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ISSN (Print): 2468-1873
ISSN (Online): 2468-1881

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Review Article

Recent Trends in Electrospun Antibacterial Nanofibers for Chronic Wound Management

Author(s): Ganesan Padmini Tamilarasi, Govindaraj Sabarees, Krishnan Manikandan*, Siddan Gouthaman, Veerachamy Alagarsamy* and Viswas Raja Solomon*

Volume 13, Issue 3, 2023

Published on: 31 August, 2023

Page: [159 - 187] Pages: 29

DOI: 10.2174/2468187313666230817151543

TIMBC 2025
Abstract

Chronic wounds and lesions have a severe impact on the socioeconomic status and compliance of patients all over the world. Diabetes-related chronic, non-healing lesions may necessitate amputation of the damaged limb or organ. These skin lesions are susceptible to microorganisms that cause infections that impede the healing process. Despite the advances in medication development and sophisticated formulations, treating persistent wound infections remains difficult. Electrospun antimicrobial wound dressings offer considerable potential for lowering the risk of infection and accelerating the healing of chronic wounds. Electrospinning is a cost-effective, reproducible, simple, and multifaceted technique for encapsulating hydrophobic and hydrophilic therapeutic molecules within polymeric carriers with wide-ranging applications. In this review, we have discussed extensively the recent advances in electrospun nanofiber formulation techniques for use as wound dressings, as well as the entrapment of various antibacterial biomolecules, such as synthetic antibiotics, phytoconstituents, and metal nanoparticles, which have been embedded into the electrospun nanofibers, highlighting bioactive antibacterial agents capable of enhancing wound healing. In addition, we focus on the challenges currently being faced in the area of biomedicine as well as the opportunities for electrospinning-based nanomaterials.

Keywords: Electrospinning, nanofibers, drug delivery, antibacterial agents, metal nanoparticles, phytoconstituents, wound healing.

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Graphical Abstract

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