)-induced
ovarian failure in rats.
Methods: Rats were distributed into four groups consisting of vehicle, CP, ginger, and CP + ginger. At the end
of the treatment, all rats were killed under anesthesia to obtain ovarian tissues and blood samples for histological,
molecular, and biochemical experiments.
Results: Our results indicated that ginger improves CP-caused histological changes in ovarian tissues and significantly
restores serum hormonal abnormalities. Ginger also showed unique antioxidant, anti-inflammatory,
and antiapoptotic properties in the ovarian tissues of CP-induced rats. Further, our findings indicated that ginger
might activate the Nrf2 and SIRT and inhibit the PI3K/AKT pathway in the ovaries of CP-treated rats. In
conclusion, ginger was found to protect against CP-caused ovarian toxicity in rats.
Conclusion: The protective impacts of ginger may mediate, at least partly, by alleviating the oxidant state, inhibiting
pro-inflammatory conditions, and exhibiting antiapoptotic activities.
